 |
|
|
|
|
|
 Title: |
US6074835:
Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Braun, Johnathan; Tarzana, CA
Targan, Stephan R.; Santa Monica, CA
Eggena, Mark; Los Angeles, CA
|
| Assignee: |
Regents of the Univ. of California, Oakland, CA
Cedars-Sinai Medical Center, Los Angeles, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
2000-06-13
/ 1997-04-11
|
| Application Number: |
US1997000837058
|
| IPC Code: |
Advanced:
G01N 33/68;
Core:
more...
IPC-7:
G01N 33/564;
|
| ECLA Code: |
G01N33/68H; S01N800/06B;
|
| U.S. Class: |
Current:
435/007.21;
435/007.24;
435/007.95;
436/506;
436/508;
Original:
435/007.211;
435/007.24;
435/007.95;
436/506;
436/508;
|
| Field of Search: |
435/7.21,7.24,7.85
436/506,508
|
| Government Interest: |
ACKNOWLEDGMENT
This work was supported by grant number DK46763 awarded by the National Institutes of Health and by grant number GM08042 awarded by the National Institutes of Health. The United States government has certain rights in this invention.
|
| Priority Number: |
| 1997-04-11 |
US1997000837058 |
| 1996-04-12 |
US1996000057846P |
|
| Abstract: |
The present invention provides a method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease by by obtaining a sample from the individual; contacting the sample with human histone H1, or pANCA-reactive fragment thereof, under conditions suitable to form a complex of human histone H1, or pANCA-reactive fragment thereof, and antibody to human histone H1; and detecting the presence or absence of the complex, where the presence of the complex indicates that the individual has UC. The invention also provides related methods of diagnosing a perinuclear anti-neutrophil cytoplasmic antibody positive (pANCA-positive) clinical subtype of UC in a patient with UC. In addition, the invention further provides methods of determining susceptibility to UC in an individual. The invention further provides methods of inducing tolerance in a pANCA-positive patient with UC by administering an effective dose of histone H1, or tolerogenic fragment thereof, to the pANCA-positive patient with UC. Compositions of histone H1, or fragment thereof, combined with a tolerogizing molecule also are provided.
|
| Attorney, Agent or Firm: |
Campbell & Flores LLP ;
|
| Primary / Asst. Examiners: |
Saunders, David;
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
| Parent Case: |
RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Application No. 60/057,846, filed Apr. 12, 1996, which was converted from application Ser. No. 08/630,671 and which is incorporated herein by reference.
|
| Family: |
Show 11 known family members
|
First Claim:
Show all 21 claims |
We claim:
1. A method of diagnosing ulcerative colitis (UC) in a subject suspected of having inflammatory bowel disease, comprising:
- (a) obtaining a sample from said subject;
- (b) contacting said sample with a substantially purified histone H1 polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 6, or a modification or fragment thereof having immunological reactivity with pANCA, under conditions suitable to form a complex of said histone H1, or modification or fragment thereof, with antibody to histone H1; and
- (c) detecting the presence or absence of said complex, wherein the presence of said complex indicates that said subject has UC.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
| Forward References: |
Show 3 U.S. patent(s) that reference this one
|
|
|
|
|
|
|
| Foreign References: |
None
|
| Other Abstract Info: |
CHEMABS 132(16)206929N
DERABS C2000-255695
|
| Other References: |
Pool et al, GUT, 34, 46-50, 1993.
(5 pages)
Cited by 8 patents
[ISI abstract]
Proudjansky et al, J. Pediat. Gastruent. Nutr. 17, 193-197, 1993.
Reumaux et al, Clin. Immunol. Immunopath., 77, 349-357, 1995.
(9 pages)
Cited by 2 patents
[ISI abstract]
Saxon et al, J. Allerg. Clin. Immunol., 86, 202-210, 1990.
(9 pages)
Cited by 17 patents
Sobajima et al, Clin. Exp. Immunol., 107, 135-140, 1997.
(6 pages)
Cited by 12 patents
[ISI abstract]
Bradbury, "Reversible Histone Modifications and the Chromosome Cell Cycle," BioEssays 14:9-16 (1992).
(8 pages)
[ISI abstract]
Doenecke et al., "Organization and Expression of H1 Histone and H1 Replacement Histone Genes," J. Cell. Biochem. 54:423-431 (1994).
(9 pages)
[ISI abstract]
Lu et al., "Generation and Characterization of Novel Antibodies Highly Selective for Phosphorylated Linker Histone H1 in Tetrahymena and HeLa Cells," Chromosoma 103:111-121 (1994).
(11 pages)
Cited by 2 patents
[ISI abstract]
Muller et al., "Immunogenicity of Free Histones and of Histones Complexed with RNA," Molec. Immunol. 28:763-772 (1991).
(10 pages)
Cited by 2 patents
[ISI abstract]
Parseghian et al., "Characterization of a Set of Antibodies Specific for Three Human Histone H1 Subtypes," Chromosomam 103:198-208 (1994).
(11 pages)
[ISI abstract]
Parseghian et al., "A Proposal for a Coherent Mammalian Histone H1 Nomenclature Correlated with Amino Acid Sequences," Protein Sci. 3:575-587 (1994).
(13 pages)
Cited by 2 patents
[ISI abstract]
Rubin and Farber (eds.), "Inflammatory Bowel Disease," Pathology (2nd Ed.), pp. 675-683 (1994).
Saxon et al., "A Distinct Subset of Antineutrophil Cytoplasmic Antibodies is Associated with Inflammatory Bowel Disease," J. Allergy Clin. Imunol. 86:202-210 (1990).
(9 pages)
Cited by 17 patents
Steinman, "Escape from `Horror Autotoxicus`: Pathogenesis and Treatment of Autoimmune Disease," Cell 80:7-1 (1995).
(4 pages)
Cited by 20 patents
[ISI abstract]
Tan, "Autoantibodies in Pathology and Cell Biology," Cell 67:841-842 (1991).
(2 pages)
Cited by 5 patents
[ISI abstract]
Weiner et al., "Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens," Ann. Rev. Immunol. 12:809-837 (1994).
(29 pages)
Cited by 48 patents
[ISI abstract]
Weiner, "Oral Tolerance: Mobilizing the Gut," Hosp. Prac. 53-58 (Sep. 15, 1995).
(6 pages)
Cited by 3 patents
[ISI abstract]
|
| Continuity Data: |
| Application Number | Filed | Notes |
|---|
|
|
US1997000837058 | 1997-04-11 | is a
related to the prior publication |
| |
US20030092080A1 issued 2003-05-15 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
|
|
|
|
US2002000229567 | 2002-08-27 | is a
continuation of |
|
US1999000417264
| 1999-10-12 |
(pending)
[presumed granted]
|
| |
US6537768 issued 2003-03-25 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens
|
|
|
|
US2002000229567 | | is a
continuation of |
|
US1999000417264
| 1999-10-12 |
|
| |
US6537768 issued 2003-03-25 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC panca antigens
|
|
|
|
US1999000417264 | 1999-10-12 | is a
continuation of |
|
US1998000041889
| 1998-03-12 |
(granted)
|
| |
US6033864 issued 2000-03-07 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
|
|
|
|
US1999000417264 | | is a
continuation of |
|
US1998000041889
| 1998-03-12 |
|
| |
US6033864 issued 2000-03-07 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using microbial UC pANCA antigens
|
|
|
|
US1998000041889 | 1998-03-12 | is a
continuation in part of |
|
>US1997000837058<
| 1997-04-11 |
(granted)
|
| |
US6074835 issued 2000-06-13 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
|
|
|
|
US1998000041889 | | is a
continuation in part of |
|
>US1997000837058<
| 1997-04-11 |
|
| |
US6074835 issued 2000-06-13 Diagnosis, prevention and treatment of ulcerative colitis, and clinical subtypes thereof, using histone H1
|
|
|
|
US1997000837058 | 1997-04-11 | is a
non-provisional of provisional |
|
US1996000057846P
| 1996-04-12 |
|
|
|
 Nominate this for the Gallery...
|
|
