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 Title: |
US6262254:
8-fluoropurine compounds
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Barrio, Jorge R.; Agoura Hills, CA
Satyamurthy, Nagichettiar; Los Angeles, CA
Namavari, Mohammad; Los Angeles, CA
Phelps, Michael E.; Encino, CA
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| Assignee: |
The Regents of Univ. of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2001-07-17
/ 1998-11-25
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| Application Number: |
US1998000199975
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| IPC Code: |
Advanced:
C07D 473/00;
Core:
more...
IPC-7:
C07D 473/00;
C07H 19/167;
C07H 19/173;
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| ECLA Code: |
C07D473/00; M07D473/00;
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| U.S. Class: |
Current:
536/027.11;
536/027.6;
536/027.8;
536/027.81;
544/264;
Original:
536/027.11;
536/027.6;
536/027.8;
536/027.81;
544/264;
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| Field of Search: |
536/27.11,27.6,27.8,27.81
544/264
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| Government Interest: |
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT
This invention was made with government support under Grant No. DE-FC0387-ER60615, awarded by the Department of Energy. The government has certain rights in the invention.
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| Priority Number: |
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| Abstract: |
An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F2 in He or other inert gas.
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| Attorney, Agent or Firm: |
Christie, Parker & Hale, LLP ;
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| Primary / Asst. Examiners: |
Geist, Gary; Crane, L. Eric
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
CROSS REFERENCE TO RELATED APPLICATION
This application is a continuation of U.S. application Ser. No. 08/846,424, filed Apr. 30, 1997, now U.S. Pat. No. 5,861,503.
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| Family: |
Show 2 known family members
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First Claim:
Show all 12 claims |
What is claimed is:
1. An 8-fluoropurine compound of the formula: [Figure]
where X is alkyl, aryl, arylalkyl, alkoxy, aryloxy, acetylamino, amino, carbamoyl, alkoxyamino, aryloxyamino, alkylcarbonylamino, alkoxyacetylamino, aryloxyacetylamino, benzoylamino, tritylamino, halogen, or hydrogen,
- Y is alkyl, aryl, arylalkyl, alkoxy, aryloxy, acetyl, amino, secondary amino, tertiary amino, protected amino, carbamoyl, alkoxyamino, aryloxyamino, alkylcarbonylamino, alkoxyacetylamine, aryloxyacetylamino, benzoylamino, tritylamino, halogen, hydroxy, or hydrogen,
- R is alkyl, aryl, arylalkyl, hydrogen, hydroxyalkoxy lower alkyl, or protected hydroxyalkoxy lower alkyl,
- where each alkyl or aryl moiety independently is unsubstituted or substituted with one or more of hydroxy, halogen, lower alkyl or lower alkoxy;
- and provided that when X is hydrogen and Y is hydrogen, R is not methyl; and tautomers thereof.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 6 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 130(07)081795R
DERABS C1999-130435
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| Other References: |
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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