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Title: US6214562: Transcriptionally regualted G protein-coupled receptor
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Country: US United States of America

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43 pages

 
Inventor: Weng, Zhigang; Cambridge, MA
Witte, Owen N.; Sherman Oaks, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2001-04-10 / 1998-07-17

Application Number: US1998000120025
IPC Code: Advanced: C07K 14/705; C12N 15/12; A61K 38/00; A61K 39/00;
Core: C07K 14/435; more...
IPC-7: C12N 15/12; C12N 15/63; G01N 33/50;

ECLA Code: C07K14/705;

U.S. Class: Current: 435/007.1; 435/007.2; 435/007.21; 435/069.1; 435/252.3; 435/325; 435/456; 536/023.1; 536/024.3;
Original: 435/007.1; 435/007.2; 435/007.21; 435/069.1; 435/325; 435/172.3; 435/252.3; 536/024.3; 536/023.1;

Field of Search: 435/7.2,7.21,7.1,69.1,325,172.3,252.3 536/24.3,23.1 530/350,300

Government Interest:

GOVERNMENT SUPPORT
    This invention was made with Government support under NIH Grant No. CA 53867. The Government has certain rights in the invention.

Priority Number:
1998-07-17  US1998000120025

Abstract:     A G protein-coupled receptor (GPCR), called G2A, whose expression is regulated and functions at the G2/M checkpoint to ensure properly controlled duplication of hematopoietic cells. The receptor is found predominantly in hematopoietic cells and tissues and functions as a tumor suppressor gene and induces cell cycle arrest. This receptor may play an important role in regulating the proliferation and differentiation of hematopoietic cells. Regulation of receptor activity has several therapeutic applications.

Attorney, Agent or Firm: Gates & Cooper LLP ;

Primary / Asst. Examiners: Eyler, Yvonne; Basi, Nirmal S.
Maintenance Status: CC Certificate of Correction issued
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Related Applications: Go to Result Set: 4 patent(s) that list this one as related
Application Number Filed Patent Pub. Date  Title
US1997000969815 1997-11-13       


       
Parent Case:

RELATED APPLICATIONS
    This present application is a continuation-in-part of U.S. patent application Ser. No. 08/969,815, filed on Nov. 13, 1997.

Designated Country: AL AM AP AZ BA BB BG BR BY CN CU CZ EA EE GE GH GM HR HU ID IL IS KE  AT BE CH CY DE DK ES FI FR GB GR IE IT 

Family: Show 17 known family members
First Claim:
Show all 12 claims		 What is claimed is:     1. A method of identifying a compound which specifically binds a G protein coupled receptor G2A, wherein said G2A comprises a protein which can be expressed by a polynucleotide selected from the group consisting of SEQ ID NOS: 1 and 3, comprising the steps of:
  • (a) contacting said G2A receptor with a test compound; and
  • (b) determining whether said test compound binds to said G2A receptor
wherein said test compound which binds said receptor may be further screened for activation of said receptor.

Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 131(02)014841K CHEMABS 134(20)275755F CHEMABS 134(20)275755F CHEMABS 136(22)337370D DERABS C1999-338006

Other References:
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    • Continuity Data:
    Application Number Filed Notes
    US2001000796266 2001-02-28  is a continuation in part of
    US2000000553875  2000-04-20   (pending) [presumed granted]
         US6514696 issued 2003-02-04   Transcriptionally regulated G protein-coupled receptor G2A
    US2000000553875 2000-04-20  is a continuation in part of
    >US1998000120025<  1998-07-17   (granted)
         US6214562 issued 2001-04-10   Transcriptionally regualted G protein-coupled receptor
    >US1998000120025< 1998-07-17  is a continuation in part of
    US1997000969815  1997-11-13   (granted)
         US6207412 issued 2001-03-27   Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells


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