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 Title: |
US6051218:
Tumor radiosensitization using gene therapy
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
McBride, William H.; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-04-18
/ 1996-02-02
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| Application Number: |
US1996000597524
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| IPC Code: |
Advanced:
A61K 31/00;
A61K 38/00;
A61K 38/19;
A61K 38/20;
A61K 39/00;
A61K 51/00;
A61P 35/00;
C12N 5/10;
C12N 15/09;
A61K 48/00;
Core:
more...
IPC-7:
A61K 48/00;
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| ECLA Code: |
A61K38/19B; A61K39/00D6; A61K39/00D6+M; A61K38/20;
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| U.S. Class: |
Current:
424/093.21;
435/375;
514/044.R;
Original:
424/093.21;
514/044;
435/375;
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| Field of Search: |
435/320.1,240.2,6,172.3,7.2,375
935/062,52,55-57,34,70,71,33,65
424/93.1,93.21,184.1,9.4
514/044
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| Priority Number: |
| 1996-02-02 |
US1996000597524 |
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| Abstract: |
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method of radiosensitizing a tumor in a subject by administering, at a site other than the tumor, a cell genetically modified to express a cytokine. The invention further provides a method of reducing the severity of a cancer in a subject by administering a cytokine at the site of the tumor or by immunizing the subject at a site other than the tumor with tumor cells genetically modified to express a cytokine, and treating the tumor with radiotherapy.
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| Attorney, Agent or Firm: |
Campbell & Flores LLP ;
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| Primary / Asst. Examiners: |
Hauda, Karen M.;
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| Maintenance Status: |
E1 Expired Check current status
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE CA EP JP
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| Family: |
Show 9 known family members
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First Claim:
Show all 2 claims |
I claim:
1. A method of inhibiting the growth of a tumor in a mammal, comprising
- (a) administering a tumor cell expressing interleukin-3 to said mammal, wherein expression of interleukin-3 stimulates an immune response against the tumor and wherein said tumor has increased radiation susceptibility, wherein said tumor cell has at least one antigen in common with said tumor; and
- (b) treating said tumor with radiation, wherein the growth of said tumor is inhibited.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 127(11)146537T
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| Other References: |
Malcolm S. Mitchell, Combining Chemotherapy and Biomodulation in the Treatment of Cancer, in Human Tumor Antigens and Specific Tumor Therapy, UCLA Symposium at Keystone Colorado 99:345-358 (Metzgar and Mitchell ed., 1989).
Vieweg et al. "Immunotherapy of Prostate Cancer in the Dunning Rat Model: Use of Cytokine Gene Modofied Tumor Vaccines," Cancer Research, vol. 54: 1760-1765., Apr. 1,1994.
(6 pages)
Cited by 13 patents
[ISI abstract]
Vieweg et al. "Considerations for the use of Cytokine-Secreting Tumor Cell Preparations for Cancer Treatment," Cancer Investigation, vol. 13: 193-201, 1995.
(9 pages)
Cited by 36 patents
[ISI abstract]
Colombo, et al., "Granulocyte Colony-stimulating a Factor Gene Transfer Suppresses Tumorigenicity of a Murine Adenocarcinoma In Vivo." J. Exp. Med. 173:889-897 (1991).
(9 pages)
Cited by 14 patents
[ISI abstract]
Golumbek et al., "Controlled Release, Biodegradable Cytokine Depots: A New Approach in Cancer Vaccine Design." Cancer Research 53:5841-5844 (1993).
(4 pages)
Cited by 18 patents
[ISI abstract]
Lange et al., "A Pilot Study of the Combination of Interleukin-2-Based Immunotherapy and Radiation Therapy." Journal of Immunotherapy 12:265-271 (1992).
(7 pages)
Cited by 6 patents
[ISI abstract]
Matsumoto et al., "Recombinant Human Granulocyte Colony-Stimulating Factor Inhibits the Metastasis of Hematogenous and Non-Hematogenous Tumors in Mice." Int. J. Cancer 49:444-449 (1991).
(6 pages)
Cited by 6 patents
[ISI abstract]
McBride et al., "Modification of Tumor Microenvironment by Cytokine Gene Transfer." Acta Oncologica 34:447-451 (1995).
(5 pages)
Cited by 6 patents
[ISI abstract]
McBride and Dougherty, "Radiotherapy for genes that cause cancer." Nature Medicine 1:1215-1217 (1995).
(3 pages)
Cited by 6 patents
[ISI abstract]
McDonald et al., "Combined Betaseron R (Recombinant Human Interferon Beta) and Radiation for Inoperable Non-Small Cell Lung Cancer." Int. J. Radiation Oncology Biol. Phys. 27:613-619 (1993).
(7 pages)
Cited by 8 patents
[ISI abstract]
Sersa et al., "Anti-Tumor Effects of Tumor Necrosis Factor Alone or Combined with Radiotherapy." Int. J. Cancer 42:129-134 (1988).
(6 pages)
Cited by 10 patents
Younes et al., "Radiation-Induced Effects on Murine Kidney Tumor Cells: Role in the Interaction of Local Irradiation and Immunotherapy." The Journal of Urology 153:2029-2033 (1995).
(5 pages)
Cited by 5 patents
[ISI abstract]
Coghlan, A. "Gene dream fades away," New Scientist, vol. 145: 14-15, Nov. 25, 1995.
(2 pages)
Cited by 111 patents
[ISI abstract]
Brown, D. "Gene Therapy `Oversold` by Researchers, Journalists," The Washington Post, A22, Dec. 8, 1995.
Gansbacher, et al. "Retroviral Vector-Mediated Cytokine-Gene Transfer into Tumor Cells," Cancer Investigation, vol. 11(3):345-354, Mar. 1993.
(10 pages)
Cited by 10 patents
[ISI abstract]
McBride et al. "Interleukin-3 in Gene Therapy of Cancer," Filia Biologica, vol. 40: 62-73, Feb. 1994.
(12 pages)
Cited by 6 patents
[ISI abstract]
Zhang et al. "Gene Therapy strategies for cancer," Expert Opinion on Investigational Drugs, vol. 4(6): 487-514, Jun. 1995.
Weichselbaum et al. "Gene Therapy Targeted by Radiation Preferentially Radiosensitizes Tumor Cells," Cancer Research, vol. 54: 4266-4269, Aug. 15, 1994.
(4 pages)
Cited by 12 patents
[ISI abstract]
Dranoff, et al. "Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity," Proc. Natl. Acad. Sci., vol. 90:3539-3543, Apr. 1993.
(5 pages)
Cited by 45 patents
[ISI abstract]
Patchen et al. "Mast cell growth factor (C-kit ligand) in combination with granulocyte macrophage colony-stimulating factor and interleukin-3: in vivo hemopoietic effects in irradiated mic compared to in vitro effects," Biotherapy, vol. 7(1): 13-26, Jan. 1994.
Tepper et al. "Experimental and Clinical Studies of Cytokine Gene-Modified Tumor Cells," Human Gene Therapy, vol. 5: 153-164, 1994.
(12 pages)
Cited by 13 patents
[ISI abstract]
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US1996000597524 | 1996-02-02 | is a
related to the prior publication |
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US20030185810A1 issued 2003-10-02 Tumor radiosensitization using gene therapy
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US2003000420278 | 2003-04-21 | is a
continuation of |
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US2000000535654
| 2000-03-24 |
(granted)
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US6551588 issued 2003-04-22 Tumor radiosensitization using gene therapy
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US2003000420278 | | is a
continuation of |
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US2000000535654
| 2000-03-24 |
|
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US6551588 issued 2003-04-22 Tumor radiosensitization using gene therapy
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US2000000535654 | 2000-03-24 | is a
continuation of |
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>US1996000597524<
| 1996-02-02 |
(granted)
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US6051218 issued 2000-04-18 Tumor radiosensitization using gene therapy
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US2000000535654 | | is a
continuation of |
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>US1996000597524<
| 1996-02-02 |
|
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US6051218 issued 2000-04-18 Tumor radiosensitization using gene therapy
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