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Title: US6106844: Immunomodulatory peptides of vespid antigen 5
[ Derwent Title ]


Country: US United States of America

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60 pages

 
Inventor: King, Te Piao; New York, NY

Assignee: The Rockfeller University, New York, NY
other patents from ROCKEFELLER UNIVERSITY (479685) (approx. 357)
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Published / Filed: 2000-08-22 / 1998-08-06

Application Number: US1998000130287

IPC Code: Advanced: A61K 31/00; A61K 38/00; A61K 39/35; A61P 37/00; A61P 37/08; C07K 7/08; C07K 14/435;
Core: C07K 7/00; more...
IPC-7: A61K 39/00; A61K 39/35; A61K 39/36;

ECLA Code: C07K14/435A4B;

U.S. Class: Current: 424/275.1; 424/184.1; 424/185.1; 435/069.1; 530/300; 530/806; 530/858; 536/023.2; 536/023.5;
Original: 424/275.1; 424/184.1; 424/185.6; 435/069.1; 530/300; 530/806; 530/858; 536/023.2; 536/023.5;

Field of Search: 424/275.1,184.1,185.1 435/69.1 530/300,806,858 536/23.2,23.5

Government Interest:     The research leading to the present invention was supported by United States Public Health Service Grant No. AI-17021. The government may have certain rights in the invention.

Priority Number:
1998-08-06  US1998000130287
1996-03-11  US1996000614935

Abstract: The present invention is directed to immunogenic peptides from vespid antigen 5. These immunogenic peptides can be used in immunotherapy for vespid venom allergic individuals. The present invention is thus directed to T cell epitopes of vespid antigen 5 that can anergize T cell responses in sensitive individuals.

Attorney, Agent or Firm: Darby & Darby ;

Primary / Asst. Examiners: Woodward, Michael P.; Zeman, Mary K

INPADOC Legal Status: None          Buy Now: Family Legal Status Report

       
Related Applications:
Application Number Filed Patent Pub. Date  Title
US1996000614935 1996-03-11    1998-09-08  Immunomodulatory peptides of vespid antigen 5


       
Parent Case:     This Application is a Division of application Ser. No. 08/614,935 filed Mar. 11, 1996 now U.S. Pat. No. 5,804,201, issued Sep. 8, 1998.

Designated Country: AL AM AP AZ BA BB BG BR BY CN CU CZ EE GE GH HU IL IS KG KP KR KZ LC  AT BE CH DE DK ES FI FR GB GR IE IT LI 

Family: Show 8 known family members

First Claim:
Show all 11 claims
What is claimed is:     1. A method for treating sensitivity to vespid venom antigen 5 comprising administering to a vespid venom allergic patient a therapeutically effective amount of a peptide characterized by the following properties:
  • a) it has a range of about 8 to about 35 amino acid residues of vespid venom antigen 5; and,
  • b) it is antigenic for T cell proliferation in a mouse immunized with a vespid venom antigen 5, which mouse is a strain selected from the group consisting of BALB/c, ASW/Sn, C3H/He, and P/J.


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Forward References: Show 2 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (2)   |   Backward references (0)   |   Citation Link

       
Foreign References:
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PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 94pp WO9420623 1994-09  C12N 15/09 THE ROCKEFELLER UNIVERSITY CLONING AND RECOMBINANT PRODUCTION OF VESPID VENOM ENZYMES, SUCH AS PHOSPHOLIPASE AND HYALURONIDASE, AND IMMUNOLOGICAL THERAPIES BASED THEREON 


Other Abstract Info: CHEMABS 127(21)292054Z DERABS C1997-470817

Other References:
  • Hoffman, "Hymenoptia Venom Proteins" in National Toxins, R.B. Singh (ed.), Plenum Publishing 6 (1996).
  • King et al., J. Allergy Clin. Immunol.98:588-600 (1996). (13 pages) Cited by 7 patents [ISI abstract]
  • Muller et al., J. Allergy Clin. Immunol. 97:426 (1996).
  • Forster et al. (1995) J. Allergy Clin. Immunol. 95:1229-35. (7 pages) Cited by 4 patents [ISI abstract]
  • King et al., J. Immunol., 154:577 (1995). (8 pages) Cited by 6 patents [ISI abstract]
  • Muller et al., J. Allergy Clin. Immunol. 96:395-402 (1995). (8 pages) Cited by 2 patents [ISI abstract]
  • Norman et al., J. Allergy Clin. Immunol. 95:259 (1995). (1 pages) Cited by 2 patents [ISI abstract]
  • Briner et al., Proc. Natl. Acad. Sci. U.S.A., 90:7608-12 (1993). (5 pages) Cited by 16 patents [ISI abstract]
  • Hoyne et al., J. Exp. Med., 178:1783-1788 (1993). (6 pages) Cited by 6 patents [ISI abstract]
  • T.P. King, in "Bronchial Asthma," edited by E.B. Weiss and M. Stein, Little Brown, Boston, pp. 43-49 (1993).
  • King et al., J. Allergy Clin. Immunol., 91:283 (1993). (1 pages) Cited by 4 patents [ISI abstract]
  • Lu et al., J. Immunol. 150:2823 (1993). (8 pages) Cited by 10 patents [ISI abstract]
  • P.S. Norman, Current Op. Immunol., 5:968 (1993). (6 pages) Cited by 3 patents [ISI abstract]
  • O'Hehir et al., Eruop. J. Clin. Invest., 23:763 (1993). (10 pages) Cited by 2 patents [ISI abstract]
  • Mizuku et al., Mammalian Genome, 3:274-280 (1992).
  • Ales-Martinez, et al., Immunol. Today, 12:201 (1991). (5 pages) Cited by 6 patents [ISI abstract]
  • O'Hehir et al., Ann. Rev. Immunol., 9:67 (1991). (29 pages) Cited by 11 patents [ISI abstract]
  • Fang et al., Proc. Natl. Acad. Sci., USA, 85:895-899 (1988). (5 pages) Cited by 13 patents
  • King, J. Allergy Clin. Immunol., 79:113 (1987). (8 pages) Cited by 6 patents
  • Hoffman, J. Allergy and Clin. Immunol., 75:611 (1985). (3 pages) Cited by 6 patents
  • King, et al., J. Allergy and Clin. Immunol., 75:621 (1985). (8 pages) Cited by 8 patents


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