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 Title: |
US6043345:
IgE isoforms and methods of use
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Saxon, Andrew; Santa Monica, CA
Zhang, Ke; Los Angeles, CA
Max, Edward E.; Bethesda, MD
Lyczak, Jeffrey B.; Los Angeles, CA
Morrison, Sherie L.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-03-28
/ 1996-02-14
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| Application Number: |
US1996000601184
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| IPC Code: |
Advanced:
C07K 16/00;
A61K 38/00;
Core:
more...
IPC-7:
C07K 16/00;
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| ECLA Code: |
C07K16/00;
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| U.S. Class: |
Current:
530/387.1;
530/324;
536/023.53;
Original:
530/387.1;
530/324;
536/023.53;
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| Field of Search: |
530/324,386
536/23.53
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| Government Interest: |
The research described in the subject application was supported at least in part by grants Al15251, A15352 (CIRID at UCLA), CA30515, CA43503 and CA16858 from the National Institutes of Health. The U.S. government may have rights in any patent issuing on this application.
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| Priority Number: |
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| Abstract: |
Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for epsilon transcription products, and compounds that specifically bind epitopes of epsilon translation products. Novel products of the epsilon locus include the following transcription products and translation products thereof: CH4-M2", CH4'-CH5-M1'-M2, CH4'-CH5-M2', CH4'-CH5-M2.increment. and CH4-M2'. Such epsilon products, specific probes and binding compounds find use in methods and kits for immune hypersensitivity diagnosis and treatment.
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| Attorney, Agent or Firm: |
Trecartin, Richard F. ;
Kresnak, Mark T.Flehr Hohbach Test Albritton and Herbert LLP ;
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| Primary / Asst. Examiners: |
Feisee, Lila; Davis, Minh-Tam
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| Maintenance Status: |
E1 Expired Check current status
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 122(09)103932X
CHEMABS 132(19)250009M
CHEMABS 132(19)250009M
DERABS C2000-270352
DERABS C1994-316938
DERABS C2000-270352
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| Other References: |
Peng, C. 1992. J. Immunology, 148:129-136.
(8 pages)
Cited by 5 patents
[ISI abstract]
Hellman L. 1993. Eur. J. Immunology 23:159-167.
(9 pages)
Cited by 3 patents
[ISI abstract]
Batista et al., "Characterization and Expression of Alternatively Spliced IgE Heavy Chain Transcripts Produced by Peripheral Blood Lymphocytes," J. of Immunology (1995), 209-218.
(10 pages)
Cited by 2 patents
[ISI abstract]
Zhang et al., "Complex Alternative RNA Splicing of ε-Immunoglobulin Transcripts Produces mRNAs Encoding Four Potential Secreted Protein Isoforms," J. of Biological Chemistry (Jan. 1994), 269:456-462.
(7 pages)
Cited by 2 patents
[ISI abstract]
Efremov et al., "Molecular Analysis of IgE H-Chain Transcripts Expressed in Vivo by Peripheral Blood Lymphocytes from Normal and Atopic Individuals," J. of Immunology (Aug. 1993), 151:2195-2207.
(13 pages)
Cited by 2 patents
[ISI abstract]
Peng et al., "A New Isoform of Human Membrane-Bound IgE," J. of Immunology (Jan. 1992), 148:129-136.
(8 pages)
Cited by 5 patents
[ISI abstract]
Seno et al., "Molecular Cloning and Nucleotide Sequencing of Human Immunoglobulin ε Chain cDNA," Nucleic Acids Research (1983), 11:719-726.
(8 pages)
Cited by 16 patents
Flanagan and Rabbits, "The Sequence of a Human Immunoglobulin Episilon Heavy Chain Constant Region Gene, and Evidence for Three Non-Allelic Genes," The EMBO Journal (1982), 1:655-660.
(6 pages)
Cited by 2 patents
Max et al., "Duplication and Deletion in the Human Immunoglobulin ε Genes," Cell (Jun. 1982), 29:691-699.
(9 pages)
Cited by 3 patents
Diaz-Sanchez, D., et al. "Differential Regulation of Alternative 3' Splicing of ε Messenger RNA Variants" J. of Immunology (1995), 155:1930-1941.
(12 pages)
[ISI abstract]
Lyczak, J., et al. "Expression of Novel Secreted Isoforms of Human Immunoglobulin E Proteins" J. Biological Chemistry (Feb. 1996), 271:3428-3436.
(9 pages)
Cited by 2 patents
[ISI abstract]
Diaz-Sanchez, D., et al. "Diesel Exhaust Particles Induce Local IgE Production In Vivo and Alter the Pattern of IgE Messenger RNA Isoforms" J. of Clinical Investigation (Oct. 1994) 94:1417-1425.
(9 pages)
Cited by 2 patents
[ISI abstract]
Zhang, K., et al. "Germ-Line Human Epsilon Heavy Chain Gene RNA Transcripts Utilize The Full Range of Alternative 3' Splicing Seen in Productive ε mRNA" Immunology (1995), 85:228-235.
(8 pages)
[ISI abstract]
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