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 Title: |
US6147191:
Oligodendrocyte-specific protein
[ Derwent Title ]
>> View Certificate of Correction for this publication
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| Country: |
US United States of America
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| Inventor: |
Seitz, Robert S.; Huntsville, AL
Lallone, Roger L.; Birmingham, AL
Bronstein, Jeff M.; Santa Monica, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-11-14
/ 1998-05-26
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| Application Number: |
US1998000084153
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| IPC Code: |
Advanced:
C07K 14/47;
C07K 16/18;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
C07K 1/00;
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| ECLA Code: |
C07K14/47A5; C07K16/18;
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| U.S. Class: |
Current:
530/350;
Original:
530/350;
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| Field of Search: |
530/350
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| Government Interest: |
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
This invention was made with Government support under Grant No. NS01596, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
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| Abstract: |
A protein consisting essentially of purified oligodendrocyte-specific protein or purified biologically active variants thereof, or a combination of purified oligodendrocyte-specific protein and biologically active variants thereof. A purified and isolated peptide having the sequence Ala-Lys-Tyr-Arg-Arg-Ala-Gln-Leu-Ala-Gly, residues 115-124 of SEQ ID NO:2. A device for identifying an epitope region of a peptide, protein, or protein homologue of interest comprising a polypropylene membrane having a plurality of sequentially oriented peptide spots, each spot containing a peptide having an amino acid sequence where the amino acid sequences of the peptides on the peptide spots sequentially progress through the amino acid sequence of the peptide, protein, or protein homologue of interest. A method of diagnosing multiple sclerosis and a method of treating multiple sclerosis. A method of diagnosing a disease or condition, such as an autoimmune disease, the disease or condition having the clinical feature of antibody production against a peptide, protein, or protein homologue.
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| Attorney, Agent or Firm: |
Farah, David A.Sheldon & Mak ;
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| Primary / Asst. Examiners: |
Caputa, Anthony C.; Navarro, Mark
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| Maintenance Status: |
E1 Expired Check current status
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 134(01)001358V
DERABS C1997-289056
DERABS C2001-040476
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| Other References: |
Buznikov, A. et al., "Cloning Of The Human Oligodendrocyte-Specific Protein (OSP) Homologue," Dept. Of Neurology And Pharmacology And The Brain Research Institute, UCLA School of Medicine, Los Angeles, CA-Abstract and Poster From Society For Neuroscience Meeting, Nov. of 1996.
Pham-Dinh, D. et al., "Characterization and Expression of the cDNA Coding for the Human Myelin/Oligodendrocyte Glycoprotein," Journal of Neurochemistry, 63(6);2353-2356 (1994).
(4 pages)
Cited by 5 patents
[ISI abstract]
Schaeren-Wiemers, N. et al., "Identification of New Oligodendrocyte- and Myelin-Specific Genes by a Differential Screening Approach," Journal Of Neurochemistry, 65(1):10-22, 1995.
(13 pages)
Cited by 2 patents
[ISI abstract]
Schaefer et al., "The C-DNA of COP, A novel oligodendrocyte-specific protein," Experientia, 49:A66 (1993).
Sevier, E.D. et al., "Monoclonal Antibodies in Clinical Immunology," Clinical Chemistry, 27(11):1797-1805 (1981).
(10 pages)
Cited by 283 patents
Xie, D. et al., "The oligodendroglial reaction to brain stab wounds: an immunohistochemical study," Journal Of Neurocytology, 24:435-448 (1995).
(14 pages)
Cited by 3 patents
[ISI abstract]
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