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Title: US6054133: Anti-microbial targeting for intracellular pathogens
[ Derwent Title ]


Country: US United States of America

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11 pages

 
Inventor: Horwitz, Marcus A.; Los Angeles, CA
Clemens, Daniel L.; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-04-25 / 1997-07-10

Application Number: US1997000890858

IPC Code: Advanced: A61K 47/48; A61P 31/04;
Core: A61P 31/00; more...
IPC-7: A61K 39/08; A61K 39/38; A61K 39/395; A61K 45/00;

ECLA Code: A61K47/48R; A61K47/48R2P; A61K47/48W6H;

U.S. Class: Current: 424/248.1; 424/184.1; 424/278.1; 424/450; 424/812; 514/002; 514/037; 514/078;
Original: 424/248.1; 424/278.1; 424/184.1; 424/450; 424/812; 514/002; 514/037; 514/078;

Field of Search: 424/248.1,184.1,450,278.1,812 514/078,2,37

Government Interest:     This invention was made with Government support under Grant No. AI-35275 awarded by the National Institute of Health (NIH). The Government has certain rights in this invention.

Priority Number:
1997-07-10  US1997000890858

Abstract: A method and composition are provided for treating intracellular pathogens that reside in phagosomes. The compositions include antibiotics which are conjugated with transferrin or other ligands to form conjugates that target membrane-bound pathogens. The conjugates are selectively taken up by infected phagosomes. Conjugates are provided which utilize transferrin as the targeting ligand for treating mycobacterium which reside in membrane-bound phagosomes.

Attorney, Agent or Firm: Oppenheimer Wolff & Donnelly LLP ;

Primary / Asst. Examiners: Minnifield, Nita;

INPADOC Legal Status: Show legal status actions

Family: None

First Claim:
Show all 15 claims
What is claimed is:     1. A composition for use in delivering an antiboitic to a phagosome which contains a pathogen, said composition comprising an antibiotic coupled to a ligand selected from the group consisting of transferrin and low density lipoprotein.

Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 3 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (3)   |   Backward references (21)   |   Citation Link

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Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 15pp US4193983  1980-03 Ullman et al.  Syva Company Labeled liposome particle compositions and immunoassays therewith
Buy PDF- 16pp US4208479  1980-06 Zuk et al.  Syva Company Label modified immunoassays
Buy PDF- 12pp US4575484  1986-03 Straus  Montefiore Medical Center, Inc. Binding assay for the detection of mycobacteria
Buy PDF- 8pp US5158979  1992-10 Clarkson et al.  New York University Method and compositions for treating pneumocystic carini infections
Buy PDF- 9pp US5302598  1994-04 Clarkson et al.  New York University Method and compositions for treating Pneumocystic carinii infections
Buy PDF- 8pp US5428023  1995-06 Russell-Jones et al.  Biotechnology Australia Pty. Ltd. Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof
Buy PDF- 8pp US5462969  1995-10 Clarkson et al.  New York University Method and compositions for treatment or prevention of pneumocystic carinii infections
Buy PDF- 50pp US5510264  1996-04 Van Alstyne et al.  Insight Biotech Inc. Antibodies which bind meningitis related homologous antigenic sequences
Buy PDF- 29pp US5543390  1996-08 Yatvin et al.  State of Oregon, Acting by and Through the Oregon State Board of Higher Education, Acting for and on Behalf of the Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
Buy PDF- 27pp US5543391  1996-08 Yatvin et al.  State of Oregon, Acting by and Through the Oregon State Board of Higher Education, Acting for and on Behalf of the Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
Buy PDF- 22pp US5612182  1997-03 Pearson et al.  Becton, Dickinson and Company Mycobacteriophage specific for the mycobacterium tuberculosis complex
Buy PDF- 28pp US5633234  1997-05 August et al.  The Johns Hopkins University Lysosomal targeting of immunogens
Buy PDF- 15pp US5643599  1997-07 Lee et al.  President and Fellows of Harvard College Intracellular delivery of macromolecules
Buy PDF- 8pp US5662929  1997-09 Lagace et al.  Universite de Montreal Therapeutic liposomal formulation
Buy PDF- 59pp US5679347  1997-10 Porcelli et al.  Brigham and Women's Hospital Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods
Buy PDF- 54pp US5712095  1998-01 Britschgi et al.  Becton Dickinson and Company Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probes specific for ribosomal RNA precursors
Buy PDF- 15pp US5721209  1998-02 Horwitz et al.  The Regents of the University of California Iron chelator and inhibitor of iron-mediated oxidant injury
Buy PDF- 45pp US5726021  1998-03 Britschgi et al.  Becton Dickinson and Company Rapid and sensitive detection of antibiotic-resistant mycobacteria using oligonucleotide probes specific for ribosomal RNA precursors
Buy PDF- 91pp US5728680  1998-03 Morozov et al.  Cytoven J.V. Methods for normalizing numbers of lymphocytes
Buy PDF- 13pp US5830478  1998-11 Raso et al.  Boston Biomedical Research Institute Method for delivering functional domains of diphtheria toxin to a cellular target
Buy PDF- 32pp US5837283  1998-11 McDonald et al.  The Regents of the University of California Cationic lipid compositions targeting angiogenic endothelial cells
       
Foreign References:
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PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 52pp WO9001945 1990-03  A61K 39/02 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA BACTERIAL VACCINE AGAINST LEGIONELLA PNEUMOPHILA AND OTHER VIRULENT PATHOGENS 
Buy PDF- 54pp WO9712057 1997-04  A61K 31/00 CLEMENS DANIEL L CHEMOTHERAPEUTIC AGENTS FOR MYCOBACTERIUM 


Other Abstract Info: DERABS C2000-338484 DERABS C2000-338484

Other References:
  • Horwitz et al, PNAS, 92:1530-1534, 1995.
  • Horwitz et al, J. Clin. Invest. 71:15-26, 1983. (12 pages)
  • Schlesinger et al, Infect & Imm. 62/1:280-289, 1994. (10 pages) [ISI abstract]
  • Horwitz, Immunol. Ser. 42(Interferon Nonviral Pathog):287-294, 1988.
  • Gobin et al J. Exp. Med. 183:1527-1532, Apr. 1996. (6 pages) Cited by 4 patents [ISI abstract]
  • Clemens et al, J. Exp. Med. 184:1349-1355, Oct. 1996. (7 pages) [ISI abstract]
  • Bhardwaj et al, J. Interferon Res. 8:283-293, 1988. (11 pages)
  • Armstrong, J.A., D'Arcy Hart, P., "Response of Cultured Macrophages to Mycobacerium Tuberculosis, with Observations on Fusion of Lysosomes with Phagosomes," J. Exper. Med., vol. 134, No. 3, pt. 1, (1971), pp. 713-740.
  • Crowle, A.J., Dahl, R., Ross, E. and May, M.H., "Evidence that Vesicles Containing Living, Virulent Mycobacterium tuberculosis of Mycobacterium avium in Cultured Human Macrophages are not Acidic," Infection and Immunity, vol. 59, No. 5 (1991), pp. 1823-1831. (9 pages) [ISI abstract]
  • Songmei, X., Cooper, A., Sturgill-Koszycki, S., van Heyningen, T., Chatterjee, D., Orme, I., Allen, P. and Russell, D.G., "Intracellular Trafficking in Mycobacterium tuberculosis and Mycobacterium avium-Infected Macrophages," J. Immunol., (1994), pp. 2568-2578. (11 pages) [ISI abstract]
  • Clemens, D.L. and Horwitz, M.A., "Characterization of the Mycobacterium tuberculosis Phagosome and Evidence that Phagosomal Maturation is Inhibited," J. Exp. Med., vol. 181 (1995) pp. 257-270. (14 pages) Cited by 4 patents [ISI abstract]
  • Horwitz, M.A., "The Legionnaires' Disease Bacterium (Legionella Pneumophila) Inhibits Phagosome-Lysosome Fusion in Human Monocytes," J. Exp. Med., vol. 158 (1983) pp. 2108-2126. (19 pages) Cited by 10 patents
  • Horwitz, M.A. and Maxfield, F.R., "Legionella pneumophila Inhibits Acidification of its Phagosome in Human Monocytes," J. Cell Biol., vol. 99, (1984), pp. 1936-1943. (8 pages) Cited by 10 patents
  • Clemens, D.L. and Horwitz, M.A., "Membrane Sorting during Phagocytosis: Selective Exclusion of Major Histocompatibility Complex Molecules but not Complement Receptor CR3 during Conventional and Coiling Phagocytosis," J. Exp. Med., vol. 175 (1992), pp. 1317-1326. (10 pages) [ISI abstract]
  • Clemens, D.L. and Horwitz, M.A., "Hypoexpression of Major Histocompatibility Complex Molecules on Legionella pneumophila Phagosomes and Phagolysosomes," Infection and Immunity, vol. 61, No. 7 (1993), pp. 2803-2812. (10 pages) [ISI abstract]
  • Dautry-Varsat, A., Ciechanover, A. and Lodish, H.F., "pH and the recycling of transferrin during receptor-mediated endocytosis," Proc. Natl. Acad. Sci. USA, vol. 80 (1983), pp. 2258-2262. (5 pages) Cited by 9 patents
  • Frens, G., "Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions," Nature Phys. Sci., vol. 241 (1973), pp. 20-22. (3 pages) Cited by 32 patents
  • Allison, A.C. and Byars, N.E., "An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity," J. Immunol. Meth., 95 (1986), pp. 157-168. (12 pages) Cited by 19 patents
  • Rabinowitz, S., Horstmann, H., Gordon, S. and Griffiths, G., "Immunocytochemical Characterization of the Endocytic and Phagolysosomal Compartments in Peritoneal Macrophages," J. Cell. Biol, vol. 116, No. 1 (1992), pp. 95-112. (18 pages) [ISI abstract]
  • Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J. and Russell, D.G., "Lack of Acidification in Mycobacterium Phagosomes Produced by Exclusion of the Vesicular Proton-ATPase," Science, vol. 263 (1994), pp. 678-681. (4 pages) Cited by 15 patents [ISI abstract]
  • Harth, G., Lee, B-Y, Wang, J., Clemens, D.L., Horwitz, M.A., "Novel Insights into the Genetics, Biochemistry, and Immunocytochemistry of the 30-Kilodalton Major Extracellular Protein of Mycobacterium tuberculosis," Infection and Immunity, vol. 64, No. 8 (1996), pp. 3038-3047. (10 pages) Cited by 3 patents [ISI abstract]
  • van Renswoude, J., Bridges, K.R., Harford, J.B. and Klausner, R.D., "Receptor-mediated endocytosis of transferrin and the uptake of Fe in K562 cells: Identification of a nonlysosomal acidic compartment," Proc. Natl. Acad. Sci. USA, vol. 79 (1982), pp. 6180-6190.


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