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 Title: |
US6153194:
Borrelia burgdorferi outer membrane proteins
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Skare, Jonathan T.; College Station, TX
Shang, Ellen S.; Calabasas, CA
Champion, Cheryl I.; Los Angeles, CA
Blanco, David R.; Calabassas, CA
Miller, James N.; Northridge, CA
Lovett, Michael A.; Los Angeles, CA
Mirzabekov, Tajib A.; Newton, MA
Kagan, Bruce L.; Pacific Palisades, CA
Tempst, Paul; New York, NY
Foley, Denise M.; Orange, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2000-11-28
/ 1998-10-29
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| Application Number: |
US1998000183217
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| IPC Code: |
Advanced:
G01N 33/569;
Core:
more...
IPC-7:
A61K 39/00;
A61K 39/02;
C07K 1/00;
G01N 33/554;
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| ECLA Code: |
G01N33/569D;
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| U.S. Class: |
Current:
424/184.1;
424/234.1;
435/007.32;
530/350;
Original:
424/184.1;
424/234.1;
435/007.32;
530/350;
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| Field of Search: |
424/184.1,234.1
530/350
435/7.32
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| Government Interest: |
This invention was made with Government support through funding from the National Institutes of Health ("NIH") under NIH Grant Nos. Al 21352, Al 29733, Al 12601 and Al 37312. The Government has certain rights in this invention.
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| Priority Number: |
| 1998-10-29 |
US1998000183217 |
| 1997-01-21 |
US1997000787367 |
| 1996-01-22 |
US1996000010321P |
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| Abstract: |
The present invention presents three B. burgdorferi membrane proteins: Oms28, Oms45, and Oms66, each of about 28, 45, and 66 kDa respectively; and with average single channel conductances of about 0.6, 0.22, and 9.7 nS, respectively. Also disclosed are the methods for purifying these proteins from B. burgdorferi, methods for producing antibodies to these proteins, and the resulting antibodies. These proteins and their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to pathogenic B. burgdorferi as well as providing a diagnostic target for Lyme disease. Further disclosed are the nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, and methods for obtaining the foregoing. Other B. burgdorferi outer membrane spanning proteins (Oms) obtainable by the isolation and purification methods of the present invention.
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| Attorney, Agent or Firm: |
Fulbright & Jaworski L.L.P. ;
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| Primary / Asst. Examiners: |
Housel, James C.; Ryan, V.
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| INPADOC Legal Status: |
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