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Title: US6156879: Human minor vault protein p193
[ Derwent Title ]


Country: US United States of America

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24 pages

 
Inventor: Rome, Leonard H.; Tarzana, CA
Kickhoefer, Valerie A.; Sherman Oaks, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2000-12-05 / 1998-06-03

Application Number: US1998000089621

IPC Code: Advanced: C07K 14/47; C12Q 1/68; A61K 38/00;
Core: C07K 14/435; more...
IPC-7: A61K 38/17; C07K 14/47; C12Q 1/68; G01N 3/53;

ECLA Code: C07K14/47; C12Q1/68M6B;

U.S. Class: Current: 530/350; 435/006; 435/007.1; 530/358;
Original: 530/350; 530/358; 435/006; 435/007.1; 514/002;

Field of Search: 530/350,358 435/006,7.1 514/002

Government Interest:

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
    The present invention was made with government support under Grant No. GM 38097, awarded by the National Institutes of Health. The United States Government has certain rights in this invention.

Priority Number:
1998-06-03  US1998000089621

Abstract: A protein consisting essentially of purified human minor vault protein p193 or purified biologically active variants thereof, or a combination of purified human minor vault protein p193 and biologically active variants thereof. Also, a polynucleotide molecule encoding a protein which consists essentially of human minor vault protein p193, or its complementary strands. Further, there is provided a method of diagnosing and a method of treating patients with multidrug resistant cancer.

Attorney, Agent or Firm: Farah, Daivd A.Sheldon & Mak ;

Primary / Asst. Examiners: Johnson, Nancy A.;

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Family: Show 3 known family members

First Claim:
Show all 14 claims
What is claimed is:     1. A purified protein comprising an amino acid sequence as set forth in SEQ ID NO:2.

Background / Summary: Show background / summary

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U.S. References: Go to Result Set: No U.S. references   |  No patents reference this one   |   Backward references (0)

       
Foreign References:
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Publication Date IPC Code Assignee   Title
Buy PDF- 106pp WO9627611 1996-09  A61K 38/00 AKZO NOBEL N.V. A METHOD FOR IDENTIFYING A NOVEL MULTIDRUG-RESISTANCE TYPE 


Other Abstract Info: CHEMABS 134(03)026097X CHEMABS 134(03)026097X DERABS C2001-090170 DERABS C2001-090170

Other References:
  • Kedersha, Nancy L. et al., "Vaults.III. Vault Ribonucleoprotein Particles Open into Flower-like Structures with Octagonal Symmetry," The Journal of Cell Biology 112(2):225-235 (1991). (11 pages) Cited by 2 patents [ISI abstract]
  • Kickhoefer, Valerie A. et al., "Vaults are the answer, what is the question?" trends in Cell Biology 6:174-178(1996). (5 pages) Cited by 3 patents [ISI abstract]
  • Ruf, Armin et al., "Structure of the catalytic fragment of poly(ADP-ribose) polymerase from chicken," Proc. Natl. Acad. Sci. USA 93:7481-7485 (1996). (5 pages) Cited by 18 patents [ISI abstract]
  • Scheffer, George L. et al., "The drug resistance-related protein LRP is the human major vault protein," Nature Medicine 1(6):578-582 (1995). (5 pages) Cited by 13 patents [ISI abstract]
  • Simonin Frederic et al., "The Carboxyl-terminal Domain of Human Poly(ADP-ribose) Polymerase," The Journal of Biological Chemistry 268:(18):13454-13461 (1993). (8 pages) Cited by 2 patents [ISI abstract]
  • Sebolt-Leopold, Jr. et al. Enhancement of Alkylating Agent Activity in vitro by PD 128763, a Potent Poly(ADP-ribose) Synthetase Inhibitor. Int. J. Radiation Oncology Biol. Phys., 1992, vol. 222, pp. 619-621. (3 pages) Cited by 2 patents [ISI abstract]
  • Kim, K. et al. Tumor Suppressor Gene Expression during Normal and Pathologic Myocardial Growth. J. Biol. Chem., Sep. 09, 1994, vol. 269, No. 36, pp. 22607-22613. (7 pages) Cited by 2 patents [ISI abstract]
  • Kickhoefer, V. et al. Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines. J. Biol. Chem., Apr. 10, 1998, vol. 273, No. 15, pp. 8971-8974. (4 pages) Cited by 3 patents [ISI abstract]
  • Bork, Peer et al. A superfamily of conserved domains in DNA damage-responsive cell-cycle checkpoint proteins. The Faseb J. 11:68-76, 1997. (9 pages) Cited by 6 patents [ISI abstract]
  • Callebaut, Isabelle et al. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Letter 400:25-30, 1997. (6 pages) Cited by 5 patents [ISI abstract]
  • Golemis, Erica A. et al. Interaction Trap/Two-Hybrid System to Identify Interacting Proteins. Current Protocols in Mol. Biol. 20.1.1-20.35 John Willey & Sons, 1997.
  • Hart, S.M. et al., "Expression of the human major vault protein LRP in acute myeloid leukemia," Experimental Hematology, 25(12):1227-1232, Nov. 1997. (6 pages) Cited by 2 patents [ISI abstract]
  • Inman, E.M. et al., "Targeted Degradation of the Vault RNA (vRNA) in vivo Using Antisense Oligodeoxynucleotides," Molecular Biology of the Cell, vol. 6, Suppl., p. 196a.
  • Izquierdo, M.A. et al., "Relationship of LRP-human major vault protein to in vitro and clinical resisttance to anticancer drugs," Cytotechnology, 19(3):191-197, 1996. (7 pages) Cited by 3 patents [ISI abstract]
  • Kickhoefer, V.A. et al., "Multidrug resistant cancer cell lines contain elevated levels of vaults," Proceedings of the American Association for Cancer Research Annual Meeting, 38:252, 1997.
  • Kickhoefer, V.A. et al., "Vault Ribonucleoprotein Particles from Rat and Bullfrog Contain Related Small RNA That Is Transcribed by RNA Ploymerase III," The Journal of Biological Chemistry, 268(11):7868-7873, Apr. 15, 1993. (6 pages) Cited by 9 patents [ISI abstract]
  • "Bio-Critical Synergy: The Biotechnology Industry and IP Protection" pp. 75, 100-107, Presented Oct. 17, 1994, San Diego, CA Nagase, DNA Res 17:17-24, 1996.


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