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Title: US6107540: Mice models of human prostate cancer progression
[ Derwent Title ]

Country: US United States of America

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25 pages

 
Inventor: Sawyer, Charles L.; Los Angeles, CA
Klein, Karen A.; Los Angeles, CA
Witte, Owen N.; Sherman Oaks, CA
Reiter, Robert E.; Los Angeles, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-08-22 / 1997-10-15

Application Number: US1997000951143
IPC Code: Advanced: A01K 67/027; C12N 15/09; C12Q 1/02;
Core: more...
IPC-7: A61K 49/00; C12N 5/00; C12N 15/00; G01N 31/00;

ECLA Code: A01K67/027B;

U.S. Class: Current: 800/010; 424/009.2; 435/455; 514/044.R; 800/018;
Original: 800/010; 424/009.21; 435/455; 514/044;

Field of Search: 800/010 424/9.21 435/455 514/044

Government Interest:     This invention was made with Government support under Grant No. GM-08243, awarded by the National Institute of Health. The Government has certain rights in this invention.

Priority Number:
1997-10-15  US1997000951143
1996-10-15  US1996000732676

Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.

Attorney, Agent or Firm: Mandel & AdrianoLaw Offices of Kenneth K. Sharples ;

Primary / Asst. Examiners: Crouch, Deborah; Martin, Jill D.
INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

       
Related Applications: Go to Result Set: 12 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1996000732676 1996-10-15       


       
Parent Case:     This application is a continuation-in-part of U.S. Ser. No. 08/732,676, filed Oct. 15, 1996, now abandoned the contents of which is hereby incorporated by reference in its entirety.

Designated Country: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE  AU CA EP JP 

Family: Show 29 known family members
First Claim:
Show all 17 claims		 What is claimed is:     1. A method of simulating the progression of human prostate cancer from primary tumor formation to micrometastasis in an animal model comprising:
  • a. generating a human prostate cancer xenograft in an immune deficient mouse by implanting intraprostatically locally advanced or metastatic prostate cancer tissue, or a cell suspension thereof from a human into an immune deficient mouse; and
  • b. allowing the xenograft to grow for a time sufficient to permit the detection of prostate cancer cells within and external to the implant site in the immune deficient mouse thereby simulating the progression of human prostate cancer from primary tumor formation to micrometastasis in the animal model.
    •


Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 3 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (3)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: DERABS C2000-586223

Other References:
  • Liu, A. Y., et al., "Prostatic Cell Lineage Markers: Emergence of BCL2+ Cells of Human Prostate Cancer Xenograft LuCaP 23 Following Castration," Int. J. Cancer, 65:85-89 (1996). (5 pages) Cited by 7 patents [ISI abstract]
  • Lubaroff, D. M., et al., "Survival of Human Prostate Carcinoma, Benign Hyperplastic Prostate Tissues, and IL-2-Activated Lymphocytes in SCID Mice," The Prostate, 27:32-41 (1995). (10 pages) Cited by 8 patents [ISI abstract]
  • Wainstein, M. A., et al., "CWR22: Androgen-Dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma," Cancer Research, 54:6049-6052 (1994). (4 pages) Cited by 15 patents [ISI abstract]
  • Pretlow, T. G., et al., "Xenografts of Primary Human Prostatic Carcinoma," Journal of the National Cancer Institute, 85(5):394-398 (1993). (9 pages) Cited by 8 patents [ISI abstract]
  • Pretlow, T. G. et al., "Transplantation of Human Prostatic Carcinoma into Nude Mice in Matrigel," Cancer Research, 51:3814-3817 (1991). (4 pages) Cited by 8 patents [ISI abstract]
  • Perez-Stable et al., Cancer Research, vol. 57, pp. 900-906. (Mar. 1, 1997). (7 pages) Cited by 9 patents [ISI abstract]
  • Sato et al., Journal of Urology, vol. 155; 5, p. 338A. (May 4, 1996).
  • van Weerden et al., American Journal of Pathology, vol. 149: 3, pp. 1055-1062. (Sep. 1996). (8 pages) Cited by 2 patents [ISI abstract]


    • Continuity Data:
    Application Number Filed Notes
    US1997000951143 1997-10-15  is a related to the prior publication
         US20020083478A1 issued 2002-06-27  Mice models of human prostate cancer progression
    US1997000951143 1997-10-15  is a related to the prior publication
         US20020129390A1 issued 2002-09-12  Methods of assessing the effect of a gene of interest on human prostate cancer progression
    US1997000951143 1997-10-15  is a related to the prior publication
         US20020138861A1 issued 2002-09-26  Mice models of human prostate cancer progression
    US1997000951143 1997-10-15  is a related to the prior publication
         US20020144301A1 issued 2002-10-03  Purified human prostate cancer cells
    US1997000951143 1997-10-15  is a related to the prior publication
         US20070006331A1 issued 2007-01-04  MOUSE MODELS OF HUMAN PROSTATE CANCER
    US2006000531212 2006-09-12  is a continuation of
    US2002000067705  2002-02-04   (granted)
         US7122714 issued 2006-10-17   Mouse models of human prostate cancer
    11531212   is a continuation of
    US2002000067705  2002-02-04
         US7122714 issued 2006-10-17   Mouse models of human prostate cancer
    US2002000067705 2002-02-04  is a division of
    US2000000567202  2000-05-08   (granted)
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000067705 2002-02-04  is a continuation of
    US2000000567202  2000-05-08   (granted)
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000067705   is a continuation of
    US2000000567202  2000-05-08
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000066266 2002-01-30  is a division of
    US2000000567202  2000-05-08   (granted)
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000066266   is a continuation of
    US2000000567202  2000-05-08
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000062925 2002-01-30  is a division of
    US2000000567202  2000-05-08   (granted)
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000062738 2002-01-30  is a division of
    US2000000567202  2000-05-08   (granted)
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000062738   is a continuation of
    US2000000567202  2000-05-08
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2002000062684 2002-01-30  is a division of
    US2000000567202  2000-05-08   (patented) [presumed granted]
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2001000022115 2001-12-14  is a division of
    US2000000567202  2000-05-08   (pending) [presumed granted]
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2001000022115   is a continuation of
    US2000000567202  2000-05-08
         US6365797 issued 2002-04-02   Mice models of human prostate cancer progression
    US2000000567202 2000-05-08  is a division of
    >US1997000951143<  1997-10-15   (granted)
         US6107540 issued 2000-08-22   Mice models of human prostate cancer progression
    US2000000567202 2000-05-08  is a division of
    >US1997000951143<  1997-10-15   (patented) [presumed granted]
         US6107540 issued 2000-08-22   Mice models of human prostate cancer progression
    US2000000567202   is a division of
    >US1997000951143<  1997-10-15
         US6107540 issued 2000-08-22   Mice models of human prostate cancer progression
    >US1997000951143< 1997-10-15  is a continuation in part of
    US1996000732676  1996-10-15   (abandoned)
    >US1997000951143<   is a continuation in part of
    US1996000732676  1996-10-15   (abandoned)


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