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Title: US6207412: Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells
[ Derwent Title ]


Country: US United States of America

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27 pages

 
Inventor: Weng, Zhigang; Los Angeles, CA
Witte, Owen N.; Sherman Oaks, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2001-03-27 / 1997-11-13

Application Number: US1997000969815

IPC Code: Advanced: C07K 14/705; C12N 15/12; A61K 38/00; A61K 39/00;
Core: C07K 14/435; more...
IPC-7: C12N 15/12; C12N 15/63;

ECLA Code: C07K14/705;

U.S. Class: Current: 435/069.1; 435/252.3; 435/320.1; 435/325; 536/023.1; 536/024.31;
Original: 435/069.1; 435/320.1; 435/325; 435/252.3; 435/172.3; 536/024.31; 536/023.1;

Field of Search: 536/23.5,23.1,24.31 435/69.1,172.3,252.3,320.1,325 530/350,300

Government Interest:

GOVERNMENT SUPPORT
    This invention was made with Government support under NIH grant number CA 53867. The Government has certain rights in the invention.

Priority Number:
1997-11-13  US1997000969815

Abstract: A G protein-coupled receptor (GPCR) which is activated by oncogenes. The receptor is found predominantly in hematopoietic cells and tissues and functions as a tumor suppressor gene and induces cell cycle arrest. This receptor may play an important role in regulating the proliferation and differentiation of hematopoietic cells. Regulation of receptor activity has several therapeutic applications.

Attorney, Agent or Firm: Gates & Cooper LLP ;

Primary / Asst. Examiners: Eyler, Yvonne; Basi, Nirmal S.

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Designated Country: AL AM AP AZ BA BB BG BR BY CA CN CU CZ EA EE GE GH GM HR HU ID IL IS JP KE  AT BE CH CY DE DK ES FI FR GB GR IE IT 

Family: Show 17 known family members

First Claim:
Show all 6 claims
What is claimed is:     1. An isolated polynucleotide having the nucleotide sequence shown in SEQ ID NO: 1 or 3.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 131(02)014841K DERABS C1999-338006

Other References:
  • Libert, F et al. Selective Amplification and Cloning of Four New Members of the G Protein-Coupled Receptor Family Science, vol. 244 pp. 569-572, 1989.*
  • Bouvier, M et al. Dynamic Palmitoylation of G-Protein-Coupled Receptors in Eukaryotic Cells. Methods in Enzymology, Academic Press, pp. 300-314, 1995.*
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  • Arvanitakis, et al., "Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation", Nature, 385 :347-350 (Jan. 23, 1997).
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  • Deng, et al.,"Identification of a major co-receptor for primary isolates of HIV-1", Nature, 381 :661-666 (Jun. 20, 1996).
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  • Doranz, et al., "A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors", Cell, 85 :1148-1158 (Jun. 28, 1996).
  • Dragic, et al., "HIV-1 entry in to CD4+ cells is mediated by the chemokine receptor CC-CRK-5", Nature, 381 :667-673 (Jun. 20, 1996).
  • Feng, et al., "HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor", Science, 272 :872-877 (May 10, 1996).
  • Forster, et al., "A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen", Cell, 87 :1037-1047 (Dec. 13, 1996).
  • Fu, M.L.X., "Characterization of anti-heart M2 muscarinic receptor antibodies--a combined clinical and experimentally study", Molecular and Cellular Biochemistry, 163/164 :343-347 (1996).
  • Goga, et al., "Alternative Signals to RAS for Hematopoietic Transformation by the BCR-ABL Oncogene", Cell, 82 :981-988 (Sep. 22, 1995).
  • Hubank, et al., "Identifying differences in mRNA expression by representational difference analysis of cDNA", Nucleic Acids Research, 22(25) :5640-5648 (1994).
  • Koshiba, et al., "Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes", Proc. Natl. Acad. Sci. USA, 94 :831-836 (Feb. 1997).
  • Kurzrock, et al., "The Molecular Genetics of Philadelphia Chromosome--Positive Leukemias", The New England Journal of Medicine, 319(15) :990-998 (Oct. 13, 1988).
  • Lugo, et al., "The BCR0ABL Oncogene Transform Rat-1 Cells and Cooperates with v-myc", Molecular and Cellular Biology, 9(3) :1263-1270 (Mar. 1989).
  • McLaughlin, et al., "Alternative Forms of the BCR-ARL Oncogene Have Quantitatively Different Potencies for Stimulation of Immature Lymphoid Cells", Molecular and Cellular Biology, 9(5) :1866-1874 (May 1989).
  • Muller, et al., "BCR Firs Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia Chromosome-Positive Human Leukemias", Molecular and Cellular Biology, 11(4) :1785-1792 (Apr. 1991).
  • Murphy, P.M., "The Molecular Biology of Leukocyte Chemoattractant Receptors", Annu. Rev. Immunol., 12 :593-633 (1994).
  • Pear, et al., "Production of high-titer helper-free retroviruses by transient transfection", Proc. Natl. Acad. Sci. USA, 90 :8392-8396 (Sep. 1993).
  • Pendergast, et al., "BCR-ABLl-Induced Oncogenesis Is Mediate by Direct Interaction with the SH2 Domain of the GRB-2 Adaptor Protein", Cell, 75 :175-185 (Oct. 8, 1993).
  • Schneider, et al., "Genes Specifically Expressed at Growth Arrest of Mammalian Cells", Cell, 54 :787-793 (Sep. 9, 1988).
  • Strader, et al., "The family of G-protein-coupled receptors", The FASEB Journal, 9 :745-754 (Jun. 1995).
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  • Tsukada, et al., "Deficient Expression of a B Cell Cytoplasmic Tyrosine Kinase in Human X-Linked Agammaglobulinemia", Cell, 72 :279-290 (Jan. 29, 1993).
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  • Continuity Data:
    Application Number Filed Notes

    US2001000796266 2001-02-28  is a continuation in part of
    US2000000553875  2000-04-20   (pending) [presumed granted]
         US6514696 issued 2003-02-04   Transcriptionally regulated G protein-coupled receptor G2A

    US2000000553875 2000-04-20  is a continuation in part of
    US1998000120025  1998-07-17   (granted)
         US6214562 issued 2001-04-10   Transcriptionally regualted G protein-coupled receptor

    US1998000120025 1998-07-17  is a continuation in part of
    >US1997000969815<  1997-11-13   (granted)
         US6207412 issued 2001-03-27   Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells


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