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 Title: |
US6326148:
Detection of copy number changes in colon cancer
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Pauletti, Giovanni E.; Santa Monica, CA
Slamon, Dennis J.; Woodland Hills, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2001-12-04
/ 1999-07-12
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| Application Number: |
US1999000351763
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| IPC Code: |
Advanced:
C12Q 1/68;
Core:
more...
IPC-7:
C12Q 1/68;
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| ECLA Code: |
C12Q1/68M6B;
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| U.S. Class: |
Current:
435/006;
Original:
435/006;
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| Field of Search: |
435/006
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| Priority Number: |
| 1999-07-12 |
US1999000351763 |
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| Abstract: |
The present invention provides methods of screening for colon carcinoma cells in a sample. The methods comprise providing a nucleic acid sample from a premalignant lesion in colorectal tissue from a human patient and contacting the sample with a nucleic acid probe that selectively hybridizes to a chromosomal region at 20q.
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| Attorney, Agent or Firm: |
Townsend and Townsend and Crew LLP ;
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| Primary / Asst. Examiners: |
Arthur, Lisa B.; Goldberg, Jeanine
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| INPADOC Legal Status: |
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Family Legal Status Report
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| Designated Country: |
AE AG AL AM AP AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS
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| Family: |
Show 8 known family members
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First Claim:
Show all 25 claims |
What is claimed is:
1. A method of screening for colon carcinoma precursor cells in a sample by determining the presence of increased copy number of chromosome 20q, the method comprising:
- providing a nucleic acid sample from a premalignant lesion in colorectal tissue from a human patient;
- contacting the sample with a nucleic acid probe that selectively hybridizes to a chromosomal region on 20q; and
- detecting the formation of a hybridization complex, whereby the presence of increased copy number on 20q indicates the presence of colon cancer precursor cells.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 2 U.S. patent(s) that reference this one
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| Foreign References: |
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| Other Abstract Info: |
CHEMABS 136(01)001598Q
CHEMABS 136(01)001598Q
CHEMABS 136(07)100613X
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| Other References: |
Ried et al "Comparative Genomic Hybridization Reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors" Genes, Chromosomes, and Cancer, vol. 15, p. 235-245, 1996.*
Collins et al "Positional cloning of ZNF217 and NABC1: Genes amplified at 20q13.2 and overexpressed in breast carcinoma" Proc. Natl. Acad. vol. 95, p. 8703-8708, Jul. 1998.*
(6 pages)
Cited by 6 patents
[ISI abstract]
Wang et at "Cot-1 Banding of Human choromosomes using FISH hybridization with CY3 labeling" Jpn. J. Hum. Genetics, vol. 40, p. 243-252, 1995.*
(10 pages)
Cited by 4 patents
[ISI abstract]
Korn et al "Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastic to liver, as analyzed by CGH and FISH" Genes, Chromosomes, and Cancer, vol. 25, p. 82-90, Jun. 1999.*
(9 pages)
Cited by 2 patents
[ISI abstract]
Brown et al "Exploring the new world of the genome with DNA microarrays" Nature Genetics Supplement, vol. 21, p. 33-37, Jan. 1999.*
(5 pages)
Cited by 7 patents
[ISI abstract]
Schlegel et al "Comparative Genomic in Situ hybridization of Colon carcinomas with Replication error" Cancer Research, vol. 55, p. 6002-6005, Dec. 1995.*
(4 pages)
Cited by 7 patents
[ISI abstract]
Nanashima et al "Gain of Chromosome 20 is a frequent aberration in liver metastasis of colorectal cancers" Digestive Disease and Sciences, vol. 42, No. 7, p. 1388-1393, Jul. 1997.*
(6 pages)
[ISI abstract]
Korn et al "Characterization of copy number increases of chromosome 20q sequences in hepatic of colorectal cancer by FISH" Proc. of the Am. Association for Cancer Research, vol. 39, p. 346, Mar. 1998.*
Bischoff et al "A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers" The EMBO Journal, vol. 17, No. 11, p. 3052-3065, Jun. 17, 1998.*
(14 pages)
Cited by 7 patents
[ISI abstract]
Savelieva et al "20q gain associates with immortalization: 20q13.2 amplification correlates with genome instability in human papillomavirus 16 E7 transformed human uroepithelial cells" Oncogene, vol. 14, No. 5, p. 551-560, Feb. 1997.*
(10 pages)
Cited by 4 patents
[ISI abstract]
Nakao et al "Genetic Changes in Primary colorectal cancer by CGH" Jpn. J. Surg. vol. 28, No. 5, p. 567-569, 1998.*
(3 pages)
[ISI abstract]
Meijer et al "Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by CGH" J. Clinical Pathology, vol. 51, p. 901-909, Dec. 1998.*
(9 pages)
[ISI abstract]
Baker et al., "p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis," Cancer Research (1990) 50: 7717-22.
(6 pages)
Cited by 13 patents
Fearon and Vogelstein, "A genetic model for colorectal tumorigenesis," Cell (1990) 61: 759-767.
(9 pages)
Cited by 40 patents
Vogelstein et al., "Genetic alterations during colorectal-tumor development," New England Journal of Medicine (1988) 319: 525.
(8 pages)
Cited by 71 patents
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