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 Title: |
US6168779:
Methods and kits for identifying ductal orifices
[ Derwent Title ]
>> View Certificate of Correction for this publication
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| Country: |
US United States of America
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| Inventor: |
Barsky, Sanford H.; Los Angeles, CA
Love, Susan M.; Pacific Palisades, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2001-01-02
/ 1997-09-16
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| Application Number: |
US1997000931786
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| IPC Code: |
Advanced:
A61K 49/00;
Core:
more...
IPC-7:
A61B 8/00;
A61K 49/00;
A61M 1/00;
A61M 31/00;
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| ECLA Code: |
A61K49/00P4F8T; A61K49/00P4; A61K49/00P4F4C16F; A61K49/00P8;
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| U.S. Class: |
Current:
424/009.2;
424/009.1;
424/009.6;
424/009.8;
604/028;
604/104;
Original:
424/009.2;
424/009.1;
424/009.6;
424/009.8;
604/028;
604/054;
604/104;
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| Field of Search: |
424/9.2,9.6,9.8
436/172,808,183,807
435/975
128/898,630,654,653.5
604/028,54,104
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| Government Interest: |
The invention disclosed in this application was made with government support under U.S. Army Medical Research Grant Nos. DAMD17-94-J-4281 and DAMD17-96-C-6117. The government may have certain rights in the this invention.
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| Priority Number: |
| 1997-09-16 |
US1997000931786 |
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| Abstract: |
Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; E cadhedrin; and epithelial membrane antigen. Labelling of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.
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| Attorney, Agent or Firm: |
Gates & Cooper ;
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| Primary / Asst. Examiners: |
Housel, James C.; Devi, S.
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| Maintenance Status: |
CC Certificate of Correction issued
View Certificate of Correction
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Designated Country: |
AU BR CA EP IL JP MX
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| Family: |
Show 21 known family members
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First Claim:
Show all 27 claims |
What is claimed is:
1. A method for locating an orifice of a breast duct, said method comprising:
- labeling cellular material at the orifice with a detectable label coupled to an antibody specific for a tissue marker characteristic of the tissue at the ductal orifice; and
- locating the orifice based on the presence of said label at the orifice.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
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| Forward References: |
Show 14 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
DERABS C1999-243951
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| Other References: |
Pinkus et al. Am. J. Clin. Pathol. 85: 269-277, abstract, 1986.
(9 pages)
Cited by 3 patents
Sawaf et al. Pathol. Biol. (Paris) 40: 655-665, abstract, 1992.
(11 pages)
Cited by 2 patents
[ISI abstract]
Guelstein et al. Int. J. Cancer 42: 147-153, abstract, 1988.
(7 pages)
Cited by 3 patents
Jarasch et al. Human Pathol. 19: 276-289, abstract, 1988.
(14 pages)
Cited by 2 patents
Cardenose et al. AJR Am. J. Roentgenol. 162: 1081-1087, abstract, 1994.
(7 pages)
Cited by 2 patents
[ISI abstract]
Choudhury et al. Arch. Surg. 124: 874-875, abstract, 1989.
(2 pages)
Cited by 2 patents
Hou et al. Radiology 195: 568-569, abstract, 1995.
(2 pages)
Cited by 13 patents
[ISI abstract]
Sundstrom et al. Int. J. Biol. Markers 9: 102-108, abstract, 1994.
Allen et al. PNAS 81: 1203-1207, abstract, 1984.
Nagle et al. J. Histochem. Cytochem. 34: 869-881, abstract, 1986.
(13 pages)
Cited by 5 patents
Taylor-Papadimitriou et al. J. Cell. Sci. 94: 403-413, abstract, 1989.
Cited by 2 patents
Karesen et al. Tidsskr. Nor Laegeforen 113: 1233-1235, abstract, 1993.
Dairkee et al. J. Natl. Cancer Inst. 80: 691-695, abstract, 1988.
(5 pages)
Cited by 3 patents
Zimmer et al. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol. 49: 161-173, abstract, 1985.
(13 pages)
Cited by 2 patents
Stanec et al. Lijec Vjesn. 115: 17-20, abstract, 1993
Heatley et al. J. Clin. Pathol. 48: 26-32, abstract, 1995.
(7 pages)
Cited by 2 patents
[ISI abstract]
Barsky et al., "Pathologic analysis of breast duct endoscoped mastectomies" Laboratory Investigation, Modern Pathology, Annual Meeting Abstracts (1996) p. 15A, abstract No. 67.
Fabian et al., "Prevalence of abnormal biomarkers in fine needle breast aspirates in a high risk population: Potential for use in risk prediction" Proc. Ann. Meet. Am. Assoc. Cancer Res. (1993) 34:A1556.
Imayama et al., "Presence of elevated carcinoembryonic antigen on absorbent disks applied to nipple area of breast carcinoma patients" Cancer (1996) 78(6) :1229-1234.
(6 pages)
Cited by 7 patents
[ISI abstract]
Lewis, "Technique probes breast ducts for cancer cells" Biophotonics International (May/Jun. 1997) pp. 27-28.
Love, "Breast duct endoscopy: A pilot study of a potential technique for evaluating intraductal disease" 15th Annual San Antonio Breast Cancer Symposium, San Antonio, TX (1996) p. 180, abstract No. 197.
Love and Barsky, "Breast-duct endoscopy to study stages of cancerous breast disease" The Lancet (1996) 348:997-999.
(3 pages)
Cited by 17 patents
[ISI abstract]
Makita et al., "Duct endoscopy and endoscopic biopsy in the evaluation of nipple discharge" Breast Cancer Research and Treatment (1991) 18:179-187.
(9 pages)
Cited by 11 patents
[ISI abstract]
Okazaki et al., "Fiberoptic ductoscopy of the breast: A new diagnostic procedure for nipple discharge" Jpn. J. Clin. Oncol . (1991) 21(3) :188-193.
(6 pages)
Cited by 10 patents
[ISI abstract]
Petrakis, "Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid" Breast Cancer Research and Treatment (1986) 8:7-19.
(13 pages)
Cited by 17 patents
Petrakis, "Studies on the epidemiology and natural history of benign breast disease and breast cancer using nipple aspirate fluid" Cancer Epidemiology, Biomarkers & Prevention (Jan./Feb. 1993) 2:3-10.
(8 pages)
Cited by 11 patents
[ISI abstract]
Petrakis, "Nipple aspirate fluid in epidemiologic studies of breast disease", Epidemiologic Reviews (1993) 15:188-195.
(8 pages)
Cited by 19 patents
[ISI abstract]
Sartorius et al., "Contrast ductography for recognition and localization of benign and malignant breast lesions: An improved technique" Logan, W., ed., Breast Carcinoma, New York, Wiley, (1977) pp. 281-300.
Sartorius, "The Biochemistry of breast cyst fluids and duct secretions" Breast Cancer Research and Treatment (1995) 35:255-266.
(12 pages)
Cited by 9 patents
[ISI abstract]
Wrensch et al., "Breast fluid cholesterol and cholesterol β-epoxide concentrations in women with benign breast disease" Cancer Res. (1989) 49:2168-2174.
(7 pages)
Cited by 7 patents
Wrensch et al., "Factors associated with obtaining nipple aspirate fluid: Analysis of 1428 women and literature review" Breast Cancer Research and Treatment (1990) 15:39-51.
(13 pages)
Cited by 17 patents
Wrensch et al., "Breast cancer incidence in women with abnormal cytology in nipple aspirates of breast fluid" Am. J. Epidemiol. (1992) 135 (2) :130-141.
(12 pages)
Cited by 11 patents
[ISI abstract]
Falardeau, M. et al., "Selective galactophorectomy for mono-orificial nipple discharge without associated mass: technique and results. Apropos of seventy-three cases!" Ann. Chir. 45(9):796-801, 1991.
(6 pages)
Cited by 3 patents
[ISI abstract]
Feige, C., "Dynamic morpho-cyto-echography and the echographic galactoscopy endo-ductal sample. Intrinsic and extrinsic markers in the detection of breast cancers, " Ultrasound Med. Biol. 14:97-108, 1988.
(12 pages)
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(2 pages)
Cited by 13 patents
[ISI abstract]
Katamine, T. et al., "Determination of cancer-associated antigens in body fluid secreted from nipple," Chemical Abstracts, 114(9) (2 pages (Mar. 4, 1991). JP 02 280061A.
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| Continuity Data: |
| Application Number | Filed | Notes |
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US1997000931786 | 1997-09-16 | is a
related to the prior publication |
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US20020160431A1 issued 2002-10-31 Methods for performing medical procedures within a breast duct
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US1998000153564 | 1998-09-15 | is a
continuation in part of |
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US2000000740561
| 2000-12-19 |
(pending)
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US20010001059A1 issued 2001-05-10 Method and kit for obtaining fluids and cellular material from breast ducts
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>US1997000931786< | | is a
continuation in part of |
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US2000000740561
| 2000-12-19 |
(abandoned)
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US20010001059A1 issued 2001-05-10 Method and kit for obtaining fluids and cellular material from breast ducts
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US2002000175022 | 2002-06-19 | is a
continuation in part of |
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US1998000153564
| 1998-09-15 |
(pending)
[presumed granted]
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US6455027 issued 2002-09-24 Methods and kits for identifying ductal orifices in a nipple
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US2002000099439 | 2002-03-15 | is a
continuation in part of |
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US1998000153564
| 1998-09-15 |
(pending)
[presumed granted]
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US6455027 issued 2002-09-24 Methods and kits for identifying ductal orifices in a nipple
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|
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US2002000099439 | | is a
continuation in part of |
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US1998000153564
| 1998-09-15 |
|
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US6455027 issued 2002-09-24 Methods and kits for identifying ductal orifices in a nipple
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US2000000740561 | 2000-12-19 | is a
continuation of |
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US1998000067661
| 1998-04-28 |
(granted)
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US6221622 issued 2001-04-24 Method and kit for obtaining fluids and cellular material from breast ducts
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US2000000740561 | | is a
continuation of |
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US1998000067661
| 1998-04-28 |
|
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US6221622 issued 2001-04-24 Method and kit for obtaining fluids and cellular material from breast ducts
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|
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US1998000153564 | 1998-09-15 | is a
continuation in part of |
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>US1997000931786<
| 1997-09-16 |
(granted)
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US6168779 issued 2001-01-02 Methods and kits for identifying ductal orifices
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|
|
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US1998000153564 | | is a
continuation in part of |
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>US1997000931786<
| 1997-09-16 |
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US6168779 issued 2001-01-02 Methods and kits for identifying ductal orifices
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