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 Title: |
US6207159:
Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kaufman, Daniel L.; Santa Monica, CA
Tian, Jide; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2001-03-27
/ 1998-07-21
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| Application Number: |
US1998000119922
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| IPC Code: |
Advanced:
A61K 38/17;
A61K 39/00;
A61P 3/10;
A61P 37/06;
G01N 33/564;
G01N 33/68;
A61K 38/11;
Core:
A61P 3/00;
A61P 37/00;
A61K 38/10;
more...
IPC-7:
A01N 63/00;
A61K 38/28;
A61K 38/43;
A61K 39/00;
A61K 45/00;
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| ECLA Code: |
A61K38/17C; A61K39/00D4; G01N33/564; G01N33/68B; K61K38/11; S01N333/47A5; S01N800/04A; S01N800/24; S01N800/24A; S01N800/52;
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| U.S. Class: |
Current:
424/184.1;
424/093.7;
424/278.1;
424/283.1;
424/520;
424/556;
424/572;
424/810;
514/002;
514/003;
514/004;
514/021;
514/866;
530/351;
530/403;
Original:
424/184.1;
424/278.1;
424/283.1;
424/093.7;
424/520;
424/556;
424/572;
424/810;
514/002;
514/003;
514/004;
514/021;
514/866;
530/351;
530/403;
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| Field of Search: |
424/184.1,278.1,283.1,93.7,520,556,572,810
514/002,3,4,21,866
530/403,351
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| Government Interest: |
This invention was made with Government support under Grant No. DK48455, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
| 1998-07-21 |
US1998000119922 |
| 1997-07-09 |
US1997000890152 |
| 1996-11-29 |
US1996000758414 |
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| Abstract: |
Methods for detecting the status of an insulin-dependent diabetes mellitus (IDDM)-associated autoimmune response in a mammal are provided. Specifically, the ratio of the frequency of T helper 1 cells to T helper 2 cells specific for a pancreatic beta-cell associated antigen is indicative of the status of the autoimmune response. The methods may be employed prior to the onset of the clinical symptoms of the disease, thereby allowing identification of those at risk for developing clinical symptoms of IDDM, or subsequent to pancreatic tissue transplantation, for example, to measure the efficacy of treatment directed to enhancing the lifetime of the tissue transplant. Methods for prolonging the survival of tissue transplants are also provided. Specifically, a tissue-associated antigen is administered to the mammal which serves to shift the pathogenic Th1 response associated with pathological immunity toward a protective Th2 response.
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| Attorney, Agent or Firm: |
Flehr Hohbach Test Albritton & Herbert LLP ;
Lorenz, Todd A. ;
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| Primary / Asst. Examiners: |
Chan, Christina; VanderVegt, F. Pierre
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
This is a division of application U.S. Ser. No. 08/890,152 filed Jul. 9, 1997, now U.S. Pat. No. 6,022,697, which is a continuation-in-part of application Ser. No. 08/758,414 filed Nov. 29, 1996, abandoned.
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| Designated Country: |
AL AM AP AT AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE EP ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT
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| Family: |
Show 7 known family members
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First Claim:
Show all 18 claims |
What is claimed is:
1. A method for prolonging the survival of a pancreatic tissue transplant in a mammal, said method comprising:
- administering to said mammal a pancreatic tissue transplant protecting amount of a pancreatic β-cell-associated antigen, wherein said antigen administration results in an increase in the ratio of the number of T helper 2 cells specific for said antigen to the number of T helper 1 cells specific for said antigen.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 1 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 129(03)026988K
CHEMABS 132(11)136404M
DERABS C1998-322870
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| Other References: |
Rocken et al., Immunology Today 17(5):225-231 (1996).
Mosmann et al., Immunology Today 17(3):138-146 (1996).
Tisch et al., Nature 366:72-75 (1993).
Kaufman et al., Nature 366:69-72 (1993).
Petersen, JS et al. Autoimmunity. 25(3):129-138, Jun. 1997.*
Bieg, S et al. Diabetologia. 40(7):786-792, Jul. 1997.*
Chen, N et al. Transplantation. 60(11):1187-1193, Dec. 1995.*
Strom, TB et al. Curr. Opin. Immunol. 8(5):688-693, Oct. 1996.*
Nickerson, P et al. Curr. Opin. Immunol. 6(5):757-764, Oct. 1994.*
Tian, J et al. J. Exp. Med. 183:1561-1567, Apr. 1996.
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| Continuity Data: |
| Application Number | Filed | Notes |
|---|
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US2000000735422 | 2000-12-12 | is a
continuation of |
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>US1998000119922<
| 1998-07-21 |
(granted)
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US6207159 issued 2001-03-27 Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus
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>US1998000119922< | 1998-07-21 | is a
division of |
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US1997000890152
| 1997-07-09 |
(granted)
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US6022697 issued 2000-02-08 Methods for the diagnosis and treatment of insulin-dependent diabetes mellitus
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US1997000890152 | 1997-07-09 | is a
continuation in part of |
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US1996000758414
| 1996-11-29 |
(abandoned)
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