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Title: US6284731: Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
[ Derwent Title ]

Country: US United States of America

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75 pages

 
Inventor: Maccecchini, Maria-Luisa; West Chester, PA

Assignee: Bearsden Bio, Inc., Aston, PA
other patents from BEARSDEN BIO, INC. (739031) (approx. 8)
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Published / Filed: 2001-09-04 / 1998-09-03

Application Number: US1998000146268
IPC Code: Advanced: C07K 14/435; A61K 38/00;
Core: more...
IPC-7: A61K 38/08; A61K 38/10; C07K 7/00;

ECLA Code: C07K14/435;

U.S. Class: Current: 514/013; 514/014; 514/015; 530/326; 530/327; 530/328;
Original: 514/013; 514/014; 514/015; 530/326; 530/327; 530/328;

Field of Search: 514/002,12-18 530/324-330

Priority Number:
1998-09-03  US1998000146268
1995-03-30  US1995000413490
1994-10-14  US1994000323436
1992-09-28  US1992000952818

Abstract:     Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a method for screening compounds capable of binding to a novel allosteric modulatory site, are described.

Attorney, Agent or Firm: Rothwell, Figg, Ernst & Manbeck, p.c. ;

Primary / Asst. Examiners: Allen, Marianne P.;

Maintenance Status: E1 Expired  Check current status

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Related Applications:
Application Number Filed Patent Pub. Date  Title
US1995000413490 1995-03-30    1998-12-29  Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US1994000323436 1994-10-14    1998-11-03  Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US1992000952818 1992-09-28       


       
Parent Case:     This application is a continuation of U.S. application Ser. No. 08/413,490, filed Mar. 30, 1995, now U.S. Pat. No. 5,854,217 which is a continuation-in-part of U.S. application Ser. No. 08/323,436, filed Oct. 14, 1994, now U.S. Pat. No. 5,830,998 which is a continuation-in-part of U.S. application Ser. No. 07/952,818, filed Sep. 28, 1992, now abandoned the disclosures of which are incorporated herein by reference.

Designated Country: AT DK GR LU MC PT SE  BE CH ES FR GB IE IT LI NL  BR CN RU 

Family: Show 28 known family members
First Claim:
Show all 6 claims		 What is claimed is:     1. A composition comprising a compound or pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier, wherein the compound is selected from the group consisting of SEQ ID No:55 GEggLQSNVSQIRAKSN; SEQ ID No:56 GEggLQAALALIRAKSN; SEQ ID No:57 GEggL-gKSN; SEQ ID No:58 GEggL-GG-gKSN; SEQ ID No:59 GEggL-GGGG-gKSN; SEQ ID No:60 GFggL-AA-gKSN; SEQ ID No:61 GEggL-AAA-gKSN; SEQ ID No:62 GEggLQ-AAAAA-gSKN; SEQ ID No:63 GEggLQ-AAAAAAA-gKSN; and SEQ ID No:64 GEggL-BB-gKSN.

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U.S. References: Go to Result Set: All U.S. references   |  No patents reference this one   |   Backward references (14)   |   Citation Link

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PDF		 Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 6pp US4806543  1989-02 Choi  Board of Trustees of the Leland Stanford Junior University Method and compositions for reducing neurotoxic injury
Buy PDF- 6pp US4959493  1990-09 Ohfume et al.  Suntory Limited Carboxycyclopropylglycine and process for producing the same
Buy PDF- 8pp US5049555  1991-09 Rzeszotarski et al.  Nova Pharmaceutical Corporation Antagonists of specific excitatory amino acid receptors as neuroprotectants and anxiolytics
Buy PDF- 29pp US5051403  1991-09 Miljanich et al.  Neurex Corporation Method of treating ischemia-related neuronal damage
Buy PDF- 28pp US5051413  1991-09 Angst et al.  Ciba-Geigy Corporation Unsaturated amino acids
Buy PDF- 9pp US5061721  1991-10 Cordl et al.  G. D. Searle & Co. Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
Buy PDF- 10pp US5086072  1992-02 Trullas et al.  The United States of America as represented by the Department of Health and Human Services Treatment of mood disorders with functional antagonists of the glycine/NMDA receptor complex
Buy PDF- 16pp US5428069  1995-06 Skolnick et al.  The United States of America as represented by the Department of Health & Human Services Treating cognition with, aminocyclopropanecarboxylic derivatives
Buy PDF- 15pp US5432155  1995-07 Olivera et al.  The Salk Institute For Biological Studies Conotoxins I
Buy PDF- 13pp US5523323  1996-06 Maccecchini   Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence
Buy PDF- 47pp US5559095  1996-09 Miljanich et al.  Neurex Corporation Delayed treatment method of reducing ischemia-related neuronal damage
Buy PDF- 67pp US5830998  1998-11 Maccecchini   Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
Buy PDF- 16pp US5844077  1998-12 Saydoff  CytoTherapeutics, Inc. Use of conantokins for producing analgesia or for neuroprotection
Buy PDF- 74pp US5854217  1998-12 Maccecchini  Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
       
Foreign References:
Buy
PDF		 Publication Date IPC Code Assignee   Title
Buy PDF- 17pp EP0514023 1992-11  A61K 31/40 MERCK SHARP & DOHME Use of glycine/NMDA receptor ligands for the manufacture of a medicament for the treatment of drug dependence and withdrawal 
Buy PDF- 41pp WO9101729 1991-02  A61K 31/185 THE UNITED STATES OF AMERICA, as represented by ... PARTIAL AGONISTS OF THE STRYCHNINE INSENSITIVE GLYCINE MODULATORY SITE OF THE N-METHYL-D-ASPARTATE RECEPTOR COMPLEX AS NEUROPSYCHOPHARMACOLOGICAL AGENTS 
Buy PDF- 35pp WO9304688 1993-03  A61K 31/185 WARNER-LAMBERT COMPANY PHARMACEUTICAL PREPARATION CONTAINING AN URICOSURIC AND AN EXCITATORY AMINO ACID ANTAGONIST 
Buy PDF- 62pp WO9407914 1994-04  A61K 38/00 MACCECCHINI MARIA LUISA ALLOSTERIC MODULATORS OF THE NMDA RECEPTOR 
Buy PDF- 113pp WO9611698 1996-04  A61K 38/08 SYMPHONY PHARMACEUTICALS, INC. ALLOSTERIC MODULATORS OF THE NMDA RECEPTOR 


Other Abstract Info: CHEMABS 121(05)050111Z CHEMABS 125(07)076335H CHEMABS 129(26)339877D CHEMABS 130(06)061097M DERABS C1994-135509 DERABS C1996-221755

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