Work Files Saved Searches
   My Account                                                  Search:   Quick/Number   Boolean   Advanced   Derwent    Help   


 The Delphion Integrated View

  Buy Now:   Buy PDF- 22pp  PDF  |   File History  |   Other choices   
  Tools:  Citation Link  |  Add to Work File:    
  View:  Expand Details   |  INPADOC   |  Jump to: 
  Go to:  Derwent  
 Email this to a friend  Email this to a friend 
       
Title: US6140083: Leptospiral outer membrane protein, LipL46
[ Derwent Title ]


Country: US United States of America

View Images High
Resolution

 Low
 Resolution

 
22 pages

 
Inventor: Haake, David A.; Culver City, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
 News, Profiles, Stocks and More about this company

Published / Filed: 2000-10-31 / 1998-07-23

Application Number: US1998000122210

IPC Code: Advanced: C07K 14/20; A61K 39/00;
Core: C07K 14/195; more...
IPC-7: C12P 21/06;

ECLA Code: C07K14/20;

U.S. Class: Current: 435/069.3; 435/252.3; 435/320.1; 530/350; 536/023.1; 536/023.7;
Original: 435/069.3; 435/252.3; 435/320.1; 536/023.1; 536/023.7; 530/350;

Field of Search: 536/23.1,23.7 435/252.3,69.3,320.1,325 530/350

Government Interest:     This invention was made with Government support under Grant No. AI34431, awarded by the National Institute of Health. The Government has certain rights in this invention.

Priority Number:
1998-07-23  US1998000122210

Abstract: An antigenic preparation is provided containing an outer membrane protein associated with pathogenic strains of Leptospira. The protein has been designated "LipL46" for "lipoprotein from Leptospira" and because the isolated polypeptide migrates to a position corresponding to a molecular weight of 46 kD in a denaturing polyacrylamide gel. The invention provides polynucleotides encoding LipL46 and antibodies that bind the protein which are useful in the diagnosis of leptospirosis. In addition, LipL46 can be used immunologically as a vaccine for spirochete-associated pathologies.

Attorney, Agent or Firm: Gray Cary Ware & Freidenrich LLP ; Haile, Lisa A. ;

Primary / Asst. Examiners: Stucker, Jeffrey;

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

Designated Country: AE AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR 

Family: Show 4 known family members

First Claim:
Show all 14 claims
What is claimed is:     1. An isolated polynucleotide encoding an amino acid sequence as set forth in SEQ ID NO:2.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

       
U.S. References: Go to Result Set: All U.S. references   |  No patents reference this one   |   Backward references (11)   |   Citation Link

Buy
PDF
Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 23pp US4366246  1982-12 Riggs  Genentech, Inc. Method for microbial polypeptide expression
Buy PDF- 9pp US4474893  1984-10 Reading  The University of Texas System Cancer Center Recombinant monoclonal antibodies
Buy PDF- 10pp US4676980  1987-06 Segal et al.  The United States of America as represented by the Secretary of the Department of Health and Human Services Target specific cross-linked heteroantibodies
Buy PDF- 11pp US5091301  1992-02 Zuerner  The Unites States of America as represented by the Secretary of Agriculture Diagnostic and epidemiological nucleic acid probe for bovine leptospirosis
Buy PDF- 22pp US5397698  1995-03 Goodman et al.  Syntex (U.S.A.) Inc. Amplification method for polynucleotide detection assays
Buy PDF- 23pp US5401631  1995-03 Lane et al.  Amoco Corporation Universal eubacteria nucleic acid probes and assay methods
Buy PDF- 13pp US5466577  1995-11 Weisburg  Amoco Corporation Nucleic acid probes for the detection of Lyme disease spirochetes
Buy PDF- 14pp US5516641  1996-05 Ullman et al.  Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
Buy PDF- 23pp US5643754  1997-07 Haake  The Regents of the University of California Nucleic acids encoding a leptospira outer membrane protein
Buy PDF- 19pp US5658757  1997-08 Haake et al.  The Regents of the University of California Cloned leptospira outer membrane protein
Buy PDF- 23pp US5824321  1998-10 Haake et al.  The Regents of the University of California Cloned leptospira outer membrane protein
       
Foreign References:
Buy
PDF
Publication Date IPC Code Assignee   Title
Buy PDF- 60pp WO9532220 1995-11  C07K 14/20 THE REGENTS OF THE INIVERSITY OF CALIFORNIA CLONED LEPTOSPIRA OUTER MEMBRANE PROTEIN 
Buy PDF- 36pp WO9626274 1996-01  C12N 15/09 IMMUNEX CORPORATION ANTAGONISTS OF INTERLEUKIN-15 
Buy PDF- 68pp WO9636355 1996-11  A61K 39/02 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA LEPTOSPIRA MEMBRANE PROTEINS 


Other Abstract Info: CHEMABS 132(11)136416S DERABS C2000-195094

Other References:
  • Blanchard-Channell, et al., Infection and Immunity, No. 8, 59:2790-2798, Aug. 1991, Characterization of Borrelia coriaseae Antigens with Monoclonal Antibodies. (9 pages) Cited by 4 patents [ISI abstract]
  • Allan, et al. Infection and Immunity, No. 3, 45:637-641, Sep. 1984, Molecular Cloning of the Major Outer Membrane Protein of Chlamydia Trachamatis. (5 pages) Cited by 8 patents
  • Haake, et al., Infection and Immunity, No. 3, 59:1131-1140m, Mar. 1991, "Changes in the Surface of Leptospira Interrogans Serovar Grippotyphosa during in Vitro Cultivation". (10 pages) Cited by 6 patents [ISI abstract]
  • Zuerner, et al., Microbial Pathogenesis, 10:311-322, 1991, Characterization of outer membrane and secreted proteins of Leptospira serovar pomona. (12 pages) Cited by 9 patents [ISI abstract]
  • Van Eys et al., "DNA Hybridization . . . Leptospira.", J Gen. Microbiol. 134:567-574 (Mar. 1998).
  • Yasuda et al., "Doxyribonucleic Acid Relatedness Between Serograys and serovan in the family Leptospiraceae . . . "Int. J. SN Bact. 37(4):407-415 (Oct. 1987). (9 pages) Cited by 6 patents
  • Bolin, C.A., et al., "Effect of vaccination with a pentavalent leptospiral vaccine on Leptospira interrogans serovar hardjo type hardjo-bovis infection of pregnant cattle", Am.J.Vet. Res., 50:161 (1989). (5 pages) Cited by 4 patents
  • Bolin, C.A., et al., "Effect of vaccination with a pentavalent leptospiral vaccine containing leptospira interrogans serovar hardjo type hardjo-bovis on type hardjo-bovis infection of cattle", Am.J. Vet. Res., 50:2004 (1989). (5 pages) Cited by 3 patents
  • Bolin, C.A., "effect of vaccination with a monovalent leptospira interrogans serovar hardjo type hardjo-bovis vaccine on type hardjo-bovis infection of cattle", et al., Am. J. Vet. Res., 52:1639-1643 (1991). (5 pages) Cited by 4 patents [ISI abstract]
  • Brandt, et al., "Immunogenic Integral Mambrane Proteins of Borrelia burgdorferi Are lipoproteins", Infect. Immun. 58:983-991 (1990). (9 pages) Cited by 24 patents
  • Chamberlain, N.R., et al., "Major Integral Membrane Protein Immunogens of Treponema pallidum Are proteolipids", Infect. Immun., 57:2872-2877 (1989). (6 pages) Cited by 4 patents
  • Cunningham, et al., "Selective Release of the Treponema pallidum Outer membrane and Associated Polypeptides with Triton X-144", J. Bacteriol., 170:5789-5796 (1988). (8 pages) Cited by 7 patents
  • Doherty, J.P., et al., "Expression of two conserved leptospiral antigens in Escherichia coli", J. Med. Microbiol, 28:143-149 (1989). (7 pages) Cited by 4 patents
  • Farr, R.W., "Leptospirosis", State-Of-The-Art Clinical Article, Clinical infectious Diseases, 21:1 (1995). (6 pages) Cited by 5 patents [ISI abstract]
  • Haake, D.A., et al., "Molecular Cloning and Sequence Analysis of the Gene Encoding OmpL 1, a Transmembrane Outer Membrane Protein of Pathogenic Leptospira spp.", J. Bacteriol., 175(13):4225-4234 (Jul. 1993). (10 pages) Cited by 8 patents [ISI abstract]
  • Hayashi, S., et al., Lipoproteins in Bacteria, J. Bioenerg. Biomembr., 22:451 (1990). (21 pages) Cited by 10 patents
  • Miyamoto, M., et al., "molecular Cloning and Sequence Analysis of Antigen Gen tdpA of Treponema denticola", Infect. Immun., 59:1941-1947 (1991). (7 pages) Cited by 4 patents [ISI abstract]
  • Ramadass, P., et al, "Genetic Characterizationof pathogenic Species by DNA Hybridization", Int'l J. Of Systematic Bacteriol., 42:215-219 (1992). (5 pages) Cited by 4 patents [ISI abstract]
  • Stamm, et al., "Changes in the Cell Surface Properties of Treponema pallidum That occur during in Vitro Incubation of Freshly Extracted Organisms", Infec. Immun. 55:2255-2261 (1987). (7 pages) Cited by 5 patents
  • Thiermann, et al., "Leptospirosis: Current Developments and trends", J. Am. Vet. Med. Assoc., 184:722(1984). (4 pages) Cited by 5 patents
  • Thomas, W., et al., "Molecular Cloning, Expression, and DNA Sequence Analysis of the Genes That Enclodes the 16-Kilodalton Outer Membrance Lipoprotein of Serpulina hyodysenteriae", Infect. Immun., 61-1136 (1993).
  • Van Eys, G.J.J.M., et al., "DNA Hybridization with Hardjobovis-specific Recombinant Probes as a Method for Type Discrimination of Leptospira interrogans Serovar hardjo", J. Of Gen. Microbiology, 134:567 (1988). (8 pages) Cited by 5 patents
  • Cinco, M., et al., "Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis", FEMS Microbiology Letters, 89:287-298 (1992). (11 pages) Cited by 4 patents [ISI abstract]
  • Brown, et al., "Protein and Antigen Profiles of Prevalent Serovars of Leptospira interrogans", Infection and Immunity, vol. 59., No. 5, pp. 1772-1777, issued May, 1991. (6 pages) Cited by 7 patents [ISI abstract]
  • Gitton, et al., Immunoblotting study of the antigenic relationships among eight serogroups of Leptospira, Veterinary Microbiology, vol. 32, issued 1992, pp. 293-303. (11 pages) Cited by 3 patents [ISI abstract]
  • Nicholson, Vivian and Prescott, John, Outer Membrane proteins of three pathogenic Leptospira species, Veterinary microbiology, 36, pp. 123-138, (1993). (16 pages) Cited by 7 patents [ISI abstract]
  • Nunes-Edwards, et al., Identification and Characterization of the Protein Antigens of Leptospira interrogans serovar hardjo, Infection and Immunity, vol. 48, No. 2, pp. 492-497, May 1985. (6 pages) Cited by 5 patents
  • Auran, et al., "Isolation of the Outer Sheath of Leptospira and its Immunogenic Properties in Hamsters", Infect. Immun., 5:968-975 (1972). Cited by 2 patents
  • Bey, R.F., et al., "Immunognicity of Whole Cell and Outer Envelope Leptospiral Vaccines in Hamsters", Infect. Immun., 10:1051-1056 (1974). (6 pages) Cited by 3 patents
  • Blanco, et al., "Isolation of the Outer Membranes from Treponema pallidum and Treponema vincenti", J. Bateriol., 176:6088-6099 (1994). (12 pages) Cited by 5 patents [ISI abstract]
  • Holt, S.C., "Anatomy and Chemistry of Spirochetes", Microbiol. Rev., 42:114-160 (1978). (47 pages) Cited by 3 patents
  • Osborn, et al., "Mechanism of Assembly of the Outer Membrane of Salmonella typhimurium", J. Biol. Chem., 247:3962-3972 (1972). Cited by 4 patents
  • Penn, et al., "The Outer Membrane of Treponema pallidum: Biological Significance and Biochemical Properties", J. Gen. Microbiol., 131:2349-2357 (1985). (9 pages) Cited by 7 patents
  • Radolf, et al., "Characterization of Outer Membranes Isolated from Borrelia burgdorferi, the Lyme Desease Spirochete", Infect. Immun., 63:2154-2163 (1995). (10 pages) Cited by 3 patents [ISI abstract]
  • Radolf, et al., "Characterization of Outer Membrances Isolated from Treponema pallidum, the Syphilis Spirochete", Infect. Immun. 63:4244-4252 (1995). (9 pages) Cited by 3 patents [ISI abstract]
  • Shang, E.S. et al., "The Rare Outer Membrane Protein, OmpL1, of Pathogenic Leptospira Species is a Heat-Modifiable Porin", Infect. Immun. 63(8):3174-3181 (1995). (8 pages) Cited by 4 patents [ISI abstract]
  • Shang, E.S., et al., "Molecular Cloning and Sequence Analysis of the Gene Encoding LipL41, and Surface-Exposes Lipoprotein of Pathogenic Leptospira Species", Infect. Immun. 64:2322-2330 (1996). (9 pages) Cited by 5 patents [ISI abstract]
  • Weigel, L.M., et al., "The 47-kDa major lipoprotein immunogen of Treponema pallidum is a penicillin-binding protein with carboxypeptidase activity", Proc. Natl. Acad. Sci. USA, 91:11611-11615 (1994). (5 pages) Cited by 3 patents [ISI abstract]
  • Champion, et al., Infect. Immun 62(7):2653-2661 (Jul. 1994). (9 pages) Cited by 3 patents [ISI abstract]


  • Inquire Regarding Licensing

    Powered by Verity


    Plaques from Patent Awards      Gallery of Obscure PatentsNominate this for the Gallery...

    Thomson Reuters Copyright © 1997-2010 Thomson Reuters 
    Subscriptions  |  Web Seminars  |  Privacy  |  Terms & Conditions  |  Site Map  |  Contact Us  |  Help