 Other References: |
Merrifield, R.B., "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide," Journal of the American Chemical Society, 1963, 85:2149-54. (Exhibit 4).
Mosmann, Timothy R. et al., "Two Types of Murine Helper T Cell Clone I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins," The Journal of Immunology, Apr. 1, 1986, 136:2348-57. (Exhibit 5).
(10 pages)
Cited by 19 patents
Hoffmann, Petra et al., "Stimulation of Human and Murine Adherent Cells by Bacterial Lipoprotein and Synthetic Lipopeptide Analogues," Immunobiology, 1988, 177:158-70. (Exhibit 6).
(13 pages)
Cited by 13 patents
Scott, Phillip et al., "Immunoregulation of Cutaneous Leishmaniasis T Cell Lines that Transfer Protective Immunity or Exacerbation Belong to Different T Helper Subsets and Respond to Distinct Parasite Antigens," The Journal of Experimental Medicine, Nov. 1, 1988, 168:1675-84. (Exhibit 7).
(10 pages)
Cited by 2 patents
Heinzel, Frederick P. et al., "Reciprocal Expression of Interferon γ or Interleukin 4 During the Resolution or Progression of Murine Leishmaniasis Evidence for Expansion of Distinct Helper T Cell Subsets," The Journal of Experimental Medicine, Jan. 1, 1989, 169:59-72. (Exhibit 8).
(14 pages)
Cited by 6 patents
Ashbridge, Kevin R. et al., "Nucleotide Sequence of the 19 kDa Antigen Gene From Mycobacterium tuberculosis," Nucleic Acids Research, 1989, 17:1249. (Exhibit 9).
(1 pages)
Cited by 5 patents
Liew, Foo Y. et al., "Macrophage Activation by Interferon-γ from Host-Protective T Cells is Inhibited by Interleukin (IL)3 and IL4 Produced by Disease-Promoting T Cells in Leishmaniasis," European Journal of Immunology, 1989, 19:1227-32 (Exhibit 10).
(6 pages)
Cited by 3 patents
Sadick, Michael D. et al., "Cure of Murine Leishmaniasis with Anti-Interleukin 4 Monoclonal Antibody Evidence for a T Cell-dependent, Interferon γ-independent Mechanism," The Journal of Experimental Medicine, Jan. 1, 1990, 171:115-27. (Exhibit 11).
(13 pages)
Cited by 5 patents
Hauschildt, Sunna et al., "Activation of Bone Marrow-Deprived Mouse Macrophages by Bacterial Lipopeptide: Cytokine Production Phagocytosis and la Expression," European Journal of Immunology, 1990, 20:63-8. (Exhibit 12).
(6 pages)
Yamamura, Masahiro et al., "Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions," Oct. 11, 1991, 154:277-9. (Exhibit 13).
(3 pages)
Cited by 24 patents
[ISI abstract]
Salgame, Padmini et al., "Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones," Science, Oct. 11, 1991, 254:279-82. (Exhibit 14).
(4 pages)
Cited by 10 patents
[ISI abstract]
Romagnani, Sergio, "Induction of TH1 and TH2 Responses: A Key Role for The `Natural` Immune Response?" Immunology Today, 1992, 13:379-81. (Exhibit 15).
(3 pages)
Cited by 6 patents
[ISI abstract]
Bloom, Barry R. and Murray, Christopher J.L., "Tuberculosis: Commentary of A Reemergent Killer," Science, Aug. 21, 1992, 257:1055-64. (Exhibit 16).
(10 pages)
Cited by 24 patents
[ISI abstract]
D'Andrea, Annalisa et al., "Production of Natural Killer Cell Stimulatory Factor (Interleukin 12) by Peripheral Blood Mononuclear Cells," The Journal of Expreimental Medicine, Nov. 1992, 176:1387-98. (Exhibit 17).
(12 pages)
Cited by 17 patents
[ISI abstract]
Hsieh, Chyi-Song et al., "Development of Th1 CD4+ T Cells Through IL-12 Produced by Listeria-Induced Macrophages," Science, Apr. 23, 1993, 260:547-9. (Exhibit 18).
(3 pages)
Cited by 27 patents
[ISI abstract]
Heinzel, F.P. et al., "Recombinant Interleukin 12 Cures Mice Infected with Leishmania major," Journal of Experimental Medicine, May 1993, 177:1505-9. (Exhibit 19).
(5 pages)
Cited by 25 patents
[ISI abstract]
Cooper, Andrea M. et al., "Disseminated Tuberculosis in Interferon γ Gene-disrupted Mice," The Journal of Experimental Medicine, Dec. 1993, 178:2243-7. (Exhibit 20).
(5 pages)
Cited by 4 patents
[ISI abstract]
Flynn, JoAnne L. et al., "An Essential Role for Interferon γ in Resistance to Mycobacterium tuberculosis Infection," The Journal of Experimental Medicine, Dec. 1993, 178:2249-54. (Exhibit 21).
(6 pages)
Cited by 5 patents
[ISI abstract]
Zhang, Ming et al., "Interleukin 12 at the Site of Disease in Tuberculosis," The Journal of Clinical Investigation, Apr. 1994, 93:1733-9. (Exhibit 22).
(7 pages)
Cited by 4 patents
[ISI abstract]
Ma, Ying et al., "Outer Surface Lipoproteins of Borrelia burgdorferi Stimulate Nitric Oxide Production by the Cytokine-Inducible Pathway," Infection and Immunity, Sep. 1994, 62:3663-71. (Exhibit 23).
(9 pages)
[ISI abstract]
Gazzinelli, Ricardo T. et al., "Parasite-Induced IL-12 Stimulates Early IFN-γ Synthesis and Resistance During Acute Infection with Toxoplasma gondii," The Journal of Immunology, Sep. 15, 1994, 153:2533-43. (Exhibit 24).
(11 pages)
Cited by 2 patents
[ISI abstract]
Sieling, Peter A. et al., "IL-12 Regulates T Helper Type 1 Cytokine Responses in Human Infectious Disease," The Journal of Immunology, Oct. 1994, 153:3639-47. (Exhibit 25).
(9 pages)
Cited by 2 patents
[ISI abstract]
Cooper, A. M. et al., "The Role of Interleukin-12 in Acquired Immunity to Mycobacterium tuberculosis Infection," Immunology, Mar. 1995, 84:423-32. (Exhibit 26).
(10 pages)
[ISI abstract]
Radolf, Justin D. et al., "Treponema pallidum and Borrelia burgdorferi Lipoproteins and Synthetic Lipopeptides Activate Monocytes/Macrophages," The Journal of Immunology, Mar. 15, 1995, 154:2866-77. (Exhibit 27).
(12 pages)
Cited by 2 patents
[ISI abstract]
Flynn, JoAnne L. et al., "IL-12 Increases Resistance of BALB/c Mice to Mycobacterium tuberculosis Infection," The Journal of Immunology, Sep. 1, 1995, 155:5215-24. (Exhibit 28).
Wilkinson, Victoria L. et al., "Characterization of Anti-mouse IL-12 Monoclonal Antibodies and Measurement of Mouse IL-12 by ELISA," Journal of Immunological Methods, 1996, 189:15-24. (Exhibit 29).
(10 pages)
[ISI abstract]
Berman, Jeffrey S. et al., "Chemotactic Activity of Mycobacterial Lipoarabinomannans for Human Blood T Lymphocytes In Vitro," The Journal of Immunlogy, May 15, 1996, 156:3828-35. (Exhibit 30).
(8 pages)
[ISI abstract]
Kumar et al., 1990, Proc. Acad. Sci. USA, 87:1337-1341.*
(5 pages)
Cited by 81 patents
Finkelman et al., 1994, J. Exp. Med., 179:1563-1572.*
(10 pages)
[ISI abstract]
Germann et al., 1995, Immunology, 7:1649-1657.*
(9 pages)
Cited by 2 patents
[ISI abstract]
Jeannin et al. J. Immunol. 156:3159-3165, 1996.
(7 pages)
[ISI abstract]
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