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Title: US6307014: Conopeptides
[ Derwent Title ]
>> View Certificate of Correction for this publication


Country: US United States of America

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19 pages

 
Inventor: Furie, Bruce; Wellesly, MA 02481
Furie, Barbara C.; Wellesly, MA 02481
Stenflo, Johan; S-21620 Malmo, Sweden
Rigby, Alan C.; Boston, MA 02215
Roepstorff, Peter; DK-7000 Fredericia, Denmark

Assignee: None

Published / Filed: 2001-10-23 / 1998-08-19

Application Number: US1998000136769

IPC Code: Advanced: C07K 14/435;
Core: more...
IPC-7: C07K 14/00; C07K 14/435;

ECLA Code: C07K14/435A;

U.S. Class: Current: 530/324; 530/326; 530/333; 530/344;
Original: 530/324; 530/326; 530/333; 530/344; 514/008; 514/012; 514/013;

Field of Search: 514/008,12,13 530/324,326,333,344

Government Interest:

STATEMENT AS TO FEDERALLY SPONSORED RESEARCH
    The invention described herein was supported in whole or in part by grants HL 42443 and HL 18834 from the National Institutes of Health. The government may have certain rights in the invention.

Priority Number:
1998-08-19  US1998000136769

Abstract:     Substantially pure conopeptides containing gamma-carboxyglutamic acid are disclosed.

Primary / Asst. Examiners: Low, Christopher S. F.; Gupta, Anish

Maintenance Status: CC Certificate of Correction issued
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INPADOC Legal Status: Show legal status actions

Family: None

First Claim:
Show all 14 claims
What is claimed is:     1. A substantially pure peptide having the amino acid sequence:
  • Asp Val Pro X1 Ile Val Leu X2 Phe Met Cys Pro Val Ile Cys Gly Asn Gly Phe Gly X3 Glu Tyr Cys Asn Cys Thr (SEQ ID NO:1), wherein each of X1, X2, and X3 is independently selected from Glu and Gla, provided that at least one of X1, X2, and X3 is Gla.


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U.S. References: Go to Result Set: No U.S. references   |  No patents reference this one   |   Backward references (0)

       
Foreign References: None

Other Abstract Info: CHEMABS 135(23)328320Q CHEMABS 135(23)328320Q

Other References:
  • Chandler et al., "Polyamine-like actions of peptides derived from conatokin-G, an N-methyl-D-aspartate (NMDA) antagonist." J. Biol. Chem., 268:17173-17178 (1993). (6 pages) Cited by 9 patents [ISI abstract]
  • Cruz et al., "A preliminary study of Conus venom protein." Veliger, 18:302-308 (1976).
  • Cruz et al., "Conus peptides: Phylogenetic range of biological activity." Biol. Bull., 183:159-164 (1992). (6 pages) Cited by 2 patents [ISI abstract]
  • Czerwiec et al., "Vitamin K-dependent carboxylase: Comparison of the bovine y-carboxylase with the y-carboxylase from the marine snail." Blood 88, (Suppl. 1):523a (1996).
  • Fainzilber et al., "Mollusc-specific toxins from the venom of Conus textile neovicarius." Eur. J. Biochem., 588-595 (1991).
  • Haack et al., "Conantokin-T: a y-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activity" J. Biol. Chem., 265:6025-6029 (1989).
  • McIntosh et al., "y-carboxyglutamate in a neuroactive toxin," J. Biol. Chem., 259:14343-14346 (1984).
  • Mena et al., "Conantokin-G: A novel peptide antagonist to the N-methyl-D-aspartic (NMDA) receptor." Neurosci. Lett., 118:241-244 (1990). (4 pages) Cited by 11 patents
  • Nakamura et al., "Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with y-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile," Protein Sci., 5:524-530 (1996). (7 pages) Cited by 3 patents [ISI abstract]
  • Olivera et al., "Peptide neurotoxins from fish-hunting cone snails." Science, 230:1338-1343 (1985). (6 pages) Cited by 25 patents
  • Olivera et al., "Diversity of Conus neuropeptides." Science, 249:257-263 (1990). (7 pages) Cited by 36 patents
  • Olivera et al., "Conotoxins." J. Biol. Chem., 33:22067-22070 (1991). (4 pages) Cited by 30 patents [ISI abstract]
  • Rigby et al., "Three dimensional structure of a y-carboxyglutamic acid-containing conotoxin, conantokin-G, from the marine cone snail Conus geographus: The metal-free conformer." Biochemistry 36:6906-6914 (1997). (9 pages) [ISI abstract]
  • Rigby et al., "The role of y-carboxyglutamic acid in the calcium-induced structural transition of conantokin-G, a contoxin from the marine cone snail Conus geographus." Biochemistry 36:15677-15684 (1997). (8 pages) [ISI abstract]
  • Skjaerbaek et al., "Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy." J. Biol. Chem., 272:2291-2299 (1997). (9 pages) [ISI abstract]
  • Woodward et al., "Constant and hypervariable regions in conotoxin propeptides." EMBO J., 9:1051-1020 (1990).
  • Zhou et al., "Synthetic analogues of conantokin G: NMDA antagonists acting through a novel polyamine-coupled site." J. Neurochem., 66:620-628 (1996). (9 pages) Cited by 7 patents [ISI abstract]


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