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 Title: |
US6465627:
DAX-1 protein, methods for production and use thereof
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
McCabe, Edward R. B.; Pacific Palisades, CA
Guo, Weiwen; Los Angeles, CA
Burris, Thomas P.; Woodland Hills, CA
Vilain, Eric; Los Angeles, CA
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| Assignee: |
The Regents of the University of California, Oakland, CA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2002-10-15
/ 1996-07-26
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| Application Number: |
US1996000687691
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| IPC Code: |
Advanced:
C07K 14/705;
C07K 14/72;
Core:
C07K 14/435;
IPC-7:
C12N 15/11;
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| ECLA Code: |
C07K14/705G; C07K14/72A;
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| U.S. Class: |
536/023.1;
536/024.1;
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| Field of Search: |
435/69.1,320.1,172.3,325,6
536/23.1,23.5,24.1
436/015
514/044
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| Government Interest: |
This invention was made with support under Grant Numbers RO1 HD22563, P30 HD24064, P30 HD27823, and P50 HG00210 from the National Institute of Health, U.S. Department of Health and Human Resources and ACS PF-4074. Accordingly, the U.S. Government may have certain rights in the invention.
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| Priority Number: |
| 1996-07-26 |
US1996000687691 |
| 1995-07-28 |
US1995000001713P |
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| Abstract: |
The invention provides a DAX-1 protein molecule having the amino acid sequence beginning with methionine at position 1 and ending with isoleucine at position 470 as shown in FIG. 12. The invention further provides the genomic nucleic acid sequence for DAX-1, including intron, exons and a promoter region. Additionally, the invention provides methods for using and making the DAX-1 protein and DAX-1 nucleic acid molecules.
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| Attorney, Agent or Firm: |
Mandel & Adriano ;
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| Primary / Asst. Examiners: |
Martinell, James;
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| INPADOC Legal Status: |
Show legal status actions
Family Legal Status Report
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| Parent Case: |
This application is based on a provisional application, U.S. Serial No. 60/001,713, filed Jul. 28, 1995.
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| Designated Country: |
AU CA EP JP
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| Family: |
Show 4 known family members
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First Claim:
Show all 3 claims |
What is claimed is:
1. A nucleic acid molecule consisting of a nucleotide sequence beginning with position 1 and ending with position 1579 of SEQ ID NO.: 1.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
Show description
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| Forward References: |
Show 1 U.S. patent(s) that reference this one
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| Foreign References: |
None
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| Other Abstract Info: |
CHEMABS 126(16)208222B
DERABS C1997-145382
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| Other References: |
Stanesh, Dictionary of Biochemistry and Molecular Biology, 2nd Edition, 1989, p. 490.*
Guo et al, Biochemical and Molecular Medicine 56: 8 (1995).*
(6 pages)
[ISI abstract]
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[ISI abstract]
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[ISI abstract]
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(14 pages)
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Cited by 207 patents
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(2 pages)
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(8 pages)
Guo, W. et al. (1993) Genomic scanning for expressed sequences in Xp21 identifies the glycerol kinase gene, Nature Genet. 4:367-372 (Exhibit 10).
(6 pages)
[ISI abstract]
Guo, W. et al.
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(7 pages)
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(6 pages)
[ISI abstract]
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(11 pages)
Cited by 8 patents
[ISI abstract]
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(5 pages)
Cited by 14 patents
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(10 pages)
[ISI abstract]
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(4 pages)
[ISI abstract]
McCabe, E.R.B. (1995) Disorders of glycerol metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic Basis of Inherited Disease, 7th ed., New York, McGraw-Hill, 1631-1652 (Exhibit 21).
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(6 pages)
[ISI abstract]
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(9 pages)
Cited by 30 patents
[ISI abstract]
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(3 pages)
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(4 pages)
Cited by 194 patents
[ISI abstract]
Schena, M. and Yamamoto, K. R. (1988) Mammalian glucocorticoid receptor derivatives enhance transcription in yeast, Science 241:965-967 (Exhibit 28).
(3 pages)
Cited by 6 patents
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(11 pages)
Walker, A. P. et al. (1993) Isolation of the human Xp21 glycerol kinase gene by positional cloning, Hum. Mol. Genet. 2:107-114 (Exhibit 30).
(8 pages)
[ISI abstract]
Wang, L. H. et al. (1989) COUP transcription factor is a member of the steroid receptor superfamily, Nature 340:163-166 (Exhibit 31).
(4 pages)
Cited by 29 patents
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(5 pages)
[ISI abstract]
Worley, K.C. et al. (1993) Yeast artificial chromosome cloning in the glycerol kinase and adrenal hypoplasia congenita region of Xp21, Genomics 16:407-416 (Exhibit 33).
(10 pages)
[ISI abstract]
Yates, J.R.W. et al. (1987) A deletion of Xp21 maps congenital adrenal hypoplasia distal to glycerol kinase deficiency, Cytogenet. Cell Genet. 46:723 (Exhibit 34).
(2 pages)
Zanaria, E. et al. (1994) An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita, Nature 372:635-641 (Exhibit 35).
(7 pages)
Cited by 3 patents
[ISI abstract]
Guo et al., "Diagnosis of X-linked Adrenal Hypoplasia Congenita By Mutation Analysis off the DAX1 Gene", Journal of the American Medical Association, vol. 274, No. 04, Jul. 26, 1995; pp. 324-330.
(7 pages)
Cited by 3 patents
[ISI abstract]
Muscatelli et al., "Mutations in the DAX-1 Gene Give Rise to Both X-linked Adrenal Hypoplasia Congenita and Hypogonadotropic Hypogonadism", Nature, vol. 372, Dec. 15, 1994, pp. 672-676.
(5 pages)
Cited by 3 patents
[ISI abstract]
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