Work Files Saved Searches
   My Account                                                  Search:   Quick/Number   Boolean   Advanced   Derwent    Help   


 The Delphion Integrated View
  Buy Now:   Buy PDF- 14pp  PDF  |   File History  |   Other choices   
  Tools:  Citation Link  |  Add to Work File:    
  View:  Expand Details   |  INPADOC   |  Jump to: 
  Go to:  Derwent  
 Email this to a friend  Email this to a friend 
       
Title: US6280941: Genetic marker test for lupus
[ Derwent Title ]

Country: US United States of America

View Images High
Resolution

 Low
 Resolution

 
14 pages

 
Inventor: Tsao, Betty P.; Los Angeles, CA
Cantor, Rita M.; Rolling Hills Estates, CA
Rotter, Jerome I.; Los Angeles, CA

Assignee: Cedars-Sinai Medical Center, Los Angeles, CA
The Regents of the University of California, Oakland, CA
other patents from CEDARS SINAI MEDICAL CENTER (93770) (approx. 136)
 News, Profiles, Stocks and More about this company

Published / Filed: 2001-08-28 / 1999-03-29

Application Number: US1999000280181
IPC Code: Advanced: C07H 21/04; C12P 19/34; C12Q 1/68;
Core: C07H 21/00; C12P 19/00; more...
IPC-7: C07H 21/04; C12P 19/34; C12Q 1/68;

U.S. Class: Current: 435/006; 435/091.2; 435/810; 536/023.2; 536/024.31; 536/024.33;
Original: 435/006; 435/091.2; 435/810; 536/023.2; 536/024.31; 536/024.33;

Field of Search: 435/006,15,91.2,194,810 536/23.2,24.31,24.33

Priority Number:
1999-03-29  US1999000280181

Abstract:     Disclosed is a genetic testing method for diagnosing systemic lupus erythematosus (SLE) in a human subject. The method is related to amplifying nucleic acids from human tissue samples and analyzing for a variant allele of a gene encoding poly(ADP-ribosyl)transferase expression (PARP), which is diagnostic of SLE or indicates a genetic predisposition for developing SLE. Also disclosed are useful oligonucleotide primers, primer sets and genetic testing kits for detecting a genetic predisposition for developing SLE.

Attorney, Agent or Firm: Sidley Austin Brown & Wood ;

Primary / Asst. Examiners: Jones, W. Gary; Johannsen, Diana
Maintenance Status: E2 Expired  Check current status

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

Designated Country: AE AG AL AM AP AT AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP 

Family: Show 13 known family members
First Claim:
Show all 7 claims		 We claim:     1. A method of detecting a genetic predisposition in a human subject to develop systemic lupus erythematosus (SLE), comprising:
  • a) collecting a tissue sample from a human subject;
  • b) amplifying nucleic acids from said tissue sample using a forward primer having nucleotide sequence GAT TCC CCA TCT CTC TTT CTT T (SEQ. ID. NO. 1) and a reverse primer having nucleotide sequence AAA TTG TGG TAA TGA CTG CA (SEQ ID. NO. 2) to obtain amplification products, said nucleic acids comprising a genomic sequence of human chromosome lq41-q42 between microsatellite markers D1S2860 and D1S213; and
  • c) detecting in the amplification products the presence or absence of a fragment of 85-base pair length, the presence of said fragment of 85-base pair length indicating a genetic predisposition in said subject to develop SLE.
    •


Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 7 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (7)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 133(21)291911P DERABS C2000-647245

Other References:
  • Alkhatib, H.M. et al., "Cloning and expression of cDNA for human poly(ADP-ribose) polymerase", Proc. Natl. Acad. Sci. USA, 84: 1224-1228, Mar. 1987. (5 pages) Cited by 7 patents
  • Cherney, B.W., et al., "cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase", Proc. Natl. Acad. Sci. USA, 84: 8370-8374, Dec. 1987. (5 pages) Cited by 13 patents
  • Dib, C. et al., "A comprehensive genetic map of the human genome based on 5,264 microsatelllites", Nature, 380: 152-154, Mar. 14, 1996. (3 pages) Cited by 31 patents [ISI abstract]
  • Suzuki, H. et al., "Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation", Biochemical and Biophysical Research Communications, 146(2): 403-409, Jul. 31, 1987. (7 pages) Cited by 6 patents
  • Kotzin, B.L., "Systemtic Lupus Erythematosus", Cell, 85: 303-306, May 3, 1996. (4 pages) Cited by 2 patents [ISI abstract]
  • Ogura, T. et al., "Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase β gene", Biochemical and Biophysical Research Communications, 167(2): 701-710, Mar. 16, 1990. (10 pages) Cited by 2 patents
  • Trucco, C. et al., "Mutations in the amino-terminal domain of the human poly(ADP-ribose) polymerase that affect its catalytic activity but not its DNA binding capacity", FEBS Letters, 399: 313-316 (1996). (4 pages) Cited by 2 patents [ISI abstract]
  • Yokoyama, Y. et al., "Human poly(ADP-ribose) polymerase gene", Eur. J. Biochem., 194: 521-526 (1990). (6 pages) Cited by 2 patents
  • Abe, M., et al., "In vitro spontaneous and UVB-induced lymphocyte apoptosis are not specific to SLE", Photodermatol. Photoimmunol. Photomed., 13(5-6): 204-207, Oct.-Dec. 1997. (4 pages) Cited by 2 patents [ISI abstract]
  • Auer, B. et al., "Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene", DNA 8(8): 575-80, Oct. 1989, Abstract only. (6 pages) Cited by 4 patents
  • Calvo-Alen, J. et al., "Identification of patient subsets among those presumptively diagnosed with, referred, and/or followed up for systemic lupus erythematosus at a large tertiary care center", Arthritis Rheum. , 38(10): 1475-84, Oct. 1995, Abstract only. (10 pages) Cited by 2 patents [ISI abstract]
  • Casciola-Rosen, L., et al., "Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE", Lupus, 6(2): 175-80, 1997. (6 pages) Cited by 7 patents [ISI abstract]
  • Davidson, A., et al., "Diagnosing and Treating the Predominantly Female Problems of Systematic Autoimmune Diseases", Medscape Womens Health, 2(2): 6, Feb. 1997, Abstract only.
  • Engelstein, M., et al., "A PCR-based linkage map of human chromosome 1", Genomics, 15(2): 251-8, Feb. 1993, Abstract only. (8 pages) Cited by 3 patents [ISI abstract]
  • Hasan, T., et al., "Photosensitivity in lupus erythematosus, UV photoprovocation results compared with history of photosensitivity and clinical findings", Br. J. Dermatol., 136(5); 699-705, May 1997, Abstract only. (7 pages) Cited by 2 patents [ISI abstract]
  • Herzog, H. et al., "Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli", Proc. Natl. Acad. Sci. USA, 86(10): 3514-8, May 1989, Abstract only. (5 pages) Cited by 3 patents
  • Karlson, E.W., et al., "The relationship of socioeconomic status, race, and modifiable risk factors to outcomes in patients with systemic lupus erythematosus", Arthritis Rheum., 40(1): 47-56, Jan. 1997. (10 pages) Cited by 2 patents [ISI abstract]
  • Korb, L.C., et al., "C1q binds directly and specifically to suface blebs of apoptotic human keratinocytes: complements deficiency and systemic lupus erythematosus revisited", J. Immunol., 158(10): 4525-8, May 15, 1997, Abstract only. (4 pages) Cited by 2 patents [ISI abstract]
  • Krause, I., et al., "Seasons of the year and activity of SLE and Behcet's disease", Scand. J. Rheumatol., 26(6): 435-9, (1997), Abstract only. (5 pages) Cited by 2 patents [ISI abstract]
  • Kupper, J.H., et al., "Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) by immunocytochemistry", Histochem. J., 28(5): 391-5, May 1996, Abstract only. (5 pages) Cited by 3 patents [ISI abstract]
  • Minami, Y., et al., "Female systemtic lupus erythematosus in Miyagi Prefecture, Japan: a case-control study of dietary and reproductive factors", Tohoku J. Exp. Med., 169(3): 245-52, Mar. 1993, Abstract only. (8 pages) Cited by 2 patents [ISI abstract]
  • Nyberg, F. et al., "Early detection of epidermal dust-like particles in experimentally UV-induced lesions in patients with photosensitivity and lupus erythematosus", Acta. Derm. Venereol., 78(3): 177-9, May 1998, Abstract only. (3 pages) Cited by 2 patents [ISI abstract]
  • Sanchez-Guerrero, J. et al., "Utility of anti-SM, anti-RNP, anti-Ro/SS-A, and anti-La/SS-B (extractable nuclear antigens) detected by enzyme-linked immunosorbent assay for the diagnosis of systemic lupus erythematosus", Arthritis Rheum., 39(6): 1055-61, Jun. 1996, Abstract only. (7 pages) Cited by 2 patents [ISI abstract]
  • Slater, C.A., et al., "Antinuclear antibody testing. A study of clinical utility", Arch. Intern. Med., 156(13): 1421-5, Jul. 8, 1996, Abstract only. (5 pages) Cited by 2 patents [ISI abstract]
  • Rood, M.J., et al., "Female sex hormones at the onset of systemic lupus erythematosus affect survival", Br. J. Rheumatol., 37(9): 1008-10, Sep. 1998, Abstract only. (3 pages) Cited by 2 patents [ISI abstract]
  • Rozzo, S. J., et al., "Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice", J. Immunol., 162(5): 2623-30, Mar. 1, 1999, Abstract only. (8 pages) Cited by 2 patents [ISI abstract]
  • Sequeira, J.F., et al., "Systemic lupus erythematosus: sex hormones in male patients", Lupus, 2(5): 315-7, Oct. 1993, Abstract only. (3 pages) Cited by 2 patents [ISI abstract]
  • Vyse, T.J., et al., "Genetic basis of systemic lupus erythematosus", Curr. Opin. Immunol., 8(6): 843-51, Dec. 1996, Abstract only. (9 pages) Cited by 2 patents [ISI abstract]
  • Vyse, T.J., et al., "Genetic susceptibility to systemic lupus erythematosus", Annu. Rev. Immunol., 16:261-92, 1998. (32 pages) Cited by 2 patents [ISI abstract]
  • Vyse, T.J., et al., "Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice", J. Immunol., 158(11): 5566-74, Jun. 1, 1997, Abstract only. (9 pages) Cited by 2 patents [ISI abstract]
  • Vyse, T.J., et al., "Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice", J. Immunol., 160(6): 2757-66, Mar. 15, 1998, Abstract only. (10 pages) Cited by 2 patents [ISI abstract]
  • Yoshida, S. et al., "Interaction of poly(ADP-ribose) polymerase with DNA polymerase alpha", Mol. Cell. Biochem., 138(1-2): 39-44, Sep. 1994, Abstract only. (6 pages) Cited by 2 patents [ISI abstract]
  • Maugh II, T.H., "Team of Researchers Narrows Search for Cause of Lupus", Metro News, Los Angeles Times, B-8, Wednesday, Feb. 19, 1997.
  • Tsao, B.P., et al., "Evidence for linkage of a candidate chromosome 1 region to systemic lupus erythematosus (SLE)", Arthritis & Rheum., 39: S217, 1996, Abstract only.
  • Tsao, B.P., et al., "The genetic basis of systemic lupus erythematosus", Proc. Assoc. Am. Physicians, 110(2): 113-7, Mar.-Apr. 1998. (5 pages) Cited by 2 patents [ISI abstract]
  • Tsao, B.P., et al., "Genetic susceptibility to lupus nephritis", Lupus, 7(9): 585-90, 1998. (6 pages) Cited by 3 patents [ISI abstract]
  • Tsao, B.P., et al., "PARP alleles within the linked chormosomal region are associated with systemic lupus erythematosus", J. Clin. Invest., 103(8): 1135-40, Apr. 1999. (6 pages) Cited by 2 patents [ISI abstract]
  • Tsao, B.P., et al., "Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus", J. Clin. Invest., 99(4): 725-731, Feb. 1997. (7 pages) Cited by 4 patents [ISI abstract]
  • Oliver, F. J., et al., "DNA Repair '99 Poly(ADP-Ribose) Polymerase in the Cellular Response to DNA Damage, Apoptosis, and Disease", Am. J. Hum. Genet., 64: 1282-1288. 1999. (7 pages) Cited by 2 patents [ISI abstract]
  • Moser, K.L., et al., "Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q African-American pedigrees", Proc. Natl. Acad. Sci. USA, 95: 14869-14874, Dec. 1998. (6 pages) Cited by 2 patents [ISI abstract]
  • Gaffney, P.M., et al., "A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families", Proc. Natl. Acad. Sci. USA, 95: 14875-14879, Dec. 1998. (5 pages) Cited by 2 patents [ISI abstract]
  • Sibley, J.T., et al., "Altered metabolism of poly(ADP-ribose) in the peripheral blood lymphocytes of patients with systemic lupus erythematosus", Arthritis and Rheumatism, 32(8): 1045-1049, Aug. 1989. (5 pages) Cited by 2 patents
  • Haug, B.L., et al., "Altered Poly(ADP-Ribose) Metabolism in Family Members of Patients with Systemic Lupus Erythematosus", J. Rheumatol., 21: 851-56, 1994. (6 pages) Cited by 2 patents [ISI abstract]
  • Lee, J.S., et al., "Decreased mRNA Levels Coding for Poly(ADP-Ribose) Polymerase in Lymphocytes of Patients with SLE", Lupus, 3:113-116, 1994. (4 pages) Cited by 2 patents [ISI abstract]
  • Loetscher, P., et al., "Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells", Proc. Natl. Acad. Sci. USA, 84(5): 1286-9, Mar. 1987, Abstract only. (4 pages) Cited by 2 patents
  • Hirose, S., et al., "Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW) F1 mice", Int. Immunol., 6(12): 1857-64, Dec. 1994, Abstract only. (8 pages) Cited by 2 patents [ISI abstract]
  • Morel, L. et al., "Multiplex inheritance of component phenotypes in a murine model of lupus", Mamm. Genome, 10(2): 176-81, Feb. 1999, Abstract only. (6 pages) Cited by 2 patents [ISI abstract]
  • Morel, L. et al., "Polygenic control of susceptibility to murine systemic lupus erythematosus", Immunity, 1(3): 219-29, Jun. 1994, Abstract only. (11 pages) Cited by 5 patents [ISI abstract]
  • Cornillet, P. et al., "Increased freqency of the long (S) allotype of CR1 (the C3b/C4b receptor, CD35) in patients with systemic lupus erythematosus", Clin. Exp. Immunol., 89(1): 22-5, Jul. 1992, Abstract only. (4 pages) Cited by 2 patents [ISI abstract]
  • Kumar, A. et al., "Hind III, genomic polymorphism of the C3b receptor (CR1) in patients with SLE: low erythrocyte CR1 expression is an acquired phenomenon", Immunol. Cell Biol., 73(5): 457-62, Oct. 1995, Abstract only. (6 pages) Cited by 3 patents [ISI abstract]
  • Deguchi, Y. et al., "A human homeobox gene, HB24, inhibits development of CD4+ T cells and impairs thymic involution in transgenic mice", J. Biol. Chem., 268(5): 3646-53, Feb. 15, 1993, Abstract only. (8 pages) Cited by 2 patents [ISI abstract]
  • Raz, E. et al., "Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery", Lupus, 4(4): 286-92, Aug. 1995, Abstract only. (7 pages) Cited by 4 patents [ISI abstract]
  • Slater, C.A. et al., "Antinuclear antibody testing. A study of clinical utility." Arch Intern. Med., 156(13): 1421-5, Jul. 8, 1996, Abstract only. (5 pages) Cited by 2 patents [ISI abstract]
  • Suarez-Almazor, M.E. et al., "Utilization and predictive value of laboratory tests in patients referred to rheumatologists by primary care physicians", J. Rheumatol., 25(10); 1980-5, Oct. 1998. (6 pages) Cited by 2 patents [ISI abstract]
  • Tan, E.M. et al., "The 1982 revised criteria for the classification of systemic lupus erythematosus", Arthritis Rheum., 25(11): 1271-7, Nov. 1982, Abstract only. (7 pages) Cited by 13 patents
  • Watson, M.L. et al., "Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci", J. Exp. Med., 176(6): 1645-56, Dec. 1, 1992, Abstract only. (12 pages) Cited by 2 patents [ISI abstract]
  • Kono, D.H. et al. "Lupus susceptibility loci in New Zealand Mice", Proc. Natl. Acad. Sci. USA, 91(21):10168-72, Oct. 11, 1994, Abstract only. (5 pages) Cited by 4 patents [ISI abstract]
  • Drake, C.G. et al., "Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW) F1 mice", Proc. Natl. Acad. Sci. USA, 91(9): 4062-6, Apr. 26, 1994, Abstract only. (5 pages) Cited by 3 patents [ISI abstract]
  • Kuokkanen S., "A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2", Nat. Genet., 13(4): 477-80, Aug. 1996, Abstract only. (4 pages) Cited by 2 patents [ISI abstract]
  • Botto, M. et al., "Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies", Nat. Genet., 19(1): 56-9, May 1998, Abstract only. (4 pages) Cited by 2 patents [ISI abstract]
  • Bowness, P. et al., "Hereditary C1q deficiency and systemic lupus erythematosus", QJM, 87(8): 455-64, Aug. 1994, Abstract only. (10 pages) Cited by 2 patents [ISI abstract]
  • Botto, M. et al., "Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease", Clin. Exp. Immunol., 104(2): 264-8, May. 1996, Abstract only.
  • Botto, M., "C1q knock-out mice for the study of complement deficiency in autoimmune disease", Exp. Clin. Immunogenet., 15(4): 231-4, 1998, Abstract only. (4 pages) Cited by 2 patents [ISI abstract]
  • Tsao, B.P. et al., "ADPRT alleles from the chromosome 1q41-q42 linked region are associated with SLE", Arthritis & Rheum., 41:580, 1998, Abstract only
  • Fougerousse, F. et al. Nucleic Acids Res. 20(5):1116 1992.*
  • Ahern, H. The Scientist 9(15):20, Jul. 1995.* Cited by 26 patents [ISI abstract]
  • Murray, J. et al. GenEmbl Accession No. G08223, Feb. 1997.*
  • Doggett, N.A. et al. Genomics 18:687-689, 1992.*
  • Delrieu, O. et al. Arthritis & Rheumatism 42(10):2197-2197, Oct. 1999.


    • Continuity Data:
    Application Number Filed Notes
    US1999000280181 1999-03-29  is a related to the prior publication
         US20040152075A1 issued 2004-08-05  Genetic marker test for lupus
    US2001000909317 2001-07-18  is a continuation in part of
    >US1999000280181<  1999-03-29   (granted)
         US6280941 issued 2001-08-28   Genetic marker test for lupus
    US2001000909317   is a continuation in part of
    >US1999000280181<  1999-03-29
         US6280941 issued 2001-08-28   Genetic marker test for lupus


    Inquire Regarding Licensing

    Powered by Verity
    Plaques from Patent Awards      Gallery of Obscure PatentsNominate this for the Gallery...

    Thomson Reuters Copyright © 1997-2010 Thomson Reuters 
    Subscriptions  |  Web Seminars  |  Privacy  |  Terms & Conditions  |  Site Map  |  Contact Us  |  Help