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 Title: |
US6133232:
Endoderm, cardiac and neural inducing factors
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
De Robertis, Edward M.; Pacific Palisades, CA
Bouwmeester, Tewis; Heidelberg, Germany
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-10-17
/ 1997-06-18
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| Application Number: |
US1997000878474
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| IPC Code: |
Advanced:
C07K 14/475;
C07K 19/00;
C12N 15/09;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
A61K 38/18;
C07K 14/46;
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| ECLA Code: |
C07K14/475;
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| U.S. Class: |
Current:
514/012;
424/198.1;
530/350;
Original:
514/012;
424/198.1;
530/350;
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| Field of Search: |
514/012
424/198.1
530/350
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| Government Interest: |
This invention was made with Government support under grant contract number HD-21502, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
| 1997-06-18 |
US1997000878474 |
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| Abstract: |
Two novel proteins have been designated "cerberus" and "frzb-1," respectively. Cerberus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is designated "PAPC" which promotes the formation of dorsal mesoderm and somites in the embryo.
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| Attorney, Agent or Firm: |
Majestic, Parsons, Siebert & Hsue P.C. ;
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| Primary / Asst. Examiners: |
Romeo, David; Kemmerer, Elizabeth
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This application claims the benefit of U.S. Provisional application Ser. No. 60/020,150 filed Jun. 20, 1996.
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| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE AU CA EP JP
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| Family: |
Show 18 known family members
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First Claim:
Show all 10 claims |
It is claimed:
1. A substantially pure protein comprising either the amino acid sequence of SEQ ID NO:1 or a fragment thereof, wherein said fragment has neurotrophic, growth or differentiation factor activity in Xenopus embryos, and wherein said protein does not dorsalize Xenopus mesoderm.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 9 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 128(09)098574Z
DERABS C1998-062760
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| Other References: |
Ham et al. Media and growth requirements. Methods Enzymology, (Mar. 1979), vol. 58, pp. 44-93.
Bouwmeester et al., "Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer," Nature, 382:6592, pp. 595-601 (Aug. 15, 1996).
(7 pages)
Cited by 15 patents
[ISI abstract]
Christian et al., "Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus," Genes & Development, pp. 13-28 (1993).
(16 pages)
Cited by 6 patents
[ISI abstract]
Gribskov et al, "[9] Profile Analysis," Methods of Enzymology, 183, pp. 146-159 (1990).
(14 pages)
Cited by 3 patents
Krasnow et al., "dishevelled is a component of the frizzled signaling pathway in Drosophila," Development, 121, pp. 4095-4102 (1995).
(8 pages)
[ISI abstract]
Leyns et al., "Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer," Cell, 88, pp. 747-756 (Mar. 21, 1997).
(10 pages)
Cited by 21 patents
[ISI abstract]
Mayr et al., "Fritz: a secreted frizzled-related protein that inhibits Wnt activity," Mechanisms of Development, 63, pp. 109-125 (1997).
(17 pages)
Cited by 6 patents
[ISI abstract]
Moon et al., "Structural Related Receptors and Antagonists Compete for Secreted Wnt Ligands," Cell, 88, pp. 725-728 (Mar. 21, 1997).
(4 pages)
Cited by 3 patents
[ISI abstract]
Sano et al., "Protocadherins: a large family of cadherin-related molecules in central nervous system," The EMBO Journal, 12:6, pp. 2249-2256 (1993).
(8 pages)
Cited by 17 patents
[ISI abstract]
Sasai et al., "Xenopus chordin: A Novel Dorsalizing Factor Activated by Organizer-Specific Homeobox Genes," Cell, 79, pp. 779-790 (Dec. 2, 1994).
(12 pages)
Cited by 19 patents
[ISI abstract]
Sasai et al., "Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus," Nature, 376, pp. 333-336 (Jul. 27, 1995).
(4 pages)
Cited by 15 patents
[ISI abstract]
Sokol et al., A Mouse Macrophage Factor induces Head Structures and Organizes a Body Axis in Xenopus, Science, 249, pp. 561-564 (Aug. 3, 1990).
(4 pages)
Cited by 23 patents
Smith et al., "Injection Xwnt-8 RNA Acts Early in Xenopus Embryos to Promote Formation of a Vegetal Dorsalizing Center," Cell67, pp. 753-765 (Nov. 15, 1991).
(13 pages)
Cited by 15 patents
[ISI abstract]
Smith et al., "Expression Cloning of noggin, A new Dorsalizing Factor Localized to the Spemann Organizer in Xenopus Embryos," Cell, 70 , pp. 829-840 (Sep. 4, 1992).
(12 pages)
Cited by 12 patents
[ISI abstract]
Vinson et al., "A Drosophilia tissue polarity locus encodes a protein containing seven potential transmembrane domains," Nature, 338, pp. 263-264 (Mar. 16, 1989).
(2 pages)
Cited by 7 patents
Vinson et al., "Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drospohila," Nature, 329 pp. 549-551 (Oct. 8, 1987).
(3 pages)
Cited by 6 patents
Wang et al., "A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophilia Tissue Polarity Gene frizzled," J. of Biol. Chem., 271:8, pp. 4468-4476 (Feb.23, 1996).
(9 pages)
Cited by 15 patents
[ISI abstract]
Wang et al. "Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8," Cell, 88, pp. 757-766 (Mar. 21, 1997).
(10 pages)
Cited by 13 patents
[ISI abstract]
Nathan C; Sporn M. Cytokines in context. J. Cell Biol., (Jun. 1991) 113 (5) 981-986.
(6 pages)
Cited by 35 patents
[ISI abstract]
Marieb E N. In, Human Anatomy and Physiology, Second Edition. 1992. The Benjamin/Cummings Publishing Co., Inc. pp. 373-375.
Daniel et al. Virology, (Aug. 1, 1994) 202 (2) 540-549.
(10 pages)
Cited by 46 patents
[ISI abstract]
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