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Title: US7204982: Compositions and methods for treatment and detection of multiple cancers
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Country: US United States of America

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34 pages

 
Inventor: Liau, Linda M.; Los Angeles, CA, United States of America

Assignee: The Regents of the University of California, Oakland, CA, United States of America
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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Published / Filed: 2007-04-17 / 2002-07-02

Application Number: US2002000188840

IPC Code: Advanced: A61K 39/395; C07H 21/04; C07K 14/47; C07K 16/30; G01N 33/574; A61K 39/00;
Core: C07H 21/00; C07K 14/435; C07K 16/18; more...

ECLA Code: C07H21/04; C07K14/47A1A; C07K16/30; G01N33/574V;

U.S. Class: Current: 424/130.1; 424/155.1; 424/185.1; 514/044.A; 536/023.1; 536/024.3;
Original: 424/130.1; 424/155.1; 424/185.1; 514/044; 536/023.1; 536/024.3;

Field of Search: 514/002,21,44 530/388.85,387.1 435/69.1,9.1,6 424/187.1,130.1,155.1,185.1 536/23.1,24.3

Priority Number:
2002-07-02  US2002000188840

Abstract:     The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate and colon. The method comprises contacting a cancer cell with a molecule that disrupts the biological activity of a GDOX molecule. In one embodiment, the molecule is an antibody directed against a GDOX peptide. In other embodiments, the molecule is an antisense nucleotide directed against a GDOX nucleic acid molecule, or a vaccine comprising a GDOX peptide or a polynucleotide encoding a GDOX peptide. The invention additionally provides methods for detecting and treating cancer using GDOX-related molecules.

Attorney, Agent or Firm: Canady + Lortz LLP ; Canady, Karen S. ;

Primary / Asst. Examiners: Siew, Jeffrey; Davis, Minh-Tam

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First Claim:
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    1. A method for inhibiting proliferation of glioblastoma cells in vitro comprising contacting a glioblastoma cell with a molecule selected from the group consisting of a GDOX antibody that specifically binds to the amino acid sequence of SEQ ID NO: 2, and the nucleic acid sequence comprising the full length antisense of SEQ ID NO: 1.

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U.S. References: Go to Result Set: All U.S. references   |  No patents reference this one   |   Backward references (3)   |   Citation Link

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Patent  Pub.Date  Inventor Assignee   Title
Buy PDF- 35pp US5840708  1998-11 Weiss  Allegheny University of the Health Sciences Administration of oligonucleotides antisense to dopamine receptor MRNA for diagnosis and treatment of Neurological pathologies
Buy PDF- 30pp US5912143  1999-06 Bandman et al.  Incyte Pharmaceuticals, Inc. Polynucleotides encoding a human mage protein homolog
Buy PDF- 21pp US20020147147A1  2002-10 Molling et al.   NUCLEIC ACID MOLECULES ENCODING A PROTEIN INTERACTING WITH THE CHEMOKINE RECEPTOR CCR5 OR OTHER CHEMOKINE RECEPTOR FAMILY MEMBERS
       
Foreign References:
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Publication Date IPC Code Assignee   Title
Buy PDF- 2537pp EP1074617A2 2001-02  C07K 14/435 Helix Research Institute Primers for synthesising full-length cDNA and their use 
Buy PDF- 509pp WO0222660A2 2002-03  A61K 38/00 ASUNDI VINOD NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 
Buy PDF- 509pp WO0222660A2 2002-03  A61K 38/00 ASUNDI VINOD NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 


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  • Continuity Data:
    Application Number Filed Notes

    US2002000188840 2002-07-02  is a related to the prior publication
         US20040005642A1 issued 2004-01-08  Compositions and methods for treatment and detection of multiple cancers


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