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Title: US6093800: E25a protein, methods for production and use thereof
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Country: US United States of America

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32 pages

 
Inventor: Reiter, Robert E.; Los Angeles, CA
Witte, Owen N.; Sherman Oaks, CA
Sawyers, Charles L.; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-07-25 / 1997-09-05

Application Number: US1997000924570
IPC Code: Advanced: C07K 14/705;
Core: C07K 14/435;
IPC-7: C07K 5/00;

ECLA Code: C07K14/705;

U.S. Class: Current: 530/350;
Original: 530/350;

Field of Search: 530/350,395

Priority Number:
1997-09-05  US1997000924570
1996-09-06  US1996000025569P

Abstract: The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

Attorney, Agent or Firm: Mandel & Adriano ;

Primary / Asst. Examiners: Huff, Sheela;

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Parent Case:     This application is based on a provisional application, U.S. Ser. No. 06/025,569, filed Sep. 6, 1996, the contents of which are hereby incorporated by reference into this application.

Designated Country: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE  AU CA EP JP MX 

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Claim What is claimed is:     1. An isolated protein designated E25a having the amino acid sequence shown in FIG. 1 (SEQ ID NO.2).

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Forward References: Show 8 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (8)   |   Backward references (0)   |   Citation Link

       
Foreign References:
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PDF		 Publication Date IPC Code Assignee   Title
Buy PDF- 192pp WO9409820 1994-05  A01K 67/027 FAIR WILLIAM R PROSTATE-SPECIFIC MEMBRANE ANTIGEN 


Other Abstract Info: CHEMABS 128(20)242881S DERABS C1998-193619

Other References:
  • Hillier, L., et al., "The WashU-Merck EST project, AC W37917," EMBL Database, Heidelberg, XP002058366. May 17, 1996.
  • Hillier, L., et al., "The WashU-Merck EST project AC N32815," EMBL Database, Heidelberg, XP002058367. Jan 13, 1996.
  • Deleersnijder, W., et al., "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction," The Journal of Biochemical Chemistry, 271(32):19475-19482, XP002058368. Aug. 9, 1996.
  • Reiter, R., et al., "Representational difference analysis of human androgen independent prostate cancer," Proceedings of the American Association for Cancer Research, 37:246-247, XP002058557. Mar. 1996.
  • Raffo, A., et al., "Overexpression of bcl-2 protects prostate cancer cells form apoptosis in vitro and confers resistance to androgen depletion in vivo," Cancer Research, 55(19):4438-4445. XP002058467. Oct. 1, 1995.
  • Rinker-Schaeffer, C., et al., "Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells," The Prostate, 25(5):249-265, XP002058468. 1994.
  • Reiter, R., et al., "Two genes upregulated in androgen-independent prostate cancer are also selectively expressed in the basal cells of normal prostate epithelium," Journal of Urology, Supplement, 157(4):269, XP002058558. Apr. 4, 1997.


    • Continuity Data:
    Application Number Filed Notes
    US1999000451214   is a division of
    >US1997000924570<  1997-09-05
         US6093800 issued 2000-07-25   E25a protein, methods for production and use thereof
    US1997000924570 1997-09-05  is a non-provisional of provisional
    US1996000025569P  1996-09-06


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