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Title: US6309643: IBD-associated microbial antigens and methods of using same
[ Derwent Title ]

Country: US United States of America

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28 pages

 
Inventor: Braun, Jonathan; Tarzana, CA
Sutton, Christopher; Encinitas, CA

Assignee: The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2001-10-30 / 1999-04-30

Application Number: US1999000303120
IPC Code: Advanced: A61K 38/00; A61K 45/00; A61P 1/04; A61P 29/00; C07K 14/195; C07K 14/33; C07K 14/35; C07K 16/12; C12N 15/09; C12P 21/08; C12Q 1/02; G01N 33/53;
Core: A61P 1/00; more...
IPC-7: A01K 39/00; A01K 39/38; C07K 5/00; C07K 16/00; C07K 17/00;

ECLA Code: C07K14/33; C07K14/35;

U.S. Class: Current: 424/185.1; 424/184.1; 435/003; 435/004; 435/007.1; 530/324; 530/325; 530/326; 530/327; 530/328; 530/350;
Original: 424/185.1; 424/184.1; 530/324; 530/325; 530/326; 530/327; 530/328; 530/350; 435/007.1; 435/003; 435/004;

Field of Search: 435/7.1,3,4 530/324,328,325,326,327,350 424/184.1,185.1

Government Interest:

ACKNOWLEDGMENT
    This work was supported by grant number DK46763 awarded by the National Institutes of Health. The United States government has certain rights in this invention.

Priority Number:
1999-04-30  US1999000303120

Abstract:     The present invention provides nucleic acid and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD). Methods of diagnosing and treating inflammatory bowel disease using the IBD-associated I-1 and I-2 antigens also are provided.

Attorney, Agent or Firm: Campbell & Flores ;

Primary / Asst. Examiners: Nelson, Brett L.;

INPADOC Legal Status: Show legal status actions          Buy Now: Family Legal Status Report

Designated Country: AE AG AL AM AP AT AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP 

Family: Show 16 known family members
First Claim:
Show all 11 claims		 We claim:     1. An isolated inflammatory bowel disease associated I-2 polypeptide, comprising at least 60% amino acid identity with SEQ ID NO: 2, said polypeptide having differential reactivity with Crohn's disease patient sera as compared to normal sera.

Background / Summary: Show background / summary

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Description: Show description

Forward References: Show 1 U.S. patent(s) that reference this one

       
U.S. References: Go to Result Set: All U.S. references   |  Forward references (1)   |   Backward references (0)   |   Citation Link

       
Foreign References: None

Other Abstract Info: CHEMABS 133(25)349128G

Other References:
  • Accession No. 481591.
  • Accession No. 2984362.
  • Accession No. 1877288.
  • Accession No. 730078.
  • Blaser et al., "Patients With Active Crohn's Disease Have Elevated Serum Antibodies to Antigens of Seven Enteric Bacterial Pathogens," Gastroenterology 87:888-894 (1984). (7 pages) Cited by 4 patents
  • Brandwein et al., "Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora," J. Immunol. 159:44-52 (1997). (9 pages) Cited by 6 patents [ISI abstract]
  • Bregenholt et al., T-cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease, APMIS 105:655-662 (1997). (8 pages) Cited by 3 patents [ISI abstract]
  • Cellier et al., "Mycobacterium paratuberculosis and Mycobacterium avim subsp. Silvaticum DNA cannot be detected by PCR in Crohn's disease tissue," Gastroenterol. Clin. Biol. 22:675-678 (1998). (4 pages) Cited by 4 patents [ISI abstract]
  • Chang et al., "Identification of Herpesvirus-Like DNA Sequences in AIDS-Associated Kaposi's Sarcoma," Science 266:1865-1869 (1994). (5 pages) Cited by 41 patents [ISI abstract]
  • Chiba et al., "No Mycobacterium paratuberculosis detected in intestinal tissue, including Peyer's patches and lymph follicles, of Crohn's disease," J. Gastroenterology 33:482-487 (1998). (6 pages) Cited by 4 patents [ISI abstract]
  • Clarkston et al., "Role of Mycobacterium Paratuberculosis in Crohn's Disease," Dis. Colon Rectum 41:195-199 (1998). (5 pages) Cited by 4 patents [ISI abstract]
  • Cocito et al., "Paratuberculosis," Clinical Microbiology Reviews 7(3):328-345 (1994). (18 pages) Cited by 4 patents [ISI abstract]
  • Cong et al., "CD4+ T cells reactie to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease," J. Exp. Med. 187:855-864 (1998). (10 pages) Cited by 8 patents [ISI abstract]
  • Dalwadi et al., "Identification of a novel IBD-Associated microbial agent by representational difference analysis," Gastroenterology 116(4): A696 AGA Abstracts (1999). (1 pages) Cited by 4 patents [ISI abstract]
  • Davidson et al., "Antibodies to maize in patient with Crohn's disease, ulcerative colitis and coeliac disease," Clin. Exp. Immunol. 35:147-148 (1979). (2 pages) Cited by 3 patents
  • Del Prete et al., "Detection of Mycobacterium paratuberculosis in stool samples of patients with inflammatory bowel disease by IS900-based PCR and colorimetric detection of amplified DNA," J. Microbiol. Methods 33:105-114 (1998). (10 pages) [ISI abstract]
  • Dianda et al., "T cell receptor-αβ-deficient mice fail to develop colitis in the absence of a microbial environment," Am. J. Pathol. 150:91-97 (1997). (7 pages) Cited by 4 patents [ISI abstract]
  • El-Zaatari et al., "Characterization of a Specific Mycobacterium paratuberculosis Recombinant Clone Expressing 35,000-Molecular-Weight Antigen and Reactivity with Sera from Animals with Clinical and Subclinical Johne's Disease," Journal of Clinical Microbiology 35(7):1794-1799 (1997). (6 pages) [ISI abstract]
  • Elsaghier et al., "Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease," Clin. Exp. Immunol. 90:503-508 (1992). (6 pages) Cited by 8 patents [ISI abstract]
  • Fidler et al., "Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease," Gut 35:506-510 (1994). (5 pages) Cited by 5 patents [ISI abstract]
  • Gui et al., "Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics," J. Antimicrob. Chemother. 39:393-400 (1997). (8 pages) Cited by 4 patents [ISI abstract]
  • Herfarth et al., "Interleukin 10 suppresses experimental chronic, granulomatous inflammation induced by bacterial cell wall polymers," Gut 39:836-845 (1996). (10 pages) Cited by 5 patents [ISI abstract]
  • Hornquist et al., "Gαi2-Deficient Mice with Colitis Exhibit a Local Increase in Memory CD4+ T Cells and Proinflammatory Th1-Type Cytokines," J. Immunol. 158:1068-1077 (1997). (10 pages) Cited by 2 patents [ISI abstract]
  • Janowitz et al., "The role of the fecal stream in Crohn's disease: an historical and analytic review," Inflamm. Bowel. Dis. 4:29-39 (1998). (11 pages) Cited by 4 patents [ISI abstract]
  • Knoflach et al., "Serum Antibodies to Cow's Milk Proteins in Ulcerative Colitis and Crohn's Disease," Gastroenterology 92:479-485 (1987). (7 pages) Cited by 4 patents
  • Ku hn et al., "Interleukin-10-deficient Mice Develop Chronic Enterocolitis," Cell 75:263-274 (1993).
  • Metcalf, "Is measles infection associated with Crohn's disease?," Brit. Med. J. 316:166 (1998). (1 pages) Cited by 3 patents [ISI abstract]
  • Mombaerts et al., "Spontaneous Development of Inflammatory Bowel Disease in T Cell Receptor Mutant Mice," Cell 75:275-282 (1993). (8 pages) Cited by 6 patents [ISI abstract]
  • Morrissey et al., "CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into cogenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells," J. Exp. Med. 178:237-244 (1993). (8 pages) Cited by 4 patents [ISI abstract]
  • Moss et al., "Polymerase chain reaction detection of Mycobacterium paratuberculosis and Mycobacterium avium subsp silvaticum in long term cultures from Crohn's disease and control tissues," Gut 33:1209-1213 (1992). (5 pages) Cited by 4 patents [ISI abstract]
  • Podolsky, "Lessons from genetic models of inflammatory bowel disease," Acta Gastro-Enterol. Belg. 60:163-165 (1997). (3 pages) Cited by 3 patents [ISI abstract]
  • Powrie et al., "Inhibition of Th1 Responses Prevents Inflammatory Bowel Disease in scid Mice Reconstituted with CD45RBhi CD4+ T Cells," Immunity 1:553-562 (1994). (10 pages) Cited by 12 patents [ISI abstract]
  • Prantera et al., "An Antibiotic Regimen for the Treatment of Active Crohn's Disease: A Randomized, controlled Clinical Trail of Metronidazole plus Ciprofloxacin," Am. J. Gastroenterol. 91:328-332 (1996). (5 pages) Cited by 10 patents [ISI abstract]
  • Rudolph et al., "Ulcerative colitis and adenocarcinoma of the colon in Gαi2 -deficient mice," Nat. Genet. 10:143-149 (1995). (8 pages) Cited by 4 patents [ISI abstract]
  • Rudolphi et al., "Polyclonal expansion of adoptively transferred CD4+ αβ T cells in the colonic lamina propria of scid mice with colitis," Eur. J. Immunol 26:1156-1163 (1996). (8 pages) Cited by 4 patents [ISI abstract]
  • Sadlack et al., "Ulcerative Colitis-like Disease in Mice with a Disrupted Interleukin-2 Gene," Cell 75:253-261 (1993). (9 pages) Cited by 11 patents [ISI abstract]
  • Sanderson et al., "Mycobacterium paratuberculosis DNA in Crohn's disease tissue," Gut 33:890-896 (1992). (7 pages) Cited by 5 patents [ISI abstract]
  • Seibold et al., "pANCA Represents a Cross-Reactivity to Enteric Bacterial Antigens," Journal of Clinical Immunology 18(2):153-160 (1998). (8 pages) Cited by 4 patents [ISI abstract]
  • Sendid et al., "Specific antibody response to oligomannosidic epitopes in Crohn's disease," Clin. Diag. Lab. Immunol. 3:219-226 (1996). (8 pages) Cited by 8 patents [ISI abstract]
  • Sonnenberg, "Occupational distribution of inflammatory bowel disease among German employees," Gut 31:1037-1040 (1990). (4 pages) Cited by 4 patents
  • Thomas et al., "Controlled trial of antituberculous chemotherapy in Crohn's disease: a five year follow up study," Gut 42:497-500 (1998). (4 pages) [ISI abstract]
  • Vannuffel et al., "Occurrence, in Crohn's Disease, of Antibodies Directed against a Species-Specific Recombinant Polypeptide of Mycobacterium paratuberculosis," Clinical and Diagnostic Laboratory Immunology 1(2):241-243 (1994). (3 pages) Cited by 4 patents [ISI abstract]
  • Wayne et al., "Immunoglobulin A (IgA) and IgG Serum Antibodies to Mycobacterial Antigens in Crohn's Disease Patients and Their Relatives," Journal of Clinical Microbiology 30(8):2013-2018 (1992). (6 pages) Cited by 4 patents [ISI abstract]
  • Weiner, "Oral Tolerance: Mobilizing the Gut," Hospital Practice 53-58 (1995). (6 pages) Cited by 3 patents [ISI abstract]
  • Weiner et al., "Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens," Ann. Rev. Immunol., 12:809-837 (1994). (29 pages) Cited by 48 patents [ISI abstract]
  • Meyer; Clostridium pasteurianum; EMBL; accession No. 481591, Nov. 1993.


    • Continuity Data:
    Application Number Filed Notes
    US1999000303120 1999-04-30  is a related to the prior publication
         US20040197871A1 issued 2004-10-07  IBD-associated microbial nucleic acid molecules
    US2004000835914 2004-04-30  is a continuation of
    US2001000966608  2001-09-27   (granted)
         US6759530 issued 2004-07-06   IBD-associated microbial nucleic acid molecules
    US2004000835914   is a continuation of
    US2001000966608  2001-09-27
         US6759530 issued 2004-07-06   IBD-associated microbial nucleic acid molecules
    US2001000966608 2001-09-27  is a continuation of
    US2001000820576  2001-03-28   (granted)
         US6320037 issued 2001-11-20   IBD-associated microbial nucleic acid molecules
    US2001000966608 2001-09-27  is a continuation of
    US2001000820576  2001-03-28   (patented) [presumed granted]
         US6320037 issued 2001-11-20   IBD-associated microbial nucleic acid molecules
    US2001000966608   is a continuation of
    US2001000820576  2001-03-28
         US6320037 issued 2001-11-20   IBD-associated microbial nucleic acid molecules
    US2001000820576 2001-03-28  is a division of
    >US1999000303120<  1999-04-30   (pending) [presumed granted]
         US6309643 issued 2001-10-30   IBD-associated microbial antigens and methods of using same
    US2001000820576 2001-03-28  is a division of
    >US1999000303120<  1999-04-30   (granted)
         US6309643 issued 2001-10-30   IBD-associated microbial antigens and methods of using same
    US2001000820576 2001-03-28  is a division of
    >US1999000303120<  1999-04-30   (patented) [presumed granted]
         US6309643 issued 2001-10-30   IBD-associated microbial antigens and methods of using same
    US2001000820576   is a division of
    >US1999000303120<  1999-04-30
         US6309643 issued 2001-10-30   IBD-associated microbial antigens and methods of using same


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