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 Title: |
US20020128441A1:
Endoderm, cardiac and neural inducing factors - murine frazzled (FRZB-1) protein
[ Derwent Title ]
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| Country: |
US United States of America
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| Inventor: |
De Robertis, Edward M.; Pacific Palisades, CA, United States of America
Bouwmeester, Tewis; Heidelberg, Germany
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| Assignee: |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
other patents from UNIVERSITY OF CALIFORNIA, THE REGENTS OF (599425) (approx. 4,840)
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| Published / Filed: |
2002-09-12
/ 2001-07-11
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| Application Number: |
US2001000903325
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| IPC Code: |
Advanced:
C07K 14/475;
A61K 38/00;
Core:
C07K 14/435;
more...
IPC-7:
A61K 38/17;
C07H 21/04;
C07K 14/435;
C12N 5/06;
C12P 21/02;
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| ECLA Code: |
C07K14/475;
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| U.S. Class: |
Current:
530/350;
435/320.1;
435/325;
536/023.5;
Original:
530/350;
536/023.5;
435/325;
435/320.1;
514/012;
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| Government Interest: |
This invention was made with Government support under grant contract number HD-21502, awarded by the National Institutes of Health. The Government has certain rights in this invention.
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| Priority Number: |
| 2001-07-11 |
US2001000903325 |
| 2000-04-21 |
US2000000552988 |
| 1996-06-20 |
US1996000020150P |
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| Abstract: |
Novel proteins have been designated “cerberus” and “frzb-1,” respectively. Cerebus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is therm PAPC which promotes the formation of dorsal mesoderm and somites in the embryo.
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| Attorney, Agent or Firm: |
Attention: Charles Berman OPPENHEIMER WOLFF & DONNELLY; 38th Floor2029 Century Park East
, Los Angeles
, CA
90067-3024 United States of America
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| INPADOC Legal Status: |
None
Family Legal Status Report
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| Parent Case: |
This application claims the benefit of U.S. Provisional application Ser. No. 60/020,150, filed Jun. 20, 1996.
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| Designated Country: |
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE AU CA EP JP
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| Family: |
Show 18 known family members
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First Claim:
Show all claims |
It is claimed:
1. A substantially pure protein characterized by a physiologically active form and comprising an amino acid sequence encoded by the DNA of SEQ ID NO:2.
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| Background / Summary: |
Show background / summary
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| Drawing Descriptions: |
Show drawing descriptions
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| Description: |
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