 |
|
|
|
|
|
 Title: |
US6231857:
Antibodies to S. mutans and uses thereof
[ Derwent Title ]
|
| Country: |
US United States of America
|
| |
| Inventor: |
Shi, Wenyuan; Los Angeles, CA
Hume, Wyatt R.; Los Angeles, CA
|
| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
News, Profiles, Stocks and More about this company
|
| Published / Filed: |
2001-05-15
/ 1999-08-20
|
| Application Number: |
US1999000378247
|
| IPC Code: |
Advanced:
C07K 16/12;
Core:
more...
IPC-7:
A61K 39/40;
|
| ECLA Code: |
C07K16/12B12;
|
| U.S. Class: |
Current:
424/165.1;
424/130.1;
424/141.1;
435/243;
435/325;
435/326;
435/332;
435/354;
530/388.1;
530/388.2;
530/388.4;
Original:
424/165.1;
424/130.1;
424/141.1;
530/388.1;
530/388.4;
530/388.2;
435/243;
435/325;
435/326;
435/332;
435/354;
|
| Field of Search: |
530/350,387.1,388.1,388.4,388.2
435/243,325,326,332,354
424/244.1,130.1,141.1,165.1
|
| Priority Number: |
| 1999-08-20 |
US1999000378247 |
| 1998-09-28 |
US1998000102179P |
|
| Abstract: |
The invention describes three monoclonal IgG antibodies, referred to as SWLA1, SWLA2, and SWLA3, which appear to recognize a species-specific lipooligosaccharide or lipopolysaccharide on the cell surface of S. mutans. The invention also describes a rapid method of detection of S. mutans without the need for prior growth of the bacteria in culture. The invention further describes a methods of utilizing these antibodies for rapidly quantitatively detecting S. mutans. These methods are sensitive enough to detect the presence of a single S. mutans bacterial cell. These methods can be widely used in the clinical diagnosis and treatment of dental caries in humans.
|
| Attorney, Agent or Firm: |
Oppenheimer, Wolff & Donnelly LLP ;
|
| Primary / Asst. Examiners: |
Graser, Jennifer;
|
| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
|
| Parent Case: |
CROSS-REFERENCES
This application claims priority from a U.S. provisional application, U.S. application Ser. No. 60/102,179, filed Sep. 28, 1998.
|
| Designated Country: |
AE AL AM AP AZ BA BB BG BR BY CA CN CR CU CZ DM EA EE GD GE GH GM HR HU ID IL AT BE CH CY DE DK ES FI FR GB GR IE
|
| Family: |
Show 7 known family members
|
First Claim:
Show all 6 claims |
What is claimed is:
1. A monoclonal antibody that specifically binds an antigen on the surface of Streptococcus mutans and which is the monoclonal antibody produced by a hybridoma deposited with the American Type Culture Collection as ATCC No. HB12559, and which is designated SWLA1.
|
| Background / Summary: |
Show background / summary
|
| Drawing Descriptions: |
Show drawing descriptions
|
| Description: |
Show description
|
| Forward References: |
Show 1 U.S. patent(s) that reference this one
|
|
|
|
|
|
|
| Foreign References: |
None
|
| Other Abstract Info: |
CHEMABS 132(15)193263P
DERABS C2000-224664
|
| Other References: |
Shi, Jewett, and Hume; Rapid and Quantitative Detection of Streptococcus Mutans with Species-Specific Monoclonal Antibodies; Aug. 8, 1998; pp. 365-371.
Soet, van Dalen, and de Graaff; Identification of Mutans Streptococci with Monoclonal Antibodies; 1990; pp. 219-225.
De Soet, Holbrook, Magnusdottir, and De Graaff; Streptococcus Sobrinus and Streptococcus Mutans in a Longitudinal Study of Dental Caries; 1993; pp. 237-243.
Akiyama; Monoclonal Antibodies Specific for a Polysaccharide Antigenic Determinant of Streptococcus Mutans; 1995; pp. 360-372.
Database WPI; Monoclonal Antibody Specific Streptococcus Mutans Preparation Isolate Antibody Produce Cell Mouse Immune Mouse Myeloma Cell; Derwent Publications Ltd; Jul. 10, 1990; Week 9033.
Database WPI; Monoclonal Antibody Specific Streptococcus Mutans Preparation Isolate Antibody Produce Cell Mouse Immune Antigen Fuse Mouse Myeloma Cell; Derwent Publications Ltd; Jul. 10, 1990; Week 9033.
Database WPI; Monoclonal Antibody Oral Composition B ase Diagnose Investigate Respond Streptococcus Mutans Prevent Caries; Derwent Publications Ltd; Jul. 10, 1990; Week 9816.
Gazi; Monoclonal Antibodies in Dentistry; British Dental Journal; Dec. 6, 1986; vol. 161, No. 11; pp. 399-405.
Van Raamsdonk, de Soet, Bosch-Tijhof; and de Graaff; Oral Microbiology and Immunology; Effect of Antibodies on Chemiluminescencce and on Killing of Streptococcus Sobrinus by Polymorphonuclear Leukocytes; vol. 11, No. 4, Aug. 1996; pp. 254-258.
Van Raamsdonk, de Soet, and de Graaff; Caries Research; Effect of Monoclonal Antibodies on the Colonization of rats by Streptococcus Sobrinus; Jan. 27, 1993; pp. 27: 31-37.
Lehner, Ma, and Kelly; Genetically Engineered Vaccines; Advances in Experimental Medicine and Biology; vol. 327; A Mechanism of Passive Immunization with Monoclonal Antibodies to a 185,000Mr Streptococcal Antigen; 1992; pp. 151-163.
Ma, Hikmat, Wycoff, Vine, Chargelegue, Yu, Hein, and Lehner; Nature Medicine; vol. 4, No. 5; May 1998; Characterization of a Recombinant Plant Monoclonal Secretory Antibody and Preventive Immunotherapy in Humans; p. 601-606.
Ma, Smith, and Lehner; Use of Monoclonal Antibodies in Local Passive Immunization to Prevent Colonization of Human Teeth by Streptococcus Mutans; Infection and Immunity, May 1987, vol. 55, No. 5; pp. 1274-1278.
Everhart, Mallett and Doyle; Microbiological Sciences, Dental Caries Vaccine: Some Problems Solved; vol. 2, No. 10; 1985; pp. 312-313.
Ma, Hunjan, Smith, Kelly, and Lehner; Infection and Immunity; An Investigation into the Mechanism of Protection by Local Passive Immunization with Monoclonal Antibodies Against Streptococcus Mutans; Oct. 1990; vol. 58, No. 10; pp. 3407-3414.
Kobayashi, Izumi, Okamura, Matsui, Ishibashi, and Sakai; Caries Research; Biological Behavior of Human Dental Pulp Cells in Response to Carious Stimuli Analyzed by PCNA Immunostaining and AgNOR Staining; May-Jun. 1996; pp. 225-230.
Arakawa and Langridge; Nature Medicine; Plants are not Just Passive Creatures; vol. 4, No. 5, May 1998, pp. 550-551.
Lehner, Caldwell, and Smith; Infection and Immunity; Local Passive Immunization by Monoclonal Antibodies Against Streptococcal Antigen I/II in the Prevention of Dental Caries; Dec. 1985, vol. 50, No. 3, pp. 796-799.
Shi, Jewett, and Hume; Hybridoma; Rapid and Quantitative Detection of Streptococcus Mutans with Species-Specific Monoclonal Antibodies; vol. 17, No. 4, 1998; pp. 365-371.
|
|
 Nominate this for the Gallery...
|
|
