Compositions and methods for treating and preventing microbial and viral infections (US6159936)

1998-08-03	US1998000128345
1995-07-07	US1995000499523
1994-05-17	US1994000243879
1994-01-13	US1994000182483
1993-07-26	US1993000095769
1993-07-20	US1993000093926

Abstract:

Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:
A₁ --A₂ --A₃ --A₄ --A₅ --A₆ --A₇ --A₈ --A₉ --A₁₀ --A₁₁ --A₁₂ --A₁₃ --A₁₄ --A₁₅ --A₁₆ --(A₁₇ --A₁₈₎ (1)

and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, which is either in the optionally --SH stablizied linear or in a cystine-bridged form

wherein each of A₁ and A₉ is independently a basic amino acid;

each of A₂ and A₃ is independently a small amino acid;

each of A₅, A₇, A₁₂, A₁₄ and A₁₆ is independently a hydrophobic amino acid;

A₄ is a basic or a small amino acid;

A₁₀ is a basic or a small amino acid or is proline;

A₁₁ is a basic or hydrophobic amino acid;

A₁₇ is not present or, if present, is a small amino acid;

A₁₈ is not present or, if present, is a basic amino acid; or a

modified form of formula (1) and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof wherein each of 1-4 cysteines is independently replaced by a hydrophobic amino acid or a small amino acid.

Attorney, Agent or Firm:

Pennie & Edmonds LLP ;

Primary / Asst. Examiners:

Achutamurthy, Ponnathapu; Moore, William W.

INPADOC Legal Status:

None Buy Now: Family Legal Status Report

Related Applications:

Go to Result Set: 3 patent(s) that list this one as related

Application Number	Filed	Patent	Pub. Date	Title
US1995000499523	1995-07-07		1998-09-08	Protegrins


	Parent Case:			This application is a continuation of application Ser. No. 08/499,523, filed Jul. 7, 1995, and issued as U.S. Pat. No. 5,804,558 on Sep. 8, 1998, which is a continuation-in-part of U.S. Ser. No. 08/451,832, filed May, 26, 1995, and now abandoned, which is a continuation-in-part of U.S. Ser. No. 08/243,879 filed May 17, 1994, and issued as U.S. Pat. No. 5,708,145 on Jan. 13, 1998, which is a continuation-in-part of U.S. Ser. No. 08/182,483 filed Jan. 13, 1994, and issued as U.S. Pat. No. 5,693,486 on Dec. 2, 1997, which is a continuation-in-part of U.S. Ser. No. 08/095,769 filed Jul. 26, 1993, and issued as U.S. Pat. No. 5,464,823 on Nov. 7, 1995, which is a continuation-in-part of U.S. Ser. No. 08/093,926 filed Jul. 20, 1993, and now abandoned. The contents of these applications are incorporated herein by reference.
	Designated Country:			AL AM AP AZ BB BG BR BY CN CZ EE GE HU IS KE KG KP KR KZ LK LR LS LT BE CH FR GB GR IE IT LI FI
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	First Claim: Show all 15 claims			What is claimed is: 1. A purified and isolated or recombinantly produced compound which has antimicrobial or antiviral activity and which has the formula A₁ --A₂ --A₃ --A₄ --A₅ --A₆ --A₇ --A₈ --A₉ --A₁₀ --A₁₁ --A₁₂ --A₁₃ --A₁₄ --A₁₅ --A₁₆ --A₁₇ --A₁₈ ( 1) or a pharmaceutically acceptable salt or an N-terminal acylated or a C-terminal amidated or esterified form thereof, which is either in a linear form or in a cystine-bridged form, wherein: each of A₁ and A₉ is independently a basic amino acid; each of A₂ and A₃ is independently a small amino acid; each of A₅, A₇, A₁₂, A₁₄ and A₁₆ is independently a hydrophobic amino acid; A₄ is a basic or a small amino acid; A₁₀ is a basic or a small amino acid or is proline; A₁₁ is a basic or a hydrophobic amino acid; A₁₇ is not present or, if present, is a small amino acid; A₁₈ is not present or, if present, is a basic amino acid; and each of C₆, C₈, C₁₃ and C₁₅ is independently selected from the group consisting of cysteine, a hydrophobic amino acid, a large polar amino acid and a small amino acid.
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	Forward References:			Show 8 U.S. patent(s) that reference this one

U.S. References:

Go to Result Set: All U.S. references | Forward references (8) | Backward references (22) | Citation Link

Patent	Pub.Date	Inventor	Assignee	Title
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US5458874	1995-10	Pereira et al.	Emory University	Method of increasing monocyte chemotaxis with CAP37 and monocyte chemotactic portions thereof
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Foreign References:

Publication	Date	IPC Code	Assignee	Title
EP0545730	1993-06	A01N 63/02	PIONEER HI-BRED INTERNATIONAL, INC.	Peptide with inhibitory activity towards plant pathogenic fungi
WO9100907	1991-01	A61K 38/00	EMORY UNIVERSITY	MONOCYTE CHEMOTACTIC PROTEINS AND RELATED PEPTIDES
WO9402589	1994-02	C12N 1/21	HIRATA MICHIMASA	MAMMALIAN CATIONIC PROTEINS HAVING LIPOPOLYSACCHARIDE BINDING AND ANTI-COAGULANT ACTIVITY
WO9428921	1994-12	A61K 37/02	DEMETER BIOTECHNOLOGIES, LTD.	METHOD OF TREATING PULMONARY DISEASE STATES WITH NON-NATURALLY OCCURRING AMPHIPATHIC PEPTIDES
WO9503325	1995-02	C07K 7/00	UNIVERSITY OF CALIFORNIA, LOS ANGELES	PROTEGRINS
WO9526747	1995-10	A01N 63/02	UNIVERSITY OF CALIFORNIA	PROPHENINS - ANTIBIOTIC PEPTIDES
WO9604373	1996-02	C07K 14/435	MAGAININ PHARMACEUTICALS, INC.	RECOMBINANT PRODUCTION OF BIOLOGICALLY ACTIVE PEPTIDES AND PROTEINS