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 Title: |
US6350769:
Gaba alpha receptors mediate inhibition of T cell responses
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
Kaufman, Daniel L.; Santa Monica, CA
Tian, Jide; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2002-02-26
/ 2000-02-24
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| Application Number: |
US2000000513259
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| IPC Code: |
Advanced:
A61K 31/00;
A61K 31/42;
A61K 45/06;
Core:
A61K 45/00;
more...
IPC-7:
A61K 31/195;
A61K 31/47;
A61K 31/50;
A61K 31/55;
A61K 31/56;
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| ECLA Code: |
A61K31/00; A61K31/42+A; A61K45/06;
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| U.S. Class: |
Current:
514/380;
514/182;
514/221;
514/249;
514/567;
Original:
514/380;
514/182;
514/221;
514/249;
514/567;
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| Field of Search: |
514/380,567,249,182,221
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| Government Interest: |
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT
This invention was made with Government support under Grant Nos. A143712 awarded by the National Institutes of Health and 196061 awarded by the Juvenile Diabetes Foundation International Research Award. The Government has certain rights in this invention.
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| Priority Number: |
| 2000-02-24 |
US2000000513259 |
| 1999-02-24 |
US1999000121352P |
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| Abstract: |
The present invention provides new methods for modulating immune responses. The methods are based on the discovery that GABAA receptors are present on peripheral lymphocytes. Thus, GABA agonists and antagonists can be used to modulate immune responses.
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| Attorney, Agent or Firm: |
Townsend & Townsend & Crew LLP ;
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| Primary / Asst. Examiners: |
Weddington, Kevin E.;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
CROSS-REFERENCES TO RELATED APPLICATIONS
The present application claims priority to the U.S. Provisional Application No. 60/121,352 filed Feb. 24, 1999, herein incorporated by reference in its entirety.
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| Designated Country: |
AE AL AM AP AT AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EA EE EP ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG
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| Family: |
Show 4 known family members
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First Claim:
Show all 9 claims |
What is claimed is:
1. A method of inhibiting an immune response in a patient, the method comprising administering an immunomodulatory amount of a GABA agonist.
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| Background / Summary: |
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| Drawing Descriptions: |
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| Description: |
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| Forward References: |
Show 2 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 133(13)172182S
DERABS C2000-565414
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| Other References: |
Devoino et al., "Immunomodulating effect of activators and blockers of the GABA-receptor-ionophore complex", Farmakol. Toksikol. (Moscow) (1988), 51(3), pp. 78-80 (abstract),*
(3 pages)
Bergeret et al. (1998) GABA modulates cytotoxicity of immunocompetent cells expressing GABAA receptor subunits Biomed. Pharmacother. 52(5): 214-219.
(6 pages)
[ISI abstract]
Defeudis et al. (1998) Muscimol and central nervous system gamma-aminobutyric amino acid receptors: studies with ligand binding techniques (1986) in Receptors, vol. 3, Eds. Conn, P.M., Publ. Academic, Orlando, FL.
Ratnikov et al. (1982) Effect of GABA-ergic substances on humoral immunity Biull.Eksp.Biol.Med. 94:56-58.
International Search Report mailed May 30, 2000 for International Application No. PCT/US00/04921.
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