Methods for modulating the activation of a lymphocyte expressed G protein coupled receptor involved in cell proliferation, autoimmunity and inflammation (US6709830)

Application Number	Filed	Pub. Date	Title
US2000000553875	2000-04-20	2003-02-04	Transcriptionally regulated G protein-coupled receptor G2A
US1998000120025	1998-07-17	2001-04-10	Transcriptionally regualted G protein-coupled receptor
US1997000969815	1997-11-13	2001-03-27	Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells


	Parent Case:			RELATED APPLICATIONS This present application is a continuation-in-part of U.S. patent application Ser. No. 09/553,875 filed Apr. 20, 2000, U.S. Pat. No. 6,514,696, which is a continuation-in-part of U.S. patent application Ser. No. 09/120,025 filed Jul. 17, 1998, U.S. Pat. No. 6,214,562, which is a continuation-in-part of U.S. patent application Ser. No. 08/969,815, filed on Nov. 13, 1997, U.S. Pat. No. 6,207,412.
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	First Claim: Show all 15 claims			What is claimed is: # SEQUENCE LISTING<160> NUMBER OF SEQ ID NOS: 11<210> SEQ ID NO 1<211> LENGTH: 1507<212> TYPE: DNA<213> ORGANISM: Mus musculis<220> FEATURE:<221> NAME/KEY: CDS<222> LOCATION: (147)...(1292)<400> SEQUENCE: 1aaacctccca gctgggcctg cagaggggtg ctcagccctg cctcaggacg g#gcctgccct 60gtgctgcctc aggactggct tgggtcattt taagctgcca gagccacctt c#acaaggggg 120tccacagaac tcacatagga gccacc atg aga tca gaa cct#acc aat gca gca 173# Met Arg Ser Glu#Pro Thr Asn Ala Ala# 1# 5gga aac acc aca ctg ggg gtt acc tcc gtt c#tt cag agc acc tca gta 221Gly Asn Thr Thr Leu Gly Val Thr Ser Val L#eu Gln Ser Thr Ser Val 10# 15# 20# 25cct tct tct gag acc tgc cac gtc tcc tac g#ag gag agc aga gtg gtc 269Pro Ser Ser Glu Thr Cys His Val Ser Tyr G#lu Glu Ser Arg Val Val 30# 35# 40ctg gtg gtg gtg tac agt gcc gtg tgc ctg c#tg ggc cta cca gcc aac 317Leu Val Val Val Tyr Ser Ala Val Cys Leu L#eu Gly Leu Pro Ala Asn 45# 50# 55tgc ctg act gcc tgg ctg acg ctg ctg caa g#tc ctg cag agg aac gtg 365Cys Leu Thr Ala Trp Leu Thr Leu Leu Gln V#al Leu Gln Arg Asn Val 60# 65# 70cta gcc gtc tac ctg ttc tgc ctg tcc ctc t#gt gag ctg ctc tac atc 413Leu Ala Val Tyr Leu Phe Cys Leu Ser Leu C#ys Glu Leu Leu Tyr Ile 75# 80# 85agc acg gtg cca ttg tgg atc atc tac atc c#ag aat cag cac aaa tgg 461Ser Thr Val Pro Leu Trp Ile Ile Tyr Ile G#ln Asn Gln His Lys Trp 90# 95#100#105aac ctg ggt ccg cag gcc tgc aag gtg act g#ct tac atc ttc ttc tgc 509Asn Leu Gly Pro Gln Ala Cys Lys Val Thr A#la Tyr Ile Phe Phe Cys 110# 115# 120aac atc tac atc agc atc ctc ttg ctc tgc t#gc att tcc tgc gac cgc 557Asn Ile Tyr Ile Ser Ile Leu Leu Leu Cys C#ys Ile Ser Cys Asp Arg 125# 130# 135tac atg gcc gtg gtc tat gca ctg gag agc c#ga ggc cac cgc cac cag 605Tyr Met Ala Val Val Tyr Ala Leu Glu Ser A#rg Gly His Arg His Gln 140# 145# 150agg act gct gtc acc att tct gcg tgt gtg a#tt ctt ctt gtt gga ctt 653Arg Thr Ala Val Thr Ile Ser Ala Cys Val I#le Leu Leu Val Gly Leu 155# 160# 165gtt aac tat cca gtg ttt gac atg aag gtg g#ag aag agt ttc tgc ttt 701Val Asn Tyr Pro Val Phe Asp Met Lys Val G#lu Lys Ser Phe Cys Phe170#175#180#185gag ccc ctg agg atg aac agc aag ata gcc g#gc tac cac tac ctg cgt 749Glu Pro Leu Arg Met Asn Ser Lys Ile Ala G#ly Tyr His Tyr Leu Arg 190# 195# 200ttc acc ttt ggc ttt gcc atc cct ctc ggc a#tc ctg gcg ttc acc aat 797Phe Thr Phe Gly Phe Ala Ile Pro Leu Gly I#le Leu Ala Phe Thr Asn 205# 210# 215cac cag atc ttc cgg agc atc aaa ctc agt g#ac agc ctg agc gct gcg 845His Gln Ile Phe Arg Ser Ile Lys Leu Ser A#sp Ser Leu Ser Ala Ala 220# 225# 230cag aag aac aag gtg aag cgc tcc gcc atc g#cg gtc gtc acc atc ttc 893Gln Lys Asn Lys Val Lys Arg Ser Ala Ile A#la Val Val Thr Ile Phe 235# 240# 245ctg gtc tgc ttt gct ccc tac cac gtg gta c#tc ctc gtc aaa gct gcc 941Leu Val Cys Phe Ala Pro Tyr His Val Val L#eu Leu Val Lys Ala Ala250#255#260#265agc ttt tcc ttc tac caa gga gac atg gat g#cc gtg tgt gcc ttt gaa 989Ser Phe Ser Phe Tyr Gln Gly Asp Met Asp A#la Val Cys Ala Phe Glu 270# 275# 280agc aga ctg tac aca gtc tct atg gtg ttt c#tg tgc ctg tct aca gtc 1037Ser Arg Leu Tyr Thr Val Ser Met Val Phe L#eu Cys Leu Ser Thr Val 285# 290# 295aac agt gtg gct gac ccc atc atc tac gtg c#tg ggt aca gac cac tct 1085Asn Ser Val Ala Asp Pro Ile Ile Tyr Val L#eu Gly Thr Asp His Ser 300# 305# 310cgg caa gaa gtg tcc aga atc cac aca ggg t#gg aaa aag tgg tcc aca 1133Arg Gln Glu Val Ser Arg Ile His Thr Gly T#rp Lys Lys Trp Ser Thr 315# 320# 325aag aca tat gtt aca tgc tca aag gac tct g#ag gag aca cac ttg ccc 1181Lys Thr Tyr Val Thr Cys Ser Lys Asp Ser G#lu Glu Thr His Leu Pro330#335#340#345aca gag ctt tca aac aca tac acc ttc ccc a#at ccc gcg cac cct cca 1229Thr Glu Leu Ser Asn Thr Tyr Thr Phe Pro A#sn Pro Ala His Pro Pro 350# 355# 360gga tca cag cca gcg aag cta ggt tta ctg t#gc tcg cca gag aga ctg 1277Gly Ser Gln Pro Ala Lys Leu Gly Leu Leu C#ys Ser Pro Glu Arg Leu 365# 370# 375cct gag gag ctc tgc taagagacga ttgtccactc ttcctcaa#aa ctagcaccag 1332Pro Glu Glu Leu Cys 380tcacacatac ctggtcctct gagtcaccgt ctggggtgtc cacagcacta t#agatgcctt 1392tgttcgggca cacgctgctg atctttcctt cctaaggcca ccaactctga a#agtatctgt 1452tccttaaact gtcctcaggc tcccctctat ggaaagcggg gcttgctaag g#gacc 1507<210> SEQ ID NO 2<211> LENGTH: 382<212> TYPE: PRT<213> ORGANISM: Mus musculis<400> SEQUENCE: 2Met Arg Ser Glu Pro Thr Asn Ala Ala Gly A#sn Thr Thr Leu Gly Val 1 5# 10# 15Thr Ser Val Leu Gln Ser Thr Ser Val Pro S#er Ser Glu Thr Cys His 20# 25# 30Val Ser Tyr Glu Glu Ser Arg Val Val Leu V#al Val Val Tyr Ser Ala 35# 40# 45Val Cys Leu Leu Gly Leu Pro Ala Asn Cys L#eu Thr Ala Trp Leu Thr 50# 55# 60Leu Leu Gln Val Leu Gln Arg Asn Val Leu A#la Val Tyr Leu Phe Cys65#70#75#80Leu Ser Leu Cys Glu Leu Leu Tyr Ile Ser T#hr Val Pro Leu Trp Ile 85# 90# 95Ile Tyr Ile Gln Asn Gln His Lys Trp Asn L#eu Gly Pro Gln Ala Cys 100# 105# 110Lys Val Thr Ala Tyr Ile Phe Phe Cys Asn I#le Tyr Ile Ser Ile Leu 115# 120# 125Leu Leu Cys Cys Ile Ser Cys Asp Arg Tyr M#et Ala Val Val Tyr Ala 130# 135# 140Leu Glu Ser Arg Gly His Arg His Gln Arg T#hr Ala Val Thr Ile Ser145#150#155#160Ala Cys Val Ile Leu Leu Val Gly Leu Val A#sn Tyr Pro Val Phe Asp 165# 170# 175Met Lys Val Glu Lys Ser Phe Cys Phe Glu P#ro Leu Arg Met Asn Ser 180# 185# 190Lys Ile Ala Gly Tyr His Tyr Leu Arg Phe T#hr Phe Gly Phe Ala Ile 195# 200# 205Pro Leu Gly Ile Leu Ala Phe Thr Asn His G#ln Ile Phe Arg Ser Ile 210# 215# 220Lys Leu Ser Asp Ser Leu Ser Ala Ala Gln L#ys Asn Lys Val Lys Arg225#230#235#240Ser Ala Ile Ala Val Val Thr Ile Phe Leu V#al Cys Phe Ala Pro Tyr 245# 250# 255His Val Val Leu Leu Val Lys Ala Ala Ser P#he Ser Phe Tyr Gln Gly 260# 265# 270Asp Met Asp Ala Val Cys Ala Phe Glu Ser A#rg Leu Tyr Thr Val Ser 275# 280# 285Met Val Phe Leu Cys Leu Ser Thr Val Asn S#er Val Ala Asp Pro Ile 290# 295# 300Ile Tyr Val Leu Gly Thr Asp His Ser Arg G#ln Glu Val Ser Arg Ile305#310#315#320His Thr Gly Trp Lys Lys Trp Ser Thr Lys T#hr Tyr Val Thr Cys Ser 325# 330# 335Lys Asp Ser Glu Glu Thr His Leu Pro Thr G#lu Leu Ser Asn Thr Tyr 340# 345# 350Thr Phe Pro Asn Pro Ala His Pro Pro Gly S#er Gln Pro Ala Lys Leu 355# 360# 365Gly Leu Leu Cys Ser Pro Glu Arg Leu Pro G#lu Glu Leu Cys 370# 375# 380<210> SEQ ID NO 3<211> LENGTH: 2938<212> TYPE: DNA<213> ORGANISM: Homo sapiens<220> FEATURE:<221> NAME/KEY: CDS<222> LOCATION: (901)...(2040)<223> OTHER INFORMATION: n = a, c, t,#or g<400> SEQUENCE: 3gggaggggtg cnangctagc cacgcaggcg gggccctggg tcattttaan c#tctcagagt 60gaacgtcttg ataggaccga caanacncat nacntgtact tagatagctt a#tcttananc 120cacnctgana ttggaacccg caaaatatgc cngggaggaa ggtgagcaag g#gacacgaca 180ctcacccgga taaacccaac aagcgcagcg aggctgtggg gaaaccggan c#cctgcacac 240cgccggggga aggtgggccn ccgccaccac cgtggaagaa cagcgcggan g#caccccacg 300agatgagacg gaactgccgt gagatccagc aatnccnact gtgggtctga c#ccaggatan 360cggaaagcag ggacgtgaac agccctcctc atgttcttga caccgtcatt c#tcagcagct 420cagctaaggc acagaggcag ccgagcgtct gtcagcagag tcgtggctga g#cagaacacg 480ccacacgcca cacgccacac gccacacgtg caggattgct caagatggaa g#ggcacagtg 540gaatatatat atatatttat atttttggcg agaccctgga ggacacactg a#atacaatgg 600aataccatcc cgcctttgaa aggaagggaa atcctggcac acgctgcaac a#ggagggagc 660ttgaggacac tgtggtgagt ggagcacgtg agacacggaa ggacacacgc t#gaagacacg 720cagagatgcc cacccacgtg gggaggtgac aggggagccc agcgcacaga g#acaaagtgg 780aatggaggcc tgggggctgg gagcaaatgc ggagcgagtg cttcctgggg c#agagtctcc 840gtttgggaag atgagaaggt tctgccgacg gatgctggcg atggttgcag a#agaatgtga 900atg tgc cca atg cta ctg aaa aac ggt tac a#at gga aac gcc acc cca 948Met Cys Pro Met Leu Leu Lys Asn Gly Tyr A#sn Gly Asn Ala Thr Pro 1 5# 10# 15gtg acc acc act gcc ccg tgg gcc tcc ctg g#gc ctc tcc gcc aag acc 996Val Thr Thr Thr Ala Pro Trp Ala Ser Leu G#ly Leu Ser Ala Lys Thr 20# 25# 30tgc aac aac gtg tcc ttc gaa gag agc agg a#ta gtc ctg gtc gtg gtg 1044Cys Asn Asn Val Ser Phe Glu Glu Ser Arg I#le Val Leu Val Val Val 35# 40# 45tac agc gcg gtg tgc acg ctg ggg gtg ccg g#cc aac tgc ctg act gcg 1092Tyr Ser Ala Val Cys Thr Leu Gly Val Pro A#la Asn Cys Leu Thr Ala 50# 55# 60tgg ctg gcg ctg ctg cag gta ctg cag ggc a#ac gtg ctg gcc gtc tac 1140Trp Leu Ala Leu Leu Gln Val Leu Gln Gly A#sn Val Leu Ala Val Tyr 65# 70# 75# 80ctg ctc tgc ctg gca ctc tgc gag ctg ctg t#ac aca ggc acg ctg cca 1188Leu Leu Cys Leu Ala Leu Cys Glu Leu Leu T#yr Thr Gly Thr Leu Pro 85# 90# 95ctc tgg gtc atc tat atc cgc aac cag cac c#gc tgg acc cta ggc ctg 1236Leu Trp Val Ile Tyr Ile Arg Asn Gln His A#rg Trp Thr Leu Gly Leu 100# 105# 110ctg gcc tgc aag gtg acc gcc tac atc ttc t#tc tgc aac atc tac gtc 1284Leu Ala Cys Lys Val Thr Ala Tyr Ile Phe P#he Cys Asn Ile Tyr Val 115# 120# 125agc atc ctc ttc ctg tgc tgc atc tcc tgc g#ac cgc ttc gtg gcc gtg 1332Ser Ile Leu Phe Leu Cys Cys Ile Ser Cys A#sp Arg Phe Val Ala Val 130# 135# 140gtg tac gcg ctg gag agt cgg ggc cgc cgc c#gc cgg agg acc gcc atc 1380Val Tyr Ala Leu Glu Ser Arg Gly Arg Arg A#rg Arg Arg Thr Ala Ile145#150#155#160ctc atc tcc gcc tgc atc ttc atc ctc gtc g#gg atc gtt cac tac ccg 1428Leu Ile Ser Ala Cys Ile Phe Ile Leu Val G#ly Ile Val His Tyr Pro 165# 170# 175gtg ttc cag acg gaa gac aag gag acc tgc t#tt gac atg ctg cag atg 1476Val Phe Gln Thr Glu Asp Lys Glu Thr Cys P#he Asp Met Leu Gln Met 180# 185# 190gac agc agg att gcc ggg tac tac tac gcc a#gg ttc acc gtt ggc ttt 1524Asp Ser Arg Ile Ala Gly Tyr Tyr Tyr Ala A#rg Phe Thr Val Gly Phe 195# 200# 205gcc atc cct ctc tcc atc atc gcc ttc acc a#ac cac cgg att ttc agg 1572Ala Ile Pro Leu Ser Ile Ile Ala Phe Thr A#sn His Arg Ile Phe Arg 210# 215# 220agc atc aag cag agc atg ggc tta agc gct g#cc cag aag gcc aag gtg 1620Ser Ile Lys Gln Ser Met Gly Leu Ser Ala A#la Gln Lys Ala Lys Val225#230#235#240aag cac tcg gcc atc gcg gtg gtt gtc atc t#tc cta gtc tgc ttc gcc 1668Lys His Ser Ala Ile Ala Val Val Val Ile P#he Leu Val Cys Phe Ala 245# 250# 255ccg tac cac ctg gtt ctc ctc gtc aaa gcc g#ct gcc ttt tcc tac tac 1716Pro Tyr His Leu Val Leu Leu Val Lys Ala A#la Ala Phe Ser Tyr Tyr 260# 265# 270aga gga gac agg aac gcc atg tgc ggc ttg g#ag gaa agg ctg tac aca 1764Arg Gly Asp Arg Asn Ala Met Cys Gly Leu G#lu Glu Arg Leu Tyr Thr 275# 280# 285gcc tct gtg gtg ttt ctg tgc ctg tcc acg g#tg aac ggc gtg gct gac 1812Ala Ser Val Val Phe Leu Cys Leu Ser Thr V#al Asn Gly Val Ala Asp 290# 295# 300ccc att atc tac gtg ctg gcc acg gac cat t#cc cgc caa gaa gtg tcc 1860Pro Ile Ile Tyr Val Leu Ala Thr Asp His S#er Arg Gln Glu Val Ser305#310#315#320aga atc cat aag ggg tgg aaa gag tgg tcc a#tg aag aca gac gtc acc 1908Arg Ile His Lys Gly Trp Lys Glu Trp Ser M#et Lys Thr Asp Val Thr 325# 330# 335agg ctc acc cac agc agg gac acc gag gag c#tg cag tcg ccc gtg gcc 1956Arg Leu Thr His Ser Arg Asp Thr Glu Glu L#eu Gln Ser Pro Val Ala 340# 345# 350ctt gca gac cac tac acc ttc tcc agg ccc g#tg cac cca cca ggg tca 2004Leu Ala Asp His Tyr Thr Phe Ser Arg Pro V#al His Pro Pro Gly Ser 355# 360# 365cca tgc cct gca aag agg ctg att gag gag t#cc tgc tgagcccact 2050Pro Cys Pro Ala Lys Arg Leu Ile Glu Glu S#er Cys 370# 375# 380gtgtggcagg gggatggcag gttgggggtc ctggggccag caatgtggtt c#ctgtgcact 2110gagcccacca gccacagtgc ccatgtcccc tctggaagac aaactaccaa t#ttctcgttc 2170ctgaagccac tccctccgtg accactggcc ccangctttc ccacatggaa g#gtggctgca 2230tgccaagggg aagaacgaca cctccaggct tccgggagcc cananancat g#tggcangca 2290gtggggcctc ttcatcatca ncctgcctgg ctggctccct tggctgtggg c#angtacacc 2350cctgctggca naagtacctg gtggctgccc tgttcgcatc antggcgatn a#ctttatttg 2410cggagcattt ctgcaancgt tgcctggatn cggtggtgca ttgtgggccc t#ctgggctcc 2470tgcctcaaaa tgtcagtgan caccatgctg gaagtcacca tcactgtggc a#ncgcccang 2530aaggcatang gcacctacca cctccaangg ggcangcgcc ctcatctggg g#ttgggtctn 2590ttgctgaact gggaaggcct ctangggaac cctggggcan ggtggccaac t#gctngctcc 2650canaaaccaa cccaaggcgt ctcaacgggg gaaccccaaa tgttcncgcc c#canaaaaaa 2710caattttngg aagganaagt tnttaaacac cccnccncca naagccaagg g#gttcccagg 2770aaattcccca ccggcatcct ccggggaaaa nactcggtna angggtccct t#acaagggtt 2830gggggttccc cncccctaac ccccnttaat tgaagggggg gaaattcaac c#cttttggcc 2890tccttttttt ttgcggnaaa aaaaacaacn tcccctgcan cccccggn# 2938<210> SEQ ID NO 4<211> LENGTH: 380<212> TYPE: PRT<213> ORGANISM: Homo sapiens<400> SEQUENCE: 4Met Cys Pro Met Leu Leu Lys Asn Gly Tyr A#sn Gly Asn Ala Thr Pro 1 5# 10# 15Val Thr Thr Thr Ala Pro Trp Ala Ser Leu G#ly Leu Ser Ala Lys Thr 20# 25# 30Cys Asn Asn Val Ser Phe Glu Glu Ser Arg I#le Val Leu Val Val Val 35# 40# 45Tyr Ser Ala Val Cys Thr Leu Gly Val Pro A#la Asn Cys Leu Thr Ala 50# 55# 60Trp Leu Ala Leu Leu Gln Val Leu Gln Gly A#sn Val Leu Ala Val Tyr65#70#75#80Leu Leu Cys Leu Ala Leu Cys Glu Leu Leu T#yr Thr Gly Thr Leu Pro 85# 90# 95Leu Trp Val Ile Tyr Ile Arg Asn Gln His A#rg Trp Thr Leu Gly Leu 100# 105# 110Leu Ala Cys Lys Val Thr Ala Tyr Ile Phe P#he Cys Asn Ile Tyr Val 115# 120# 125Ser Ile Leu Phe Leu Cys Cys Ile Ser Cys A#sp Arg Phe Val Ala Val 130# 135# 140Val Tyr Ala Leu Glu Ser Arg Gly Arg Arg A#rg Arg Arg Thr Ala Ile145#150#155#160Leu Ile Ser Ala Cys Ile Phe Ile Leu Val G#ly Ile Val His Tyr Pro 165# 170# 175Val Phe Gln Thr Glu Asp Lys Glu Thr Cys P#he Asp Met Leu Gln Met 180# 185# 190Asp Ser Arg Ile Ala Gly Tyr Tyr Tyr Ala A#rg Phe Thr Val Gly Phe 195# 200# 205Ala Ile Pro Leu Ser Ile Ile Ala Phe Thr A#sn His Arg Ile Phe Arg 210# 215# 220Ser Ile Lys Gln Ser Met Gly Leu Ser Ala A#la Gln Lys Ala Lys Val225#230#235#240Lys His Ser Ala Ile Ala Val Val Val Ile P#he Leu Val Cys Phe Ala 245# 250# 255Pro Tyr His Leu Val Leu Leu Val Lys Ala A#la Ala Phe Ser Tyr Tyr 260# 265# 270Arg Gly Asp Arg Asn Ala Met Cys Gly Leu G#lu Glu Arg Leu Tyr Thr 275# 280# 285Ala Ser Val Val Phe Leu Cys Leu Ser Thr V#al Asn Gly Val Ala Asp 290# 295# 300Pro Ile Ile Tyr Val Leu Ala Thr Asp His S#er Arg Gln Glu Val Ser305#310#315#320Arg Ile His Lys Gly Trp Lys Glu Trp Ser M#et Lys Thr Asp Val Thr 325# 330# 335Arg Leu Thr His Ser Arg Asp Thr Glu Glu L#eu Gln Ser Pro Val Ala 340# 345# 350Leu Ala Asp His Tyr Thr Phe Ser Arg Pro V#al His Pro Pro Gly Ser 355# 360# 365Pro Cys Pro Ala Lys Arg Leu Ile Glu Glu S#er Cys 370# 375# 380<210> SEQ ID NO 5<211> LENGTH: 13<212> TYPE: PRT<213> ORGANISM: Mus musculis<400> SEQUENCE: 5Lys Asp Ser Glu Glu Thr His Leu Pro Thr G#lu Leu Ser 1 5# 10<210> SEQ ID NO 6<211> LENGTH: 21<212> TYPE: DNA<213> ORGANISM: Mus musculis<400> SEQUENCE: 6tagcggtcgc aggaaatgca g###21<210> SEQ ID NO 7<211> LENGTH: 20<212> TYPE: DNA<213> ORGANISM: Mus musculis<400> SEQUENCE: 7caggactggc ttgggtcatt### 20<210> SEQ ID NO 8<211> LENGTH: 20<212> TYPE: DNA<213> ORGANISM: Artificial Sequence<220> FEATURE:<223> OTHER INFORMATION: Primer<400> SEQUENCE: 8gcacctgtgg ggaagaaact### 20<210> SEQ ID NO 9<211> LENGTH: 24<212> TYPE: DNA<213> ORGANISM: Artificial Sequence<220> FEATURE:<223> OTHER INFORMATION: Primer<400> SEQUENCE: 9tgagagctgt ctcctactat cgat## 24<210> SEQ ID NO 10<211> LENGTH: 31<212> TYPE: DNA<213> ORGANISM: Artificial Sequence<220> FEATURE:<223> OTHER INFORMATION: Primer<400> SEQUENCE: 10agggatcctt gtgaagggat ctactactgt g## 31<210> SEQ ID NO 11<211> LENGTH: 26<212> TYPE: DNA<213> ORGANISM: Artificial Sequence<220> FEATURE:<223> OTHER INFORMATION: Primer<400> SEQUENCE: 11aaagacctgc agaggccatt cttacc## 26 1. A method of modulating G2A receptor (FIG. 2, SEQ ID NOS: 2 and 4) mediated signaling in a cell comprising increasing or decreasing the concentration of G2A ligand present in the cell's environment that is capable of binding and activating the G2A receptor.
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Foreign References:

Buy PDF	Publication	Date	IPC Code	Assignee	Title
	WO9925830	1999-05	C12N 15/12	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	TRANSCRIPTIONALLY REGULATED G PROTEIN-COUPLED RECEPTOR

Other Abstract Info:

DERABS C2002-443694

Other References:

Mahadevan, M. S. et al., Isolation of a novel G protein coupled receptor, PIR 76 Database, Accession No. B57641, Feb. 8, 1996.*

Mahadevan, M. S. et al., Isolation of a novel G protein coupled receptor, Swissprot 41 Database, Accession No.P50132, Nov. 1, 1996.*

J.H.S. Kabarowski et al., 2000, "Direct genetic demonstration of . . . rearrangement," PNAS, 97(22):12109-12114, 2000. (6 pages) Cited by 3 patents [ISI abstract]

I.F. Zohn et al., 2000, "G2A is an oncogenic G protein-coupled receptor," Oncogene (2000) 19:3866-3877, 2000. (12 pages) Cited by 3 patents [ISI abstract]

W.H. Moolenaar, 1999, "Bioactive Lysophospholipids and Their G Protein-Coupled Receptors," Experimental Cell Research 253:230-238, 1999. (9 pages) Cited by 3 patents [ISI abstract]

Choe et al., "The β-Chemokine . . . Isolates," Cell, 85:1135-1148, 1996. (14 pages) Cited by 55 patents [ISI abstract]

R.J. Davis, "Transcriptional Regulation by MAP Kinases," Molecular Reproduction and Development, 42:459-467, 1995. (9 pages) Cited by 5 patents [ISI abstract]

Deng et al., "Identification of a major co-receptor for primary isolates of HIV-1" Nature, 381:661-666, 1996. (6 pages) Cited by 107 patents [ISI abstract]

Choi et al., "Identification of a Putative G Protein . . . Cells," Cellular Immunology, 168:78-84, 1996. (7 pages) Cited by 5 patents [ISI abstract]

Doranz et al., "A Dual-Tropic Primary . . . Cofactors," Cell, 85:1148-1158, 1996.

Dragic et al., "HIV-1 entry into CD4⁺ cells . . . CC-CKR-5," Nature, 381:667-673, 1996. (7 pages) Cited by 96 patents [ISI abstract]

Feng et al., "HIV-1 Entry Cofactor: Functional cDNA . . . Receptor," Science, 272:872-877, 1996. (6 pages) Cited by 96 patents [ISI abstract]

Forster et al., "A Putative Chemokine Receptor . . . Spleen," Cell, 87:1037-1047, 1996. (11 pages) Cited by 6 patents [ISI abstract]

M.L.X. Fu, "Characterization of anti-heart M2 muscarinic . . . study," Molccular and Cellular Biochemistry, 163/164:343-347, 1996. (5 pages) Cited by 5 patents [ISI abstract]

Goga et al., "Alternative Signals to RAS for Hematopoietic . . . Oncogene," Cell, 82:981-988, 1995. (8 pages) Cited by 5 patents [ISI abstract]

Hubank et al., "Identifying differences in mRNA expression . . . cDNA," Nucleic Acids Research, 22(25):5640-5648, 1996.

Koshiba et al., "Transient up-regulation of P2Y₂ nucleotide . . . thymocytes," Proc. Natl. Acad. Sci. USA, 94:831-836, 1997. (6 pages) Cited by 5 patents [ISI abstract]

Kurzrock et al., "The Molecular Genetics of . . . Leukemias," The New England Journal of Medicine, 319(15):990-998, 1988. (9 pages) Cited by 7 patents

Lugo et al., "The BCR0ABL Oncogene . . . v-myc," Molecular and Cellular Biology 9(3):1263-1270, 1989. (8 pages) Cited by 8 patents

McLaughlin et al., "Alternative Forms of the . . . Cells," Molecular and Cellular Biology, 9(5):1866-1874, 1989. (9 pages) Cited by 10 patents

Muller et al., "BCR First Exon Sequences . . . Leukemias," Molecular and Cellular Biology, 11(4):1785-1792, 1991. (8 pages) Cited by 31 patents [ISI abstract]

P.M. Murphy, "The Molecular Biology . . . Receptors," Annu. Rev. Immunol., 12:593-633, 1994. (41 pages) Cited by 74 patents [ISI abstract]

Pear et al., "Production of high-titer helper-free . . . transfection," Proc. Natl. Acad. Sci. USA 90:8392-8396, 1993. (5 pages) Cited by 77 patents [ISI abstract]

Pendergast et al., "BCR-ABL-Induced Oncogenesis . . . Protein," Cell, 75:175-185, 1997.

Schneider et al., "Genes Specifically Expressed . . . Cells," Cell, 54:787-793, 1988. (7 pages) Cited by 17 patents

Strader et al., "The family of G-protein-coupled receptors," The FASEB Journal, 9:745-754, 1995. (10 pages) Cited by 18 patents [ISI abstract]

Strader et al., "Structure and Function of G Protein-Coupled Receptors," Annu. Rev. Biochem., 63:101-132, 1996.

Tsukada et al., "Deficient Expression of a . . . Agammaglobulinemia," Cell 72:279-290, 1993. (12 pages) Cited by 11 patents [ISI abstract]

Lisitsyn et al., "Cloning the Differences Between . . . Genomes," Science 259:946-951, 1997.

Libert et al., "Selective Amplitication and Cloning . . . Family," Science, 244:569-572, 1989. (4 pages) Cited by 86 patents

Bouvier et al., "Dynamic Palmitoylation of G-Protein . . . Cells," Methods in Enzymology, Academic Press, pp. 300-314, 1995. (15 pages) Cited by 11 patents [ISI abstract]

Continuity Data:

Application Number

Filed

Notes

>US2001000796266<

2001-02-28

is a continuation in part of

US2000000553875

2000-04-20

(pending) [presumed granted]

US6514696 issued 2003-02-04 Transcriptionally regulated G protein-coupled receptor G2A

US2000000553875

2000-04-20

is a continuation in part of

US1998000120025

1998-07-17

(granted)

US6214562 issued 2001-04-10 Transcriptionally regualted G protein-coupled receptor

US1998000120025

1998-07-17

is a continuation in part of

US1997000969815

1997-11-13

(granted)

US6207412 issued 2001-03-27 Identification of a G protein-coupled receptor transcriptionally regulated by protein tyrosine kinase signaling in hematopoietic cells

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