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Title: US6110740: Human vault RNA
[ Derwent Title ]

Country: US United States of America

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17 pages

 
Inventor: Rome, Leonard H.; Tarzana, CA
Kickhoefer, Valerie A.; Sherman Oaks, CA

Assignee: Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-08-29 / 1999-03-26

Application Number: US1999000276975
IPC Code: Advanced: C07K 14/47; A61K 38/00;
Core: C07K 14/435; more...
IPC-7: C07H 21/02; C07H 21/04; C12N 15/63; C12N 15/85; C12Q 1/68;

ECLA Code: C07K14/47;

U.S. Class: Current: 435/325; 435/006; 435/091.1; 435/252.3; 435/320.1; 536/023.1; 536/023.51; 536/024.3; 536/024.31; 536/024.33;
Original: 435/325; 435/006; 435/091.1; 435/252.3; 435/320.1; 536/023.1; 536/023.51; 536/024.3; 536/024.31; 536/024.33;

Field of Search: 435/006,91.1,440,375,325 536/23.1,23.2,29.5,24.3 514/044

Government Interest:

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
    The present invention was made with government support under Grant No. GM 38097, awarded by the National Institutes of Health. The United States Government has certain rights in this invention.

Priority Number:
1999-03-26  US1999000276975
1998-03-27  US1998000079634P

Abstract: A polynucleotide encoding a human vault-associated vRNA or its complementary strand. A purified and isolated polynucleotide molecule consisting essentially of a human vault RNA, or its complementary strands, or a combination of a nucleotide sequence consisting essentially of a human vault RNA and its complementary strands. A method of diagnosing a patient with a multidrug-resistant cancer. A method of treating a patient with multidrug-resistant cancer. A composition for treating multidrug-resistant cancer comprising a polynucleotide which hybridizes with a human vault-associated vRNA. A method of screening for compositions for treating a patient with multidrug-resistant cancer.

Attorney, Agent or Firm: Farah, David A.Sheldon & Mak ;

Primary / Asst. Examiners: Elliott, George C.; Epps, Janet
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Parent Case:

CROSS-REFERENCE TO RELATED APPLICATION
    This application claims priority under 35 U.S.C. 119(e) to provisional U.S. patent application Ser. No. 60/079,634, entitled "Human Vault RNA," filed Mar. 27, 1998.

Designated Country: AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ 

Family: Show 8 known family members
First Claim:
Show all 20 claims		 We claim:     1. An isolated polynucleotide encoding a human vault-associated vRNA or its complementary strand.

Background / Summary: Show background / summary

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U.S. References: Go to Result Set: No U.S. references   |  No patents reference this one   |   Backward references (0)

       
Foreign References:
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PDF		 Publication Date IPC Code Assignee   Title
  WO1996WO027611A 1996-09       


Other Abstract Info: CHEMABS 131(18)239482U

Other References:
  • Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
  • Trisha Gura, Antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995. (3 pages) Cited by 302 patents [ISI abstract]
  • Stanley Crooke, Antisense '97: A roundtable on the state of the Industry, Nature Biotechnology, p. 522, Jun. 1997.
  • Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, p. 3, Jul. 1998.
  • Chugani, Diane C. et al. Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. Journal of Cell Science, 1993, 106:23-29. (7 pages) [ISI abstract]
  • George, David G. et al. Current Methods in Sequence Comparison and Analysis. Macromolecular Sequencing and Synthesis Selected Methods and Applications, 1988, pp. 127-149, Alan R. Liss, Inc., New York.
  • Kickhoefer, Valerie A. et al. Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines. J. Biol. Chem. 273:8971-8974, Apr. 1998. (4 pages) Cited by 3 patents [ISI abstract]
  • Kickhoefer, Valeria A. et al. Vault Ribonucleoprotein Particles from Rat and Bullfrog Contain a Related Small RNA That is Transcribed by RNA Polymerase III. The Journal of Biological Chemistry, Apr. 1993, vol. 268, No. 11, pp. 7868-7873. (6 pages) Cited by 9 patents [ISI abstract]
  • Rome, Leonard H. Multidrug resistance: Locked in the vault? Nature Medicine, 1995, vol. 1, No. 6, p. 527. (1 pages) [ISI abstract]
  • Rome, Leonard et al. Unlocking vaults: organielles in search of a function. Trends in Cell Biology, 1991, vol. 1, No. 213, pp. 47-50.
  • Scheffer, George L. et al. The drug resistance-related protein LRP is the human major vault protein. Nature Medicine, 1995, vol. 1, No. 6, pp. 578-582. (5 pages) Cited by 13 patents [ISI abstract]
  • Mart. S.M. et al., "Expression of the human major vault protein LRP in acute myeloid leukemia", Experimental Hematology, 25(12):1227-1232, Nov. 1997.
  • Irman, E.M. et al., "Targeted Degradation of the Vault RNA (vRNA) in vivo Using Antisense Oligodeoxynucleotides," Molecular Biology of the Cell, vol. 6, Suppl., p. 196a, 1995.
  • Izquierdo, M.A. et al., "Relationship of LRP-human major vault protein to in vitro and clinical resisttance to anticancer drugs," Cytotechnology, 19(3):191-197, 1996. (7 pages) Cited by 3 patents [ISI abstract]
  • Kickhoefer, V.A. et al., "Multidrug resistant cancer cell lines contain elevated levels of vaults," Proceedings of the American Association for Cancer Research Annual Meeting, 38:252, 1997.
  • Kickhoefer, V.A. et al., "Vaults are the answer, what is the question?," Trends in Cell Biology, 6(5):174-178 1996. (5 pages) Cited by 3 patents [ISI abstract]


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