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Title: US6310188: Method for producing chitin or chitosan
[ Derwent Title ]

Country: US United States of America

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4 pages

Inventor: Mukherjee, Debi P.; Shreveport, LA

Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA
other patents from LOUISIANA STATE UNIVERSITY (343025) (approx. 62)
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Published / Filed: 2001-10-30 / 2000-01-24

Application Number: US2000000490763

IPC Code: Advanced: A61K 9/48; C08B 37/08;
Core: C08B 37/00; more...
IPC-7: C08B 37/08;

ECLA Code: A61K9/48B; C08B37/00M3B2;

U.S. Class: Current: 536/020; 536/127;
Original: 536/020; 536/127;

Field of Search: 536/020,127

Priority Number:
2000-01-24  US2000000490763

Abstract:     A method is disclosed for improving the efficiency of producing chitin and chitosan, particularly biocompatible chitosan. Crustacean shells are maintained at a high temperature for a sufficient time to convert most of the chitin in the shells to an amorphous form. The shells are then rapidly cooled, for example by plunging into liquid nitrogen, so that most of the chitin in the shells remains in the amorphous form. These "quenched" shells are then deproteinized and demineralized to produce chitin. The chitin may be deacetylated to produce chitosan. High purity chitin or chitosan is thereby produced at a lower cost than has been possible using previous methods. Biocompatible chitosan produced by this process may be used for the delivery of cells or bioactive agents, or for other applications. It is believed that the heating followed by immediate quenching enhances the formation of chitin chains in an amorphous or a relaxed form, making them more susceptible to attack by acid or alkali during the subsequent treatment steps. Making the chitin amorphous allows the more efficient and economical production of chitosan, using lower quantities of chemicals such as hydrochloric acid and sodium hydroxide, thus making the entire production process both more economical and less polluting.

Attorney, Agent or Firm: Runnels, John H. ;

Primary / Asst. Examiners: Wilson, James O.; Maier, Leigh C.

Maintenance Status: E2 Expired  Check current status

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First Claim:
Show all 12 claims
I claim:     1. A process for preparing chitin-containing, cleaned crustacean shells for chitin production or for chitosan production, said process comprising the steps of:
  • (a) maintaining the shells at a temperature above about 78° C. for more than about 24 hours; and
  • (b) cooling the shells by transferring the shells immediately from the maintained temperature into liquid nitrogen.

Background / Summary: Show background / summary

Drawing Descriptions: Show drawing descriptions

Description: Show description

Forward References: Show 5 U.S. patent(s) that reference this one

U.S. References: Go to Result Set: All U.S. references   |  Forward references (5)   |   Backward references (3)   |   Citation Link

Patent  Pub.Date  Inventor Assignee   Title
Get PDF - 5pp US4066735  1978-01 Peniston et al.   Process for demineralization of crustacea shells
Get PDF - 5pp US4195175  1980-03 Peniston et al.   Process for the manufacture of chitosan
Foreign References: None

Other Abstract Info: CHEMABS 135(23)332681A CHEMABS 135(23)332681A

Other References:
  • No, H. et al., "Preparation of chitin and chitosan," pp. 475-489 in R. Muzzarelli et al. (Eds.), Chitin Handbook (1997).
  • Caplus abstract of Signini, R. et al "Purification and characterization of commercial chitosan" Polim.: Cienc. Tecnol. vol. 8 No. 4 pp. 63-68, 1998.*
  • Bienvenu, J., "Development of a Process to Produce Chitosan from Crawfish Waste," report presented at Louisiana Region I Science and Engineering Fair, Bossier City, Louisiana (Mar. 18-19, 1999); and at the International Science and Engineering Fair, Philadelphia, Pennsylvania (May 1999).

  • Continuity Data:
    Application Number Filed Notes

    US2001000952129 2001-09-12  is a continuation of
    >US2000000490763<  2000-01-24   (granted)
         US6310188 issued 2001-10-30   Method for producing chitin or chitosan

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